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Ribonucleotide reductase M2

RRM2, R-2, RR2, ribonucleotide reductase M2
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, Hoxa5, HAD, ACID, V1a
Papers on RRM2
Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein.
Shao et al., Hangzhou, China. In Biochem Pharmacol, Feb 2016
By performing computer-assisted virtual screening against the crystal structure of RR small subunit M2 (RRM2), osalmid, was identified as a potential RRM2-targeting compound.
Cuticular protein and transcription factor genes expressed during prepupal-pupal transition and by ecdysone pulse treatment in wing discs of Bombyx mori.
Kawasaki et al., Utsunomiya, Japan. In Insect Mol Biol, Feb 2016
Fifty-two CP genes (RR-1 13, RR-2 18, CPG 8, CPT 3, CPFL 2, CPH 8) in wing discs of B. mori were examined.
RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression.
Sun et al., Qingdao, China. In Exp Mol Pathol, Jan 2016
Hub nodes in the PPI network were RRM2 and a set of collagens (COL1A1, COL3A1 and COL5A1), which were also remarkable in module 3 and module 5, respectively.
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Humphrey et al., Oxford, United Kingdom. In Cancer Cell, Nov 2015
We show that RRM2, a ribonucleotide reductase subunit, is the target of this synthetic lethal interaction.
Identification of potential glucocorticoid receptor therapeutic targets in multiple myeloma.
Rosen et al., Houston, United States. In Nucl Recept Signal, 2014
As a proof of principle, we have verified two targets, namely RRM2 and BCL2L1, as primary functional targets of GR involved in GC-induced cell death.
Investigation of some DNA repair genes association in non small cell lung cancer.
Yaylim et al., İstanbul, Turkey. In Cell Mol Biol (noisy-le-grand), 2014
Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene and also Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.
Inferior vena cava filters and postoperative outcomes in patients undergoing bariatric surgery: a meta-analysis.
Cardiovascular Meta-analysis Research Group et al., Lima, Peru. In Surg Obes Relat Dis, 2014
Use of IVC filters was associated with an approximately 3-fold higher risk of DVT and death that was nominally significant for the former outcome, but not the latter (RR2.81,95%CI
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
Pagano et al., New York City, United States. In Cell, 2012
After DNA damage, cyclin F is downregulated in an ATR-dependent manner to allow accumulation of RRM2. Defective elimination of cyclin F delays DNA repair and sensitizes cells to DNA damage, a phenotype that is reverted by expressing a nondegradable RRM2 mutant.
Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.
Yang et al., Shantou, China. In J Biol Chem, 2012
Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
Nakajima et al., Japan. In Viruses, 2012
Megalocytiviruses contain only the RR-2 gene, which is of eukaryotic origin; whereas the other genera encode both the RR-1 and RR-2 genes which are thought to originate from Rickettsia-like α-proteobacteria.
Regulation of urokinase expression at the posttranscription level by lung epithelial cells.
Shetty et al., Tyler, United States. In Biochemistry, 2012
Recombinant RRM2 translocates from the cytoplasm to the nucleus in a time-dependent manner, leading to stabilization of urokinase mRNA. Overexpression of RRM2 inhibits urokinase protein and mRNA expression through destabilization of uPA mRNA.
Ribonucleotide reductase M2 does not predict survival in patients with resectable pancreatic adenocarcinoma.
Liu et al., Cleveland, United States. In Int J Clin Exp Pathol, 2011
RRM2 protein expression in pancreatic adenocarcinoma is neither prognostic nor predictive of adjuvant gemcitabine benefit in patients with resectable pancreatic adenocarcinoma.
Expression status of ribonucleotide reductase small subunits hRRM2/p53R2 as prognostic biomarkers in stage I and II non-small cell lung cancer.
Cheng et al., T'ai-chung-shih, Taiwan. In Anticancer Res, 2011
p53R2 expression seems more important than that of hRRM2 in prognosis of early-stage lung cancer.
The translational regulator eIF3a: the tricky eIF3 subunit!
Richardson et al., Sydney, Australia. In Biochim Biophys Acta, 2010
However, eIF3a may play a role as a regulator of a subset of mRNAs and has been demonstrated to regulate the expression of p27(kip1), tyrosinated α-tubulin and ribonucleotide reductase M2 subunit.
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.
Ribas et al., Pasadena, United States. In Nature, 2010
Furthermore, a reduction was found in both the specific messenger RNA (M2 subunit of ribonucleotide reductase (RRM2)) and the protein (RRM2) levels when compared to pre-dosing tissue.
Metabolic genes in cancer: their roles in tumor progression and clinical implications.
Watabe et al., Springfield, United States. In Biochim Biophys Acta, 2010
We particularly focus on three groups of genes; GLUT1, G6PD, TKTL1 and PGI/AMF in glycolytic pathway, ACLY, ACC1 and FAS in lipogenesis and RRM2, p53R2 and TYMS for nucleotide synthesis.
Genetic factors influencing cytarabine therapy.
Lamba, Minneapolis, United States. In Pharmacogenomics, 2009
Thus, genetic variation in key genes in the ara-C metabolic pathway--specifically, deoxycytidine kinase (a rate-limiting activating enzyme), 5 nucleotidase, cytidine deaminase and deoxycytidylate deaminase (all three are inactivating enzymes), human equilibrative nucleoside transporter (ara-C uptake transporter) and ribonucleotide reductase (RRM1 and RRM2--enzymes regulating intracellular deoxycytidine triphosphate pools)--form the molecular basis of the interpatient variability observed in intracellular ara-CTP concentrations and response to ara-C.
RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer.
Robinson et al., Tampa, United States. In J Clin Oncol, 2004
RNA was extracted from tumor and normal lung tissue, and expression of the genes RRM1, PTEN, and RRM2 was determined by real-time quantitative polymerase chain reaction.
Specific inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit 2.
Langelier et al., In Nature, 1986
The same model probably holds for the herpes simplex virus (HSV)-encoded ribonucleotide reductase; two polypeptides of relative molecular mass 136,000 (136K; H1) and 40K (H2) (referred to elsewhere as RR1 and RR2; see for example, Dutia et al.) have been associated with the viral enzyme by both genetic and immunological studies.
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