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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mitochondrial ribosome recycling factor

RRF, IL-1F7, fil1, IL-1F7b
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, ACID, Serum albumin
Papers on RRF
Complete kinetic mechanism for recycling of the bacterial ribosome.
New
Ehrenberg et al., Uppsala, Sweden. In Rna, Jan 2016
How EF-G and RRF act together to split a post-termination ribosomal complex into its subunits has remained obscure.
The importance of overhydration in determining peritoneal dialysis technique failure and patient survival in anuric patients.
New
Davenport et al., London, United Kingdom. In Int J Artif Organs, Jan 2016
PURPOSE: Loss of residual renal function (RRF) is associated with an increased risk for peritoneal dialysis (PD) technique failure and patient death.
Loss of Residual Renal Function is Associated with Vascular Calcification in Hemodialysis Patients.
New
Huang et al., Taiwan. In Ther Apher Dial, Jan 2016
Loss of residual renal function (RRF) is associated with increased mortality in HD patients.
When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?
Review
New
Scola et al., Curitiba, Brazil. In Arq Neuropsiquiatr, Nov 2015
Morphological changes seen upon muscle biopsy in MELAS include a substantive proportion of ragged red fibers (RRF) and the presence of vessels with a strong reaction for succinate dehydrogenase.
High blood glucose independent of pre-existing diabetic status predicts mortality in patients initiating peritoneal dialysis therapy.
New
Lee et al., Huddinge, Sweden. In Int Urol Nephrol, Jun 2015
METHODS: In 174 PD patients (55 % males, 56 % DM), BG, nutritional status, comorbidity (CMD), and residual renal function (RRF) were assessed in conjunction with dialysis initiation.
Strategies for preserving residual renal function in peritoneal dialysis patients.
New
Davenport et al., Bangkok, Thailand. In Clin Kidney J, Apr 2015
Whereas blood pressure control, using an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB), and low-protein diets along with keto acid supplementation have been shown to reduce the rate of progression in patients with earlier stages of CKD, the strategies to preserve residual renal function (RRF) in dialysis patients are not well established.
Retina derived relaxation is mediated by K(ir) channels and the inhibition of Ca(2+) sensitization in isolated bovine retinal arteries.
New
Özdemir et al., İstanbul, Turkey. In Exp Eye Res, Mar 2015
Retinal relaxing factor (RRF) has recently been identified as a novel paracrine regulator of retinal circulation acting differently from well known mediators of the endothelium and the retina.
Opposing motion inhibits responses of direction-selective ganglion cells in the fish retina.
New
Maximov et al., Moscow, Russia. In J Integr Neurosci, Mar 2015
One of them entered central (responsive) area of cell receptive field (RRF) from the preferred, and the other one from the null side.
Immunobiology of IL-37: mechanism of action and clinical perspectives.
Review
Agrawal et al., Omaha, United States. In Expert Rev Clin Immunol, 2014
This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease.
Effect of benfotiamine in podocyte damage induced by peritoneal dialysis fluid.
Schwenger et al., Heidelberg, Germany. In Front Med (lausanne), 2014
BACKGROUND: In peritoneal dialysis (PD), residual renal function (RRF) fundamentally contributes to improved quality of life and patient survival.
When should MERRF (myoclonus epilepsy associated with ragged-red fibers) be the diagnosis?
Review
Werneck et al., Curitiba, Brazil. In Arq Neuropsiquiatr, 2014
Diagnostic criteria for MERRF include typical manifestations of the disease: myoclonus, generalized epilepsy, cerebellar ataxia and ragged red fibers (RRF) on muscle biopsy.
Glutamate neurons within the midbrain dopamine regions.
Review
Root et al., Baltimore, United States. In Neuroscience, 2014
Within rat retrorubral field (RRF), large populations of VGluT2 neurons are observed throughout its anteroposterior extent.
IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation.
Review
Theoharides et al., In Int J Immunopathol Pharmacol, 2012
Cytokines such as interleukins, chemokines and interferons are immunomodulating and inflammatory agents, characterized by considerable redundancy, in that many cytokines appear to share similar functions.
Interleukin 37 expression protects mice from colitis.
GeneRIF
Rivera-Nieves et al., Aurora, United States. In Proc Natl Acad Sci U S A, 2011
IL-37 is a key modulator of intestinal inflammation, and its expression protects mice from experimental colitis.
Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss.
GeneRIF
Tilg et al., Innsbruck, Austria. In Mol Med, 2010
Data show that weight loss led to a significant reduction in liver IL-1beta, IL-18 and IL-1Ra expression, whereas hepatic IL-37 expression remained stable, adipose/liver NLRP3 inflammasome and IL-1alpha expression were not affected by weight loss.
IL-37 is a fundamental inhibitor of innate immunity.
Impact
GeneRIF
Dinarello et al., Aurora, United States. In Nat Immunol, 2010
IL-37 thus emerges as a natural suppressor of innate inflammatory and immune responses
EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis.
GeneRIF
Takeuchi et al., Kashiwa, Japan. In Mol Cell, 2009
EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis.
The human mitochondrial ribosome recycling factor is essential for cell viability.
GeneRIF
Chrzanowska-Lightowlers et al., Newcastle upon Tyne, United Kingdom. In Nucleic Acids Res, 2008
Depletion of mtRRF in human cell lines is lethal, initially causing profound mitochondrial dysmorphism, aggregation of mitoribosomes and elevated mitochondrial superoxide production.
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Impact
Mello et al., Worcester, United States. In Cell, 2006
Interactors required for endo-siRNA production include ERI-1 and RRF-3, whose loss of function enhances RNAi.
Crystal structure of Thermotoga maritima ribosome recycling factor: a tRNA mimic.
Impact
Liljas et al., Lund, Sweden. In Science, 2000
Ribosome recycling factor (RRF), together with elongation factor G (EF-G), catalyzes recycling of ribosomes after one round of protein synthesis.
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