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Protein tyrosine phosphatase, receptor-type, Z polypeptide 1

RPTPbeta, PTPzeta, Ptprz, PTPRZ1, DSD-1-PG, HPTP beta, RPTPzeta
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Arp2, ACID, CAN, HAD, Tenascin
Papers on RPTPbeta
Molecular identity of human outer radial glia during cortical development.
New
Impact
Kriegstein et al., San Francisco, United States. In Cell, Oct 2015
By analyzing gene expression across single cells, we find that outer radial glia preferentially express genes related to extracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR.
Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.
New
Noda et al., Okazaki, Japan. In J Neurosci, Oct 2015
Protein tyrosine phosphatase receptor type Z (PTPRZ), one of the most abundant protein tyrosine phosphatases expressed in OPCs, is known to suppress oligodendrocyte differentiation and maintain their precursor cell stage.
Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions.
New
Su et al., Beijing, China. In Febs Lett, Jul 2015
In this study, we show that ZM-carrying patients have increased hepatocyte growth factor receptor (MET) mRNA expression levels induced by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1).
Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.
New
Diehl et al., Durham, United States. In Gut, Feb 2015
Perivascular cells in stem cell niches produce pleiotrophin (PTN) to inactivate the PTN receptor, protein tyrosine phosphatase receptor zeta-1 (PTPRZ1), thereby augmenting phosphoprotein-dependent signalling.
Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.
Noda et al., Okazaki, Japan. In Plos One, 2014
We previously demonstrated that Git1 was a multiply tyrosine-phosphorylated protein, its primary phosphorylation site was Tyr-554 in the vicinity of the focal adhesion targeting-homology (FAH) domain, and this site was selectively dephosphorylated by protein tyrosine phosphatase receptor type Z (Ptprz).
The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.
Schinke et al., Hamburg, Germany. In Plos One, 2014
We therefore analyzed the skeletal phenotype of mice lacking Ptprz1, the gene encoding Rptpζ on a tumor-prone genetic background, i.e.
Biomarkers of erlotinib response in non-small cell lung cancer tumors that do not harbor the more common epidermal growth factor receptor mutations.
Sastre et al., Madrid, Spain. In Int J Clin Exp Pathol, 2014
Overlapping groups of 7, 5 and 3 genes, including UGT1A6, TRIB3, MET, MMP7, COL17A1, LCN2 and PTPRZ1, whose expression correlated with erlotinib activity was identified.
Carbonic anhydrase related proteins: molecular biology and evolution.
Review
Parkkila et al., Tampere, Finland. In Subcell Biochem, 2013
The CA-like domains of receptor-type protein tyrosine phosphatases (PTPR) are found only in PTPRG and PTPRZ.
Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase β activity.
GeneRIF
Maret et al., London, United Kingdom. In J Biol Chem, 2012
zinc(II) ions regulate receptor protein-tyrosine phosphatase beta activity at picomolar concentrations.
Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z.
GeneRIF
Noda et al., Okazaki, Japan. In J Biol Chem, 2011
molecular basis for the substrate recognition of Ptprz.
A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells.
GeneRIF
Harroch et al., Paris, France. In Proc Natl Acad Sci U S A, 2011
report the cocrystal structure of the carbonic anhydrase-like domain of PTPRZ bound to tandem Ig repeats of CNTN1 and binding assays to show that PTPRZ binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells
Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function.
GeneRIF
Fisher et al., Ann Arbor, United States. In J Biol Chem, 2011
RPTP-beta is a key regulator of Met function.
Protein tyrosine phosphatases in glioma biology.
Review
Hendriks et al., Nijmegen, Netherlands. In Acta Neuropathol, 2010
So far, the data point to the potential implication of receptor-type (RPTPdelta, DEP1, RPTPmicro, RPTPzeta) and intracellular (PTP1B, TCPTP, SHP2, PTPN13) classical PTPs, dual-specific PTPs (MKP-1, VHP, PRL-3, KAP, PTEN) and the CDC25B and CDC25C PTPs in glioma biology.
Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.
Review
Hirayama et al., Nagasaki, Japan. In Tohoku J Exp Med, 2010
VacA binds to two types of receptor-like protein tyrosine phosphatase (RPTP), RPTPalpha and RPTPbeta, on the surface of host cells.
A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ.
GeneRIF
Katsoris et al., Pátrai, Greece. In Mol Cancer, 2009
results demonstrate that P(122-131) inhibits biological activities that are related to the induction of a transformed phenotype in PCa cells, by interacing with RPTPbeta-zeta and interfering with other pleiotrophin receptors
Chondroitin sulfate proteoglycans in neural development and plasticity.
Review
Ishii et al., Tokyo, Japan. In Front Biosci, 2009
PTPzeta and lectican family members are major chondroitin sulfate proteoglycans (CS-PGs) in the brain, which bind with many proteins via core protein and CS portions.
Blocking receptor protein tyrosine phosphatase beta/zeta: a potential therapeutic strategy for Parkinson's disease.
Review
Ezquerra et al., Madrid, Spain. In Curr Med Chem, 2008
Pleiotrophin induces dimerization of RPTPbeta/zeta inactivating its phosphatase activity, thus increasing the phosphorylation levels of its substrates such as beta-catenin, Fyn and beta-adducin.
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.
Impact
GeneRIF
Noda et al., Okazaki, Japan. In Nat Genet, 2003
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Erroneous Ptprz signaling induces gastric ulcers.
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.
Impact
GeneRIF
Schlessinger et al., New Haven, United States. In Nat Genet, 2002
PTPRZ has a role in oligodendrocyte survival and in recovery from demyelinating disease
The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin.
Impact
Schlessinger et al., Redwood City, United States. In Cell, 1995
Receptor-type protein tyrosine phosphatase beta (RPTP beta) is expressed in the developing nervous system and contains a carbonic anhydrase (CAH) domain as well as a fibronectin type III repeat in its extracellular domain.
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