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Ribosomal protein S3

rps3, ribosomal protein S3
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, SET, V1a, RPS19
Papers using rps3 antibodies
Influence of Ionic Strength, pH, and Chelation of Divalent Metals on Isolation of Polyribosomes from Tobacco Leaves.
Renne Rolf, In PLoS Pathogens, 1975
... (1∶2000, BD Biosciences), mouse monoclonal anti-dsRed (1∶500, Clontech), mouse monoclonal anti-HA (1∶2000, Invitrogen), mouse monoclonal anti-RPS3 (1∶1000, Abcam), mouse monoclonal anti-Flag (1∶1000, ...
Papers on rps3
The complete mitochondrial genome of the nematophagous fungus Lecanicillium saksenae.
Xie et al., Beijing, China. In Mitochondrial Dna, Jan 2016
The mitochondrial genome is 25 919 bp long with 14 typical protein-coding genes, an intronic ORF coding for a putative ribosomal protein (rps3), 2 ribosomal RNA genes and a set of 26 transfer RNA genes.
The plastomes of two species in the endoparasite genus Pilostyles (Apodanthaceae) each retain just five or six possibly functional genes.
Renner et al., München, Germany. In Genome Biol Evol, Jan 2016
Illumina and 454 data and Sanger re-sequencing yielded circularized plastomes of 11,348 and 15,167 bp length, with both species containing five possibly functional genes (accD, rps3, rps4, rrn16, rrn23) and two/three pseudogenes (rpoC2 in P. aethiopica and rpl2 and rps12 in both species; rps12 may be functional in P. hamiltonii).
Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction.
Wan et al., United States. In Febs Lett, Dec 2015
Here we show that the p65(1-97) fragment generated by Caspase-3 cleavage interferes with ribosomal protein S3 (RPS3), an NF-κB "specifier" subunit, and selectively retards the nuclear translocation of RPS3, thus dampening the RPS3/NF-κB-dependent anti-apoptotic gene expression.
The complete mitochondrial genome of mungbean Vigna radiata var. radiata NM92 and a phylogenetic analysis of crops in angiosperms.
Chen et al., Taipei, Taiwan. In Mitochondrial Dna, Nov 2015
Eight protein-coding genes (nad1, nad2, nad4, nad5, nad7, rps3, and rps10) centain introns.
RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling.
Deng et al., Guangzhou, China. In Oncotarget, Nov 2015
In this study, we demonstrated that ribosomal protein S3 (RPS3) was a potential target involved in melanoma growth.
The evolutionary conservation of rps3 introns and rps19-rps3-rpl16 gene cluster in Adiantum capillus-veneris mitochondria.
Regina et al., Cosenza, Italy. In Curr Genet, Sep 2015
This study reports that the gene for the ribosomal protein S3 (rps3) is preserved and physically clustered to an upstream rps19 and a downstream overlapping rpl16 locus in the mitochondrial DNA of the true fern Adiantum capillus-veneris L. Sequence analysis also revealed that the rps3 gene is interrupted by two cis-splicing group II introns, like the counterpart in lycopod and gymnosperm representatives.
Complete mitochondrial genome of a red calcified alga Calliarthron tuberculosum (Corallinales).
Du et al., Qingdao, China. In Mitochondrial Dna, Sep 2015
rps3 and rpl16 also have a 45 bp overlapped region.
Post-transcriptional regulation of ribosomal protein genes during serum starvation in Entamoeba histolytica.
Bhattacharya et al., New Delhi, India. In Mol Biochem Parasitol, Jun 2015
To investigate the regulation of RP genes under stress we measured transcription of six selected RP genes from the small- and large-ribosomal subunits (RPS6, RPS3, RPS19, RPL5, RPL26, RPL30) representing the early-, mid-, and late-stages of ribosomal assembly.
Evaluation of Reference Genes for RT-qPCR in Tribolium castaneum (Coleoptera: Tenebrionidae) Under UVB Stress.
Lei et al., Wuhan, China. In Environ Entomol, Apr 2015
Ribosomal protein genes RpS3, RpL13A, and β-actin gene (ActB) showed the highest stability across all UVB irradiation time points, whereas expression of other normally used reference genes, such as those encoding the β-tubulin gene TUBB and the E-cadherin gene CAD, varied at different developmental stages.
Selection and Evaluation of Tissue Specific Reference Genes in Lucilia sericata during an Immune Challenge.
Franta et al., Gießen, Germany. In Plos One, 2014
We therefore selected 10 candidate reference genes encoding products from different functional classes (18S rRNA, 28S rRNA, actin, β-tubulin, RPS3, RPLP0, EF1α, PKA, GAPDH and GST1).
Rapid evolutionary divergence of Gossypium barbadense and G. hirsutum mitochondrial genomes.
Hua et al., Beijing, China. In Bmc Genomics, 2014
Both mitochondrial genomes contain a duplicated copy of rps3 (rps3-2) in conjunction with a duplication of repeated sequences.
Eukaryotic ribosomal protein S3: A constituent of translational machinery and an extraribosomal player in various cellular processes.
Karpova et al., Novosibirsk, Russia. In Biochimie, 2014
Ribosomal proteins from the S3 family are universal components of small ribosomal subunits in all three domains of life.
Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.
McBride et al., Los Angeles, United States. In Biochemistry, 2012
Rps3 is stoichiometrically modified by omega-monomethylation at arginine-146 and is associated with slow cell growth.
Yar1 protects the ribosomal protein Rps3 from aggregation.
Pertschy et al., Graz, Austria. In J Biol Chem, 2012
Yar1 is a specific chaperone for Rps3, which serves to keep Rps3 soluble until its incorporation into the pre-ribosome
Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
rpS3 is recruited to the DISC and plays a critical role in both genotoxic stress and cytokine induced apoptosis.
Yeast ribosomal protein S3 possesses a β-lyase activity on damaged DNA.
Kim et al., Seoul, South Korea. In Febs Lett, 2012
Rps3p has a beta-lyase activity with a broad range of substrate specificity which cleaves phosphodiester bonds of UV or oxidatively damaged DNA substrates.
Ribosomal protein S3 is stabilized by sumoylation.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2011
rpS3 is covalently modified by SUMO-1 and this post-translational modification regulates rpS3 function by increasing rpS3 protein stability.
IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7.
Lenardo et al., Bethesda, United States. In Nat Immunol, 2011
Data show that the IKKbeta-dependent modification of a specific amino acid in RPS3 promoted specific NF-kappaB functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7.
The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives.
Lenardo et al., Bethesda, United States. In Cell Res, 2010
A non-Rel subunit of NF-kappaB, ribosomal protein S3 (RPS3), and numerous other nuclear regulators of NF-kappaB, including Akirin, Nurr1, SIRT6, and others, have recently been identified, unveiling novel and exciting layers of regulatory specificity for NF-kappaB in the nucleus.
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.
Lenardo et al., Bethesda, United States. In Cell, 2007
RPS3 is an essential but previously unknown subunit of NF-kappaB involved in the regulation of key genes in rapid cellular activation responses.
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