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Ribosomal protein S17

RPS17, ribosomal protein S17, HCF60
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RPS19, ribosomal protein L11, ACID, p31, HAD
Papers on RPS17
Clinical and genomic heterogeneity of Diamond Blackfan anemia in the Russian Federation.
Maschan et al., Moscow, Russia. In Pediatr Blood Cancer, Sep 2015
Genomic DNA from 57 DBA patients and their first-degree relatives was sequenced for mutations in RPS19, RPS10, RPS24, RPS26, RPS7, RPS17, RPL5, RPL11, RPL35a, and GATA1.
[Molecular mechanisms underlying the pathology of Diamond-Blackfan anemia].
Ito et al., Hirosaki, Japan. In Rinsho Ketsueki, Jul 2015
In DBA, mutations or large deletions in RP genes include RPS7, RPS10, RPS17, RPS19, RPS24, RPS26, RPL5, RPL11, RPL26 and RPL35A.
Evaluation of Salivary Transcriptome Markers for the Early Detection of Oral Squamous Cell Cancer in a Prospective Blinded Trial.
Swanick et al., Lansing, United States. In Compend Contin Educ Dent, May 2015
Six pre-specified oral-cancer-associated mRNAs (IL1β, IL8, OAZ1, SAT, S100P, and DUSP1) and five housekeeping mRNAs (MT-ATP6, RPL30, RPL37A, RPL0, and RPS17) were measured by quantitative polymerase chain reaction (PCR) without knowledge of tissue diagnosis.
The lysine residues within the human ribosomal protein S17 sequence naturally inserted into the viral nonstructural protein of a unique strain of hepatitis E virus are important for enhanced virus replication.
Meng et al., Blacksburg, United States. In J Virol, Apr 2015
The adaptation of the Kernow C-1 P6 HEV to propagate in HepG2C3A cells selected for a rare virus recombinant that contains an insertion of a 171-nucleotide sequence encoding amino acids 21 to 76 of the human ribosomal protein S17 (RPS17) within the hypervariable region (HVR) of the HEV ORF1 protein.
Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.
Ito et al., Hirosaki, Japan. In Br J Haematol, Mar 2015
The disease has been associated with mutations or large deletions in 11 ribosomal protein genes including RPS7, RPS10, RPS17, RPS19, RPS24, RPS26, RPS29, RPL5, RPL11, RPL26 and RPL35A as well as GATA1 in more than 50% of patients.
Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17.
Meng et al., Blacksburg, United States. In Plos One, 2014
Human ribosomal protein S17 (RPS17) is mutated in Diamond-Blackfan Anemia (DBA), a bone marrow disorder that fails to produce sufficient red blood cells leading to anemia.
Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia.
Park et al., Seoul, South Korea. In Exp Mol Med, 2013
In this study, nine Korean DBA patients were screened for mutations in eight known DBA genes (RPS19, RPS24, RPS17, RPS10, RPS26, RPL35A, RPL5 and RPL11) using the direct sequencing method.
Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19.
Lin et al., Beijing, China. In Cell Death Dis, 2013
Approximately, 25% of patients carry a mutation in the ribosomal protein (RP) S19 gene; mutations in RPS24, RPS17, RPL35A, RPL11, and RPL5 have been reported.
The importance of the 45 S ribosomal small subunit-related complex for mitochondrial translation in Trypanosoma brucei.
Maslov et al., Riverside, United States. In J Biol Chem, 2013
To investigate the function of this complex, PPR29, Rhod, 200-kDa protein, and mitochondrial ribosomal protein S17 were knocked down by RNAi in procyclic T. brucei.
Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia.
Gazda et al., Boston, United States. In Hum Genet, 2013
The disease has been associated with point mutations and large deletions in ten ribosomal protein (RP) genes RPS19, RPS24, RPS17, RPL35A, RPL5, RPL11, RPS7, RPS10, RPS26, and RPL26 and GATA1 in about 60-65 % of patients.
Tissue-based microarray expression of genes predictive of metastasis in uveal melanoma and differentially expressed in metastatic uveal melanoma.
Elner et al., United States. In J Ophthalmic Vis Res, 2013
PURPOSE: To screen the microarray expression of CDH1, ECM1, EIF1B, FXR1, HTR2B, ID2, LMCD1, LTA4H, MTUS1, RAB31, ROBO1, and SATB1 genes which are predictive of primary uveal melanoma metastasis, and NFKB2, PTPN18, MTSS1, GADD45B, SNCG, HHIP, IL12B, CDK4, RPLP0, RPS17, RPS12 genes that are differentially expressed in metastatic uveal melanoma in normal whole human blood and tissues prone to metastatic involvement by uveal melanoma.
[Analysis of mutations of ribosomal protein genes in 21 cases of Diamond-Blackfan anemia].
Zhu et al., Tianjin, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2012
Twenty-one cases of DBA admitted in our hospital from Dec 2008 to Aug 2012 were screened by PCR for mutations in the nine known genes associated with DBA: RPS19, RPS24, RPS17, RPL5, RPL11, RPS7, RPL35a, RPS10 and RPS26.
High frequency of ribosomal protein gene deletions in Italian Diamond-Blackfan anemia patients detected by multiplex ligation-dependent probe amplification assay.
Ramenghi et al., Torino, Italy. In Haematologica, 2012
As a proof of concept, we designed a multiplex ligation-dependent probe amplification assay targeted to screen the six genes that are most frequently mutated in Diamond-Blackfan anemia patients: RPS17, RPS19, RPS26, RPL5, RPL11, and RPL35A.
Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.
Emerson et al., Bethesda, United States. In J Virol, 2012
Human S17 insertion was a major factor for hepatitis E virus in cell culture adaptation.
Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia.
Hamaguchi et al., Tokyo, Japan. In Blood, 2012
Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A deletion, 3 with RPS17 deletions, and 1 with an RPS19 deletion.
Ribosomal protein gene deletions in Diamond-Blackfan anemia.
Bodine et al., Baltimore, United States. In Blood, 2012
Studies identified deletions at known Diamond-Blackfan anemia (DBA)-related ribosomal protein gene loci in 17% (9 of 51) of patients without an identifiable mutation, including RPS19, RPS17, RPS26, and RPL35A.
Untangling the phenotypic heterogeneity of Diamond Blackfan anemia.
Dahl et al., Baltimore, United States. In Semin Hematol, 2011
Recent advances in identifying the genetic abnormalities underlying DBA have demonstrated involvement of genes encoding both large (RPL) and small (RPS) ribosomal subunit proteins, including mutations of RPL5, RPL11, RPL35A, RPS7, RPS10, RPS17, RPS19, RPS24, and RPS26 in 50% to 60% of affected patients.
RPS19 mutations in patients with Diamond-Blackfan anemia.
Dianzani et al., Torino, Italy. In Hum Mutat, 2008
Twenty-five percent (25%) of patients carry a mutation in the ribosomal protein (RP) S19 gene, whereas mutations in RPS24, RPS17, RPL35A, RPL11, and RPL5 are rare.
Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia.
Pospisilova et al., Praha, Czech Republic. In Hum Mutat, 2007
Data show in Diamond-Blackfan anemia, mutation in RPS17 wasn detected and the mutation affects the translation initiation start codon, changing T to G (c.2T>G), thus eliminating the natural start of RPS17 protein biosynthesis
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