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Mitochondrial ribosomal protein S12

rps12, ribosomal protein S12, mitochondrial ribosomal protein S12
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: 5-HT1B, ACID, CAN, fibrillin-1, POLYMERASE
Papers on rps12
Detecting and characterizing the highly divergent plastid genome of the nonphotosynthetic parasitic plant Hydnora visseri (Hydnoraceae).
dePamphilis et al., Fullerton, United States. In Genome Biol Evol, Feb 2016
Active transcription is detected for all of the protein coding genes in the plastid genome, and one of two introns is appropriately spliced out of rps12 transcripts.
The complete chloroplast genome sequence of Cunninghamia lanceolata.
Huang et al., Guangzhou, China. In Mitochondrial Dna, Feb 2016
Twelve protein-coding genes (rps16, ycf3, rpoC1, atpF, rps12, ndhB, rpl2, rpl16, petD, petB, ndhA, rps15) contain one or two introns.
Two complete chloroplast genomes of white campion (Silene latifolia) from male and female individuals.
Tembrock et al., Fort Collins, United States. In Mitochondrial Dna, Jan 2016
In these protein-coding genes, eight genes (rpl16, rpoC1, rps16, petD, petB, ndhB, ndhA and atpF) contain a single intron and three genes (rps12, clpP and ycf3) contain two introns.
The plastomes of two species in the endoparasite genus Pilostyles (Apodanthaceae) each retain just five or six possibly functional genes.
Renner et al., München, Germany. In Genome Biol Evol, Jan 2016
Illumina and 454 data and Sanger re-sequencing yielded circularized plastomes of 11,348 and 15,167 bp length, with both species containing five possibly functional genes (accD, rps3, rps4, rrn16, rrn23) and two/three pseudogenes (rpoC2 in P. aethiopica and rpl2 and rps12 in both species; rps12 may be functional in P. hamiltonii).
Conditional repression of essential chloroplast genes: Evidence for new plastid signaling pathways.
Ramundo et al., Genève, Switzerland. In Biochim Biophys Acta, Sep 2015
This approach has been used to analyze three chloroplast genes of this sort coding for the α subunit of RNA polymerase (rpoA), a ribosomal protein (rps12) and the catalytic subunit of the ATP-dependent ClpP protease (clpP1).
Gene Loss and Error-Prone RNA Editing in the Mitochondrion of Perkinsela, an Endosymbiotic Kinetoplastid.
Lukeš et al., České Budějovice, Czech Republic. In Mbio, 2014
We have sequenced the highly reduced mitochondrial genome of Perkinsela, which possesses only six protein-coding genes (cox1, cox2, cox3, cob, atp6, and rps12), despite the fact that the organelle itself contains more DNA than is present in either the host or endosymbiont nuclear genomes.
Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen.
Lun et al., Guangzhou, China. In Parasit Vectors, 2014
The high GC content in at least 9 maxicircle genes of T. lewisi (ATPase6; NADH dehydrogenase subunits ND3, ND7, ND8 and ND9; G-rich regions GR3 and GR4; cytochrome oxidase subunit COIII and ribosomal protein RPS12) implies that their products may be extensively edited.
NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells.
Jacobs et al., Tampere, Finland. In Biochim Biophys Acta, 2009
NF-Y type CCAAT boxes are found preferentially in bidirectional Mrps12/Sarsm promoters, but many such promoters lack them and must be regulated in another way.
Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.
Ochi et al., Tsukuba, Japan. In Nat Biotechnol, 2009
The antibacterial-producing mutants all carried mutations in RNA polymerase and/or the ribosomal protein S12.
cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.
Russo et al., Napoli, Italy. In Biochim Biophys Acta, 2008
mitochondrial ribosomal protein S12 3'-UTR interacts specifically with TRAP1 (tumor necrosis factor receptor-associated protein1), hnRNPM4 (heterogeneous nuclear ribonucleoprotein M4), Hsp70 and Hsp60 (heat shock proteins 70 and 60), and alpha-tubulin
Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Gerstein et al., New Haven, United States. In Genomics, 2003
Homo sapiens mitochondrial ribosomal protein S12
Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix.
Hui et al., Singapore, Singapore. In Br J Cancer, 2002
may be early molecular diagnostic marker for cervical squamous cell carcinoma
Genetic factors in aminoglycoside toxicity.
Fischel-Ghodsian, Los Angeles, United States. In Ann N Y Acad Sci, 1999
Another candidate gene is the mitochondrial ribosomal protein S12, which interacts with the ribosomal RNA gene and in bacteria can harbor aminoglycoside resistance mutations.
RNA editing site recognition in higher plant mitochondria.
Shanahan et al., Irvine, United States. In J Hered, 1999
The cis-acting sequences for editing site recognition have been examined in ribosomal protein S12 (rps12) transcripts and in transcripts for a second copy of an internal portion of the ribosomal protein S12 (rps12b).
[Mechanisms of drug-resistance in mycobacteria].
Kohno et al., In Nihon Rinsho, 1998
In addition, it was reported that point mutations in 16S rRNA gene (rrs) and ribosomal protein S12 gene (rpsL) induced M. tuberculosis as streptomycin (SM) resistant phenotype.
Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.
Musser et al., Houston, United States. In Tuber Lung Dis, 1997
Streptomycin resistance is due mainly to mutations in the 16S rRNA gene or the rpsL gene encoding ribosomal protein S12.
The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editing.
Simpson et al., Los Angeles, United States. In Cell, 1992
The pan-edited RPS12 mRNA is edited by seven minicircle-encoded gRNAs and one maxicircle-encoded gRNA.
The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12.
Jan et al., San Francisco, United States. In Cell, 1987
Their sequence implies a protein product composed of 140 amino acids, which exhibits considerable sequence similarity to ribosomal protein S12 from both Euglena gracilis chloroplasts and E. coli.
Evidence for in vivo trans splicing of pre-mRNAs in tobacco chloroplasts.
Edelman et al., In Cell, 1987
The rps12 gene codes for chloroplast ribosomal protein S12.
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