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Ribosomal protein L39-like

RPL39L, L39-2, ribosomal protein L39-like
This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, leptin, CKS2, TOP, CDC2
Papers on RPL39L
RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors.
Vardy et al., Singapore, Singapore. In Rna Biol, 2013
We find the RP paralog Rpl39l is highly expressed in ESC and its expression strongly correlates with hepatocellular carcinoma tumor (HCC) samples with high tumor grading and alpha-fetoprotein level giving it diagnostic potential.
Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia.
Kwabi-Addo et al., Washington, D.C., United States. In Prostate Cancer Prostatic Dis, 2013
Of the 33 genes, hierarchical clustering analysis demonstrated BNC1, FZD1, RPL39L, SYN2, LMX1B, CXXC5, ZNF783 and CYB5R2 as top candidate novel genes that are frequently methylated and whose methylation was associated with inactivation of gene expression in PCa cell lines.
The four hydrophobic residues on the Hsp70 inter-domain linker have two distinct roles.
Liu et al., Richmond, United States. In J Mol Biol, 2011
In DnaK, a well-studied Hsp70, these residues are V389, L390, L391, and L392.
Fatty diabetic lung: functional impairment in a model of metabolic syndrome.
Hsia et al., Dallas, United States. In J Appl Physiol, 2010
The Zucker diabetic fatty (ZDF fa/fa) rat with genetic leptin insensitivity develops obesity and Type 2 diabetes mellitus (T2DM) with age accompanied by hyperplastic changes in the distal lung (Am J Physiol Lung Cell Mol Physiol 298: L392-L403, 2010).
Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like.
Nadano et al., Nagoya, Japan. In J Proteome Res, 2010
Although the vast majority are considered to be pseudogenes, mRNA expression of a few paralogues, such as human ribosomal protein L39-like/L39-2, has been reported.
C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.
Pays et al., Brussels, Belgium. In Plos Pathog, 2009
However, mutants in the L370-L392 leucine zipper also lost in vitro trypanolytic activity.
Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
Bishop et al., Houston, United States. In Plos One, 2008
We tested for the expression of five of the known retrogenes, UTP14C, PGK2, RPL10L, RPL39L and UBL4B in normal human ovary and ovarian cancers.
Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray.
Smith et al., Hong Kong, Hong Kong. In Int J Cancer, 2006
Several of the genes that were differentially regulated included SPP1 (Osteopontin), CDKN2A (p16), RPL39L, Clorf1, MAL, p11, ARS and NICE-1.
Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.
Kenmochi et al., Okinawa, Japan. In Nucleic Acids Res, 2003
Here we describe functional autosomal copies of the X-linked human RP genes, which we designated RPL10L (ribosomal protein L10-like gene), RPL36AL and RPL39L after their progenitors.
A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells.
GeneRIF
Sato et al., Nagoya, Japan. In Biochim Biophys Acta, 2002
locus, structure and expression of the gene and its relevance to the biological activities of the ribosome
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