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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RPL3 Rpl3p

RPL3, TCM1, ribosomal protein L3, l-4, mak8
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, POLYMERASE, STEP
Papers on RPL3
Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53.
Russo et al., Napoli, Italy. In Cell Cycle, Feb 2016
Here, we demonstrate that ribosomal stress induced by Actinomycin D (Act D) is associated to the up-regulation of ribosomal protein L3 (rpL3) and its accumulation as ribosome-free form in lung and colon cancer cell lines devoid of p53.
Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers.
Raushel et al., College Station, United States. In Biochemistry, Jan 2016
strain TCM1 (Sb-PTE) has recently been reported to catalyze the hydrolysis of organophosphorus flame retardants.
Identification of A2059G 23S rRNA and G439A rplC gene mutations in Streptococcus criceti strain OMZ 61, a strain resistant to azithromycin, josamycin and clindamycin.
Kato et al., In Genes Genet Syst, Jan 2016
We further analyzed the nucleotide sequences of a ribosomal RNA operon, the rrnD operon, and the rpsJ-rpsQ region including rplC and rplD genes for ribosomal proteins L3 and L4, respectively, in the four strains studied.
Characterisation of clinical meticillin-resistant Staphylococcus epidermidis demonstrating high levels of linezolid resistance (>256 μg/ml) resulting from transmissible and mutational mechanisms.
O'Mahony et al., Cork, Ireland. In J Infect Chemother, Jul 2015
The MRSE ST-2 clone isolated from eight patients (2010-2011) not only possessed resistance-conferring mutations such as G2576T in domain V of 23S rRNA gene (as determined by HRM-PCR analysis) and R172C substitution in the ribosomal protein L3, but also carried the cfr gene (the only known transmissible mechanism of LZD resistance).
PCR and microsatellite analysis of diminazene aceturate resistance of bovine trypanosomes correlated to knowledge, attitude and practice of livestock keepers in South-Western Ethiopia.
Delespaux et al., Jīma, Ethiopia. In Acta Trop, Jun 2015
All T. congolense savannah type were analyzed using microsatellite markers TCM1, TCM3 and TCM4.
Ribosomal protein L3 mutations are associated with cfr-mediated linezolid resistance in clinical isolates of Staphylococcus cohnii.
Xiao et al., Beijing, China. In Curr Microbiol, Jun 2015
Moreover, all the five isolates had ribosomal protein L3 mutations, which had different coordinate effect on cfr-mediated linezolid resistance directly through the substitution of serine 158 by phenylalanine or tyrosine in L3 protein.
Molecular characterization of linezolid-resistant CoNS isolates in Japan.
Yamamoto et al., Chiba, Japan. In J Antimicrob Chemother, Mar 2015
METHODS: Staphylococcus capitis strains exhibiting linezolid MICs >8 mg/L isolated from inpatients between 2012 and 2014 were screened for cfr and mutations in 23S rRNA, L3 and L4 by PCR/sequencing.
Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance.
Gudjonsson et al., Ann Arbor, United States. In Genome Med, 2014
Ribosomal subunit and translation proteins were elevated within lesions, without a corresponding shift in mRNA expression (RPL3, RPS8, RPL11).
Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes.
Aravindan et al., Oklahoma City, United States. In Bmc Cancer, 2014
Array CGH analysis of individual clones of MSDACs revealed genetic alterations in chromosomes 1, 7, 8, and 22, corresponding to a gain in the copy numbers of LOC100288142, CD1C, CFHR3, FOXP2, MDFIC, RALYL, CSMD3, SAMD12-AS1, and MAL2, and a loss in ADAM5, LOC400927, APOBEC3B, RPL3, MGAT3, SLC25A17, EP300, L3MBTL2, SERHL, POLDIP3, A4GALT, and TTLL1.
Topological centrality-based identification of hub genes and pathways associated with acute viral respiratory infection in infants.
Zhao et al., Jinan, China. In Genet Mol Res, 2014
Six hub genes namely RPL6, RPL3, EEF1B2, RPL15, EEF1A1, and RPS2, which were identified based on the topological centrality measures, were evaluated further.
Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance.
Vester et al., Odense, Denmark. In Antimicrob Agents Chemother, 2014
In recent years, there has been a rise in the number of studies where mutations have been found in the ribosomal protein L3 in bacterial strains resistant to PTC-targeting antibiotics but there is often no evidence that these mutations actually confer antibiotic resistance.
Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP.
Russo et al., Napoli, Italy. In Oncotarget, 2014
Here, we demonstrate that in lung and colon cancer cell lines devoid of p53, the efficacy of 5-FU and L-OHP chemotherapy depends on rpL3 status.
Haloalkylphosphorus hydrolases purified from Sphingomonas sp. strain TDK1 and Sphingobium sp. strain TCM1.
Kera et al., Nagaoka, Japan. In Appl Environ Microbiol, 2014
strain TCM1 that hydrolyze tri(haloalkyl)phosphates, and we named these enzymes haloalkylphosphorus hydrolases (TDK-HAD and TCM-HAD, respectively).
Identification of rickettsiae from wild rats and cat fleas in Malaysia.
Kho et al., Kuala Lumpur, Malaysia. In Med Vet Entomol, 2014
TCM1 strain from two rats.
Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP.
Russo et al., Napoli, Italy. In Nucleic Acids Res, 2011
NPM and KHSRP are two newly identified proteins involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing.
A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase.
Clarke et al., Los Angeles, United States. In J Biol Chem, 2010
3-methylhistidine modification of Rpl3 is dependent upon the YIL110W methyltransferase.
hnRNP H1 and intronic G runs in the splicing control of the human rpL3 gene.
Russo et al., Napoli, Italy. In Biochim Biophys Acta, 2010
working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site
Functional analysis of Saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis.
de la Cruz et al., Sevilla, Spain. In Nucleic Acids Res, 2006
Upon depletion of Rpl3p, early assembly of 60S ribosomal subunits is aborted and subsequent steps during their maturation and export prevented.
Identification of Saccharomyces cerevisiae ribosomal protein L3 as a target of curvularol, a G1-specific inhibitor of mammalian cells.
Miyakawa et al., Hiroshima, Japan. In Biosci Biotechnol Biochem, 2006
A mutant gene responsible for curvularol resistance was identified as an allele of the RPL3 gene encoding the ribosomal protein L3.
Yeast use translational control to compensate for extra copies of a ribosomal protein gene.
Warner et al., In Cell, 1982
In an attempt to establish the mechanisms responsible for such balanced synthesis we have altered the gene dosage for one of the components by introducing into yeast an autonomously replicating plasmid containing the gene tcm1, which codes for ribosomal protein L3.
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