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Ribosomal protein L27a

RPL27A, ribosomal protein L27a
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, POLYMERASE, ribosomal protein S18, ribosomal protein S29
Papers on RPL27A
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Impact
Schofield et al., Oxford, United Kingdom. In Nature, 2014
In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively.
Multiple marker effects of single nucleotide polymorphisms in three genes, AKIRIN2, EDG1 and RPL27A, for marbling development in Japanese Black cattle.
Yamada et al., Ibaraki, Japan. In Anim Sci J, 2014
We previously detected three single nucleotide polymorphisms (SNPs) associated with BMS number of Japanese Black in Oita prefecture: c.*188G>A in AKIRIN2, g.1471620G>T in EDG1 and g.3109537C>T in RPL27A.
A multilocus phylogeny of the world Sycoecinae fig wasps (Chalcidoidea: Pteromalidae).
van Noort et al., France. In Plos One, 2012
Here, we analysed two mitochondrial (COI, Cytb) and four nuclear genes (ITS2, EF-1α, RpL27a, mago nashi) from a worldwide sample of 56 sycoecine species.
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
Schofield et al., Oxford, United Kingdom. In Nat Chem Biol, 2012
Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively.
What model organisms and interactomics can reveal about the genetics of human obesity.
Review
Schiöth et al., Uppsala, Sweden. In Cell Mol Life Sci, 2012
Here, we searched biological databases and discovered 33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, TUB, ZNF608, FAIM2, KCTD15, LINGO2, POC5, PTBP2, TMEM18, TMEM160).
Potential biological insights revealed by an integrated assessment of proteomic and transcriptomic data in human colorectal cancer.
Mori et al., Suita, Japan. In Int J Oncol, 2012
A relatively large number of upregulated proteins were related to the two principal pathways; ECM receptor interaction was related to heparan sulfate proteoglycan 2 and vitronectin, and ribosome to RPL13, RPL27A, RPL4, RPS18, and RPS29.
Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.
Box et al., Aurora, United States. In J Pathol, 2011
We present a mutation in the ribosomal protein Rpl27a gene (sooty foot ataxia mice), isolated through a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for p53 pathway defects, that shares striking phenotypic similarities with high p53 mouse models, including cerebellar ataxia, pancytopenia and epidermal hyperpigmentation.
Distribution of allele frequencies at TTN g.231054C > T, RPL27A g.3109537C > T and AKIRIN2 c.*188G > A between Japanese Black and four other cattle breeds with differing historical selection for marbling.
Yamada et al., Niigata, Japan. In Bmc Res Notes, 2010
Our previous study detected 3 single nucleotide polymorphisms (SNPs), g.231054C > T, g.3109537C > T and c.*188G > A, respectively, in the 5' flanking region of the titin (TTN), the 5' flanking region of the ribosomal protein L27a (RPL27A) and the 3' untranslated region of the akirin 2 genes (AKIRIN2), which have been considered as positional functional candidates for the genes responsible for marbling, and showed association of these SNPs with marbling in Japanese Black beef cattle.
Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia.
Gazda et al., Boston, United States. In Am J Hum Genet, 2010
To continue our large-scale screen of RP genes in a DBA population, we sequenced 35 ribosomal protein genes, RPL15, RPL24, RPL29, RPL32, RPL34, RPL9, RPL37, RPS14, RPS23, RPL10A, RPS10, RPS12, RPS18, RPL30, RPS20, RPL12, RPL7A, RPS6, RPL27A, RPLP2, RPS25, RPS3, RPL41, RPL6, RPLP0, RPS26, RPL21, RPL36AL, RPS29, RPL4, RPLP1, RPL13, RPS15A, RPS2, and RPL38, in our DBA patient cohort of 117 probands.
Association of a single nucleotide polymorphism in ribosomal protein L27a gene with marbling in Japanese Black beef cattle.
Sasaki et al., Kyoto, Japan. In Anim Sci J, 2009
Thus, the ribosomal protein L27a (RPL27A) gene containing the c2-11#2 EST sequence was considered as a positional candidate for the gene responsible for marbling.
Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia.
Schacher et al., New York City, United States. In J Neurosci, 2009
Moreover, the expression of both the AprpL27a (Aplysia ribosomal protein L27a) and the ApE2N (Aplysia ubiquitin-conjugating enzyme E2N) mRNAs also increased after 5-HT.
Expression profiling of fecal colonocytes for RNA-based screening of colorectal cancer.
Sasaki et al., Tokyo, Japan. In Int J Oncol, 2007
Six genes (SEPP1, RPL27A, ATP1B1, EEF1A1, SFN, and RPS11) selected randomly from 85 cancer patient-derived colonocyte-specific genes were evaluated.
Polymorphisms for 7 expressed sequence tags showing marbling-associated expression changes.
Sasaki et al., Tsukuba, Japan. In Res Commun Mol Pathol Pharmacol, 2006
The SNP in the ribosomal protein L27a (RPL27A) gene containing the c2-11#2 EST sequence may be related to changes in gene expression and/or marbling.
Gene expression profiles of U937 human macrophages exposed to Chlamydophila pneumoniae and/or low density lipoprotein in five study models using differential display and real-time RT-PCR.
Chow et al., Singapore, Singapore. In Biochimie, 2006
In relation to atherosclerosis, some interesting modified transcripts are involved in cell proliferation (CDC2, CDC27, CDC42EP3, GBDR1, GPR6, RPL27A, Similar to COX2), apoptosis (BCL2A1), ubiquitination (CTSH, HSPC150, NUC2), and structural integrity (ACTG1, FLOT1).
Entamoeba histolytica: Characterization of human collagen type I and Ca2+ activated differentially expressed genes.
Das et al., Calcutta, India. In Exp Parasitol, 2005
Sequence analyses and database searches revealed homology with known virulence factor genes of E. histolytica such as amoebapore C and cysteine proteinase 5, along with stress-induced protein HSP70, and ribosomal protein L27a (known to be involved in protein synthesis).
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