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Ribosomal protein L23a

RPL23A, ribosomal protein L23a
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Histone, OUT
Papers on RPL23A
First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex.
New
Bates et al., Lancaster, United Kingdom. In Int J Parasitol, Sep 2015
Three isolates were successfully cultured and DNA sequences from these were analysed (ribosomal RNA internal transcribed spacer 1; ribosomal protein L23a intergenic spacer; RNA polymerase II large subunit), showing them to be Leishmania, identical to each other but different from all other known Leishmania spp.
Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by Leishmania martiniquensis in two patients from northern Thailand infected with HIV.
New
Bates et al., Chiang Mai, Thailand. In Br J Dermatol, Sep 2015
Parasitological diagnosis was performed by establishment of Leishmania promastigote cultures, and identification was performed by DNA sequencing of four independent gene loci (ribosomal RNA internal transcribed spacer 1; large subunit of RNA polymerase II; heat shock protein 70; RPL23a intergenic sequence).
Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.
New
Mahalingam et al., Chennai, India. In J Biol Chem, Sep 2015
Furthermore, our data suggest that ribosomal protein RPL23A interacts with NGP-1 and abolishes NGP-1-induced p53 activity by enhancing Mdm2-mediated p53 polyubiquitination.
Cloning and characterization of a ribosomal protein L23a gene from Small Tail Han sheep by screening of a cDNA expression library.
Ma et al., Beijing, China. In Meta Gene, 2014
As an indispensable component of the eukaryotic ribosome, ribosomal protein L23a plays an important role in protein synthesis, folding and sorting.
The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer.
Leach et al., Baltimore, United States. In Zebrafish, 2014
We, therefore, functionally interrogated the ability of two ribosomal proteins, rpl36 and rpl23a, to alter the response to oncogenic Kras in pancreatic acinar cells using a newly established model of zebrafish pancreatic cancer.
Cytosolic targeting factor AKR2A captures chloroplast outer membrane-localized client proteins at the ribosome during translation.
Hwang et al., South Korea. In Nat Commun, 2014
The targeting signal of a nascent AKR2A client protein residing in the ribosomal exit tunnel induces AKR2A binding to ribosomal RPL23A.
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.
Impact
Sakaguchi et al., Kyoto, Japan. In Science, 2014
One of them was the ubiquitously expressed 60S ribosomal protein L23a (RPL23A), with which T cells and autoantibodies from RA patients reacted.
Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing.
Sun et al., Beijing, China. In Bmc Genomics, 2013
VEGFA, PTHLH, and RPL23A were the most promising candidate genes affecting milk protein and fat percentage.
MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia.
den Boer et al., Rotterdam, Netherlands. In Leuk Res, 2013
Co-expression of these miRNAs resulted in downregulation of DNTT, NUCKS1, MALAT1, SNRPE, PNO1, SET, KIF5B, PRPS2, RPS11, RPL38 and RPL23A (fold-change 1.3-1.9,
Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development.
Leach et al., Baltimore, United States. In Zebrafish, 2013
Utilizing two available mutant lines, rpl23a(hi2582) and rpl6(hi3655b), we found that ptf1a-expressing pancreatic progenitors fail to properly expand in embryos homozygous for either of these genes.
Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.
Beggs et al., Boston, United States. In Hum Mutat, 2012
We completed a large-scale screen of 79 RP genes by sequencing 16 RP genes (RPL3, RPL7, RPL8, RPL10, RPL14, RPL17, RPL19, RPL23A, RPL26, RPL27, RPL35, RPL36A, RPL39, RPS4X, RPS4Y1, and RPS21) in 96 DBA probands.
cDNA cloning, overexpression, purification and pharmacologic evaluation for anticancer activity of ribosomal protein L23A gene (RPL23A) from the Giant Panda.
Su et al., Nanchong, China. In Int J Mol Sci, 2011
The purpose of this paper was to explore the structure and anti-cancer function of ribosomal protein L23A (RPL23A) gene of the Giant Panda (Ailuropoda melanoleuca).
Sequence context for transcription and translation of the Arabidopsis RPL23aA and RPL23aB paralogs.
GeneRIF
Bonham-Smith et al., Saskatoon, Canada. In Genome, 2011
core promoter elements couple RPL23aA and RPL23aB expression to the physiological status of the cell and hence are sufficient for inducing expression in mitotically active tissues and repressing expression in response to negative growth stimuli.
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
Jacinto et al., United States. In Embo J, 2011
In this study, we find that mTORC2 can colocalize with actively translating ribosomes and can stably interact with rpL23a, a large ribosomal subunit protein present at the tunnel exit.
Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani.
Dube et al., Lucknow, India. In Br J Clin Pharmacol, 2010
The major proteins in the membrane-enriched fraction were ABC transporter, HSP-83, GPI protein transamidase, cysteine-leucine rich protein and 60S ribosomal protein L23a whereas in the cytosolic fraction proliferative cell nuclear antigen (PCNA), proteasome alpha 5 subunit, carboxypeptidase, HSP-70, enolase, fructose-1,6-bisphosphate aldolase, tubulin-beta chain have been identified.
Transcript profiling demonstrates absence of dosage compensation in Arabidopsis following loss of a single RPL23a paralog.
GeneRIF
Bonham-Smith et al., Saskatoon, Canada. In Planta, 2008
Patterns of RPL23aA and RPL23aB transcript accumulation in wildtype plants suggest that paralogs respond coordinately to developmental and stress stimuli.
Functional conservation between structurally diverse ribosomal proteins from Drosophila melanogaster and Saccharomyces cerevisiae: fly L23a can substitute for yeast L25 in ribosome assembly and function.
GeneRIF
Ware et al., Bethlehem, United States. In Nucleic Acids Res, 2006
In order to test the function of D. melanogaster L23a and to gain insight into the interchangeability of L23 ribosomal components, D. melanogaster L23a was substituted for yeast L25 in ribosome assembly and function.
A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast.
GeneRIF
Clarke et al., Los Angeles, United States. In J Biol Chem, 2005
The ribosomal large subunit protein L23a, encoded by the Rpl23a and Rpl23b genes, is modified by the SET domain methyltransferase Rkm1.
The two ribosomal protein L23A genes are differentially transcribed in Arabidopsis thaliana.
GeneRIF
Bonham-Smith et al., Saskatoon, Canada. In Genome, 2005
In all tissues examined, RPL23A-2 transcript levels are consistently lower than those of RPL23A-1.
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