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Ribosomal protein L10a

RPL10a, ribosomal protein L10a, Csa-19, sac52, RP-L10
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, rps12, CsA, CAN, POLYMERASE
Papers on RPL10a
CED-4 is an mRNA-binding protein that delivers ced-3 mRNA to ribosomes.
Nakagawa et al., Gifu, Japan. In Biochem Biophys Res Commun, Jan 2016
In the presence of ced-3 mRNA, CED-4 protein is enriched in the microsomal fraction and interacts with ribosomal protein L10a in mammalian cells, increasing the levels of CED-3.
Transcriptome profiling of sleeping, waking, and sleep deprived adult heterozygous Aldh1L1 - eGFP-L10a mice.
Cirelli et al., Madison, United States. In Genom Data, Dec 2015
We used bacterial artificial chromosome (BAC) transgenic mice expressing eGFP tagged ribosomal protein L10a under the promoter of the Aldh1L1 gene, a highly expressed astrocytic gene.
Mutations in ribosomal proteins, RPL4 and RACK1, suppress the phenotype of a thermospermine-deficient mutant of Arabidopsis thaliana.
Takahashi et al., Okayama, Japan. In Plos One, 2014
Studies of two dominant suppressors of acl5, sac51-d and sac52-d, have revealed that SAC51 and SAC52 encode a transcription factor and a ribosomal protein L10 (RPL10), respectively, and these mutations enhance translation of the SAC51 mRNA, which contains conserved upstream open reading frames in the 5' leader.
Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo.
Humphreys et al., Boston, United States. In Kidney Int, 2014
We expressed enhanced green fluorescent protein-tagged to ribosomal protein L10a in podocytes under the control of the collagen-1α1 promoter, enabling one-step podocyte-specific mRNA isolation over the course of disease.
Monitoring Astrocytic Proteome Dynamics by Cell Type-Specific Protein Labeling.
Dieterich et al., Magdeburg, Germany. In Plos One, 2014
Furthermore, we were able to label astrocytic de novo synthesized proteins and identified both Connexin-43 and 60S ribosomal protein L10a upregulated upon treatment with Brain-derived neurotrophic factor in astrocytes of a neuron-glia coculture.
A retrograde adeno-associated virus for collecting ribosome-bound mRNA from anatomically defined projection neurons.
Reijmers et al., Boston, United States. In Front Mol Neurosci, 2014
We used AAV9 to express Enhanced Green Fluorescent Protein (EGFP)-tagged ribosomal protein L10a (EGFP-L10a), which enables the immunoprecipitation of EGFP-tagged ribosomes and associated mRNA with a method known as Translating Ribosome Affinity Purification (TRAP).
Expression profile of ribosomal protein L10a throughout gonadal development in rainbow trout (Oncorhynchus mykiss).
Chotigeat et al., Thailand. In Fish Physiol Biochem, 2014
Ribosomal protein L10a (RpL10A) has been previously established as a stimulator during the early stages of ovarian development in both the banana prawn and the fruit fly.
A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system.
Reijmers et al., Boston, United States. In Front Mol Neurosci, 2013
Here, we introduce a transgenic mouse model that combines the TRAP technique with the tetracycline transactivator (tTA) system by expressing EGFP-tagged ribosomal protein L10a (EGFP-L10a) under control of the tetracycline response element (tetO-TRAP).
Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.
Girault et al., Paris, France. In Proc Natl Acad Sci U S A, 2013
To address this question we used bacterial artificial chromosome transgenic mice, which express EGFP fused to the N-terminus of the large subunit ribosomal protein L10a driven by the D1 or D2 dopamine receptor (D1R, D2R) promoter, respectively.
Evolutionary implications of intron-exon distribution and the properties and sequences of the RPL10A gene in eukaryotes.
Barreno et al., Madrid, Spain. In Mol Phylogenet Evol, 2013
The RPL10A gene encodes the RPL10 protein, required for joining 40S and 60S subunits into a functional 80S ribosome.
Peripheral blood gene expression analysis in intestinal transplantation: a feasibility study for detecting novel candidate biomarkers of graft rejection.
Ruiz et al., Miami, United States. In Transplantation, 2012
Genes significantly down-regulated in translation related gene sets included ribosomal proteins RPL13A, RP L22, RPS23, RPL13 and RPL10A, that could be used as potential biomarkers for future experiments.
Arabidopsis L10 ribosomal proteins in UV-B responses.
Casati et al., Rosario, Argentina. In Plant Signal Behav, 2010
Ribosomal protein L10 (RPL10) is an ubiquitous protein that participates in joining the 40S and 60S ribosomal subunits into a functional 80S ribosome; however, increasing evidences indicate that RPL10 from various organisms has multiple extra ribosomal functions, besides being a constituent of ribosome and its role in translation.
Plant L10 ribosomal proteins have different roles during development and translation under ultraviolet-B stress.
Casati et al., Rosario, Argentina. In Plant Physiol, 2010
Ribosomal protein L10 (RPL10) proteins are ubiquitous in the plant kingdom.
Evolution of Rhizaria: new insights from phylogenomic analysis of uncultivated protists.
Pawlowski et al., Vancouver, Canada. In Bmc Evol Biol, 2009
Finally, this work reveals another possible rhizarian signature in the 60S ribosomal protein L10a.
A semi-dominant mutation in the ribosomal protein L10 gene suppresses the dwarf phenotype of the acl5 mutant in Arabidopsis thaliana.
Takahashi et al., Okayama, Japan. In Plant J, 2008
SAC52 encodes ribosomal protein L10, a suppressor mutant of acl5-1. Transformation of acl5-1 mutants with a genomic fragment containing the sac52-d allele rescued the dwarf phenotype.
A translational profiling approach for the molecular characterization of CNS cell types.
Heintz et al., New York City, United States. In Cell, 2008
Using bacterial artificial chromosome (BAC) transgenic mice that express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology for affinity purification of polysomal mRNAs from genetically defined cell populations in the brain.
Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL.
Itoh et al., Kurume, Japan. In Tissue Antigens, 2003
two genes coding for ribosomal proteins (S2 and L10a) encoded tumor antigens recognized by HLA-A26-restricted CTLs
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