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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RPD3 Rpd3p

RPD3, HDAC8, Rpd3p, histone deacetylase 8
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Histone, HDAC, CYP3A4, ACID, CAN
Papers using RPD3 antibodies
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases.
Supplier
Skoulakis Efthimios M. C., In PLoS ONE, 2006
... For analysis of the effect of modulation of Rpd3 levels on adult viability, the appropriate transgenic strains and ...
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain
Supplier
Casaccia-Bonnefil Patrizia et al., In The Journal of Cell Biology, 2002
... Santa Cruz Biotechnology, Inc.); HDAC7 (1:100 for IHC, 1:500 for WB; Santa Cruz Biotechnology, Inc.); HDAC8 (1:100 for IHC, 1:500 for WB; Santa Cruz Biotechnology, Inc.); acetylated-lysine (1:1,000 for ...
Papers on RPD3
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model.
New
Artico et al., Padova, Italy. In Autoimmunity, Feb 2016
In particular, selective HDAC3, HDAC6, and HDAC8 inhibitors have been described to downregulate the expression of pro-inflammatory cytokines (TNF-α, TGF-β, IL-1β, and IL-6).
Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro.
New
Chen et al., Shanghai, China. In Acta Pharmacol Sin, Feb 2016
The expression levels of relevant proteins were examined using immunoblotting assays or immunohistochemistry. RESULTS: P-aIgA1 (25-250 μg/mL) dose-dependently promoted the proliferation of HMCs, and markedly increased the protein levels of type I histone deacetylase (HDAC1, HDAC2 and HDAC8) in the cells.
Involvement of rice histone deacetylase HDA705 in seed germination and in response to ABA and abiotic stresses.
New
Duan et al., Guangzhou, China. In Biochem Biophys Res Commun, Feb 2016
In this study, we examined the expression pattern and function of HDA705, a member of the RPD3/HDA1-type HDAC in rice.
NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR.
New
Gerton et al., Kansas City, United States. In Cell Rep, Feb 2016
Mutations in NIPBL, cohesin, and its deacetylase HDAC8 result in Cornelia de Lange syndrome.
Histone deacetylase HDA9 negatively regulates salt and drought stress responsiveness in Arabidopsis.
New
Zhou et al., Wuhan, China. In J Exp Bot, Feb 2016
In this report, we show that the Arabidopsis RPD3-type histone deacetylase HDA9 is involved in modulating plant responses to salt and drought stresses in Arabidopsis.
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation.
New
Impact
Kuo et al., Duarte, United States. In Cell Stem Cell, Dec 2015
Here, we show that p53 activity is inhibited in inv(16)(+) AML LSCs via interactions with the CBFβ-SMMHC (CM) fusion protein and histone deacetylase 8 (HDAC8).
Cornelia de Lange syndrome.
Review
New
Tümer et al., Copenhagen, Denmark. In Clin Genet, Jul 2015
To date five genes [NIPBL (Nipped-B-like protein), SMC1A (structural maintenance of chromosomes 1A), SMC3 (structural maintenance of chromosomes 3), RAD21 (human homolog of Schizosaccharomyces pombe radiation sensitive mutant 21) and HDAC8 (histone deacetylase 8)] have been associated with CdLS and mutations of these genes comprise the underlying defect in 70% of the patients.
HDAC8: a multifaceted target for therapeutic interventions.
Review
New
Jung et al., Freiburg, Germany. In Trends Pharmacol Sci, Jul 2015
Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections.
Renal mechanisms of salt-sensitive hypertension: contribution of two steroid receptor-associated pathways.
Review
New
Fujita et al., Tokyo, Japan. In Am J Physiol Renal Physiol, Apr 2015
β2-Adrenergic stimulation due to increased renal sympathetic activity in obesity- and salt-induced hypertension suppresses histone deacetylase 8 activity via cAMP/PKA signaling, increasing the accessibility of GRs to the negative GR response element in the WNK4 promoter.
Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
Review
Romier et al., Illkirch-Graffenstaden, France. In Future Med Chem, 2014
More precisely, current progress on Schistosoma mansoni HDAC8 (smHDAC8) provided a proof of concept that targeting epigenetic enzymes is a valid approach to treat diseases caused by schistosomes, and possibly other eukaryotic pathogens.
Mysteries of metals in metalloenzymes.
Review
Impact
Alexandrova et al., Los Angeles, United States. In Acc Chem Res, 2014
For example, histone deacetylase 8 naturally operates with Zn(2+) in the active site but becomes much more active with Fe(2+).
Epigenetic therapy of cancer with histone deacetylase inhibitors.
Review
Saldanha et al., Bengaluru, India. In J Cancer Res Ther, 2014
The enzymes Histone Acetyl Transferase (HAT) and Histone Deacetylase (HDAC) control the level of acetylation of histones and thereby alter gene expression.
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Impact
GeneRIF
Shirahige et al., Philadelphia, United States. In Nature, 2012
loss of HDAC8 activity results in increased SMC3 acetylation and inefficient dissolution of the 'used' cohesin complex released from chromatin in both prophase and anaphase
Expression noise and acetylation profiles distinguish HDAC functions.
GeneRIF
Barkai et al., Israel. In Mol Cell, 2012
analysis of distinct activities of the Rpd3(L) and Set3 histone deacetylase complexes
Ume6 transcription factor is part of a signaling cascade that regulates autophagy.
GeneRIF
Klionsky et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
Ume6 is a negative regulator of ATG8 transcription, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels
Exploring the yeast acetylome using functional genomics.
Impact
Andrews et al., Toronto, Canada. In Cell, 2012
A biochemical survey of genes interacting with the KDAC RPD3 identified 72 proteins acetylated in vivo.
Histone deacetylase complexes promote trinucleotide repeat expansions.
GeneRIF
Lahue et al., Galway, Ireland. In Plos Biol, 2012
Mutation or inhibition of yeast Rpd3L or Hda1 suppressed up to 90% of CTG*CAG repeat expansions.
The Rpd3 core complex is a chromatin stabilization module.
GeneRIF
Carey et al., Los Angeles, United States. In Curr Biol, 2012
Rpd3 core complex could contribute to repression via a novel nucleosome stabilization function.
Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.
Impact
Fujita et al., Tokyo, Japan. In Nat Med, 2011
β(2)AR stimulation resulted in cyclic AMP-dependent inhibition of histone deacetylase-8 (HDAC8) activity and increased histone acetylation, leading to binding of the glucocorticoid receptor to a negative glucocorticoid-responsive element in the promoter region.
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