Nuclear signalling by tumour-associated antigen EpCAM.
München, Germany. In Nat Cell Biol, 2009
Released EpICD associates with FHL2, beta-catenin and Lef-1 to form a nuclear complex that contacts DNA at Lef-1 consensus sites, induces gene transcription and is oncogenic in immunodeficient mice.
DNA recognition by beta-sheets.
Tsukuba, Japan. In Biopolymers, 1996
Upon following the major groove a two-stranded antiparallel beta-sheet dives into the groove and contacts DNA bases with its convex side facing the DNA, while upon following the minor groove, it binds around the sugar-phosphate backbones, with its opposite concave side shielding the DNA.
Muscle: the regulation of myogenesis.
Paris, France. In Curr Opin Genet Dev, 1994
At the molecular level, crystallographic studies have led to a structural model of the actinomyosin complex and also to information about how MyoD contacts DNA.
Sequence-specific DNA binding by a short peptide dimer.
Cambridge, United States. In Science, 1990
A recently described class of DNA binding proteins is characterized by the "bZIP" motif, which consists of a basic region that contacts DNA and an adjacent "leucine zipper" that mediates protein dimerization.