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proteins. Page last changed on 19 Dec 2016.
RPB7 Rpb7p
Rpb7, hsRPB7, Rpb7p
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009] (from
NCBI)
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Top mentioned proteins:
POLYMERASE, CAN, Rpb1, RPB2, ACID
Papers on
Rpb7
Modulating the level of the Rpb7 subunit of RNA polymerase II affects cell separation in Schizosaccharomyces pombe.
New Delhi, India. In Res Microbiol, 2015
The rpb7(+) gene encodes the seventh largest subunit of RNA polymerase II and is essential for survival of yeast cells.
The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.
Boston, United States. In Front Oncol, 2011
Beside HIFα, several other VHL targets have been identified, including activated epidermal growth factor receptor (EGFR), RNA polymerase II subunits RPB1 and hsRPB7, atypical protein kinase C (PKC), Sprouty2, β-adrenergic receptor II, and Myb-binding protein p160.
Transcription by the multifunctional RNA polymerase I in Trypanosoma brucei functions independently of RPB7.
Farmington, United States. In Mol Biochem Parasitol, 2011
Instead, a recent report presented evidence that RPB7, the RNA pol II paralog of RPA43, is an RNA pol I subunit and essential for RRNA and VSG transcription in bloodstream form trypanosomes [18].
Human GTPases associate with RNA polymerase II to mediate its nuclear import.
Philadelphia, United States. In Mol Cell Biol, 2011
GPN1 and GPN3 directly interact with RNAPII subunit 7 (RPB7)/RPB4 and the C-terminal domain (CTD) of RNAPII.
mRNA imprinting: Additional level in the regulation of gene expression.
Haifa, Israel. In Cell Logist, 2011
Recently, we have shown that two RNA polymerase II (Pol II) subunits, Rpb4p and Rpb7p, associate with the nascent transcript co-transcriptionally.
Translation by remote control.
Impact
Århus, Denmark. In Cell, 2010
(2010) show that transcriptional imprinting of mRNAs with two subunits of RNA polymerase II, Rbp4p and Rpb7p, guides transcripts to the translation apparatus.
RNA polymerase II subunits link transcription and mRNA decay to translation.
Impact
Haifa, Israel. In Cell, 2010
The yeast proteins Rpb4p and Rpb7p represent one such link as they form a heterodimer that shuttles between the nucleus, where it functions in transcription, and the cytoplasm, where it functions in the major mRNA decay pathways.
The dissociable RPB4 subunit of RNA Pol II has vital functions in Drosophila.
Szeged, Hungary. In Mol Genet Genomics, 2010
RNA polymerase II (Pol II) is composed of a ten subunit core and a two subunit dissociable subcomplex comprising the fourth and seventh largest subunits, RPB4 and RPB7.
In vitro interaction between the N-terminus of the Ewing's sarcoma protein and the subunit of RNA polymerase II hsRPB7.
Sofia, Bulgaria. In Mol Biol Rep, 2009
In vivo and in vitro expressed N-terminal sequence of EWS (EAD) and hsRPB7 (subunit of human RNA polymerase II) were probed for protein-protein interactions using pull-down assays.
RNA pol II subunit RPB7 is required for RNA pol I-mediated transcription in Trypanosoma brucei.
Granada, Spain. In Embo Rep, 2009
In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcribed by RNA polymerase I (pol I) instead of RNA pol II, the polymerase committed to the production of mRNA in eukaryotes.
Mapping RNA exit channel on transcribing RNA polymerase II by FRET analysis.
GeneRIF
Taipei, Taiwan. In Proc Natl Acad Sci U S A, 2009
growing RNA is leading toward Rpb4, not Rpb3, supporting the notion that RNA exits through the proposed pol II RNA exit channel 1
Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex.
GeneRIF
München, Germany. In J Biol Chem, 2008
the complete Pol II associates with DNA in vivo, consistent with functional roles of Rpb4/7 throughout the transcription cycle.
Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes.
GeneRIF
Haifa, Israel. In Genes Dev, 2008
RPB4/RPB7 is a nucleo-cytoplasmic shuttling heterodimer that interacts with Pol II and with mRNAs and is required for mRNA decay in the cytoplasm.
Genomewide recruitment analysis of Rpb4, a subunit of polymerase II in Saccharomyces cerevisiae, reveals its involvement in transcription elongation.
Bengaluru, India. In Eukaryot Cell, 2008
The Rpb4/Rpb7 subcomplex of yeast RNA polymerase II (Pol II) has counterparts in all multisubunit RNA polymerases from archaebacteria to higher eukaryotes.
Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins.
Houston, United States. In Eukaryot Cell, 2008
The core RNAPII subunits RPB5, RPB7, and RPB9 were isolated as potent high-copy-number suppressors of the rtr1Delta temperature-sensitive growth phenotype, and deletion of the nonessential subunits RPB4 and RPB9 hypersensitized cells to RTR1 overexpression.
The Rpb4 subunit of RNA polymerase II contributes to cotranscriptional recruitment of 3' processing factors.
GeneRIF
Boston, United States. In Mol Cell Biol, 2008
Chromatin immunoprecipitation examined the role of the Rpb4/7 heterodimer in transcription in vivo in an rpb4Delta strain for effects on core polymerase & recruitment of other transcription factors. Rpb4/7 cross-links throughout transcribed regions.
The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms.
GeneRIF
Haifa, Israel. In J Cell Biol, 2007
Rpb7p plays pivotal roles in determining mRNA levels.
The RPB7 orthologue E' is required for transcriptional activity of a reconstituted archaeal core enzyme at low temperatures and stimulates open complex formation.
Regensburg, Germany. In J Biol Chem, 2007
RNA polymerases from Archaea and Eukaryotes consist of a core enzyme associated with a dimeric E'F (Rpb7/Rpb4) subcomplex but the functional contribution of the two subunit subcomplexes to the transcription process is poorly understood.
Characterization of the RNA polymerase II and III complexes in Leishmania major.
Seattle, United States. In Int J Parasitol, 2007
identified seven RNAP II subunits: RPB1, RPB2, RPB3, RPB5, RPB7, RPB10 and RPB11.
