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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

RPO21 Rpo21p

Rpb1, RNA polymerase II subunit, RPO21, POLR2A
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, RPB2, CAN, ACID, HAD
Papers using Rpb1 antibodies
p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor
Supplier
Dilworth Francis Jeffrey et al., In The EMBO Journal, 1998
... antibody (Millipore 06-755), Myog (Santa Cruz SC-576), Suz12 (Abcam ab12073), Mef2 (Santa Cruz sc-17785, sc-13917), RPB1 (Abcam ab5408), and Ezh2 (Zymed ...
Papers on Rpb1
Pathogenicity, morphology, and characterization of a Nosema fumiferanae isolate (Microsporidia: Nosematidae) from the light brown apple moth, Epiphyas postvittana (Lepidoptera: Tortricidae) in California.
New
Mills et al., Berkeley, United States. In J Invertebr Pathol, 14 Feb 2016
In addition, we sequenced fragments of commonly used genetic markers (ITS, SSU, and RPB1), and examined the phylogenetic relationships between the Nosema isolate and other microsporidian species commonly found in lepidopteran hosts.
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.
New
Impact
Greenblatt et al., Toronto, Canada. In Nature, 07 Feb 2016
The carboxy-terminal domain (CTD) of the RNA polymerase II (RNAP II) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodelling.
Sexual and asexual states of some endophytic Phialocephala species of Picea.
New
Seifert et al., Ottawa, Canada. In Mycologia, 06 Feb 2016
scopiformis, Ph. piceae and several undescribed species in a clade containing Ph. dimorphospora were collected in the sampling area and characterized by analysis of the nuc internal transcribed spacer rDNA (ITS) and gene for the largest subunit of RNA polymerase II (RPB1) loci.
Five new Pseudophialophora species from grass roots in the oligotrophic pine barrens ecosystem.
New
Zhang et al., New Brunswick, United States. In Fungal Biol, 31 Dec 2015
The five new fungal species are described based on morphological characteristics and DNA sequences of SSU, ITS, LSU, MCM7, RPB1, and TEF1 genes.
Barrenia, a new genus associated with roots of switchgrass and pine in the oligotrophic pine barrens.
New
Zhang et al., New Brunswick, United States. In Fungal Biol, 31 Dec 2015
Phylogenetic analyses based on ITS, LSU, and RPB1 sequence data strongly support that Barrenia is a monophyletic clade in Helotiales, distinct from any known taxa.
Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate.
New
Arcos-Burgos et al., Canberra, Australia. In Mol Psychiatry, 24 Dec 2015
We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes.
Description of a taxonomically undefined Sclerotiniaceae strain from withered rotten-grapes.
New
Zapparoli et al., Verona, Italy. In Antonie Van Leeuwenhoek, 18 Dec 2015
Phylogenetic analysis of partial sequences of glyceraldehyde 3-phosphate dehydrogenase (G3PDH), heat shock protein 60 (HSP60) and DNA-directed RNA polymerase II subunit (RPB2), revealed that strain C10 is distantly related to Amphobotrys and Botrytis.
Two new hyaline-ascospored species of Trichoderma and their phylogenetic positions.
New
Zhuang et al., Beijing, China. In Mycologia, 17 Dec 2015
The phylogenetic positions of the two fungi were investigated based on sequence analyses of RNA polymerase II subunit b and translation elongation factor 1-α genes.
Evidence of genotypic diversity among Candida auris isolates by multilocus sequence typing, matrix-assisted laser desorption ionization time-of-flight mass spectrometry and amplified fragment length polymorphism.
New
Chowdhary et al., Delhi, India. In Clin Microbiol Infect, 05 Dec 2015
RPB1, RPB2 and internal transcribed spacer (ITS) and D1/D2 regions of the ribosomal DNA were sequenced for MLST.
TP53 loss creates therapeutic vulnerability in colorectal cancer.
New
Impact
Lu et al., Houston, United States. In Nature, May 2015
POLR2A is identified as such a gene that is almost always co-deleted with TP53 in human cancers.
Variation in Type A Trichothecene Production and Trichothecene Biosynthetic Genes in Fusarium goolgardi from Natural Ecosystems of Australia.
Liew et al., Sydney, Australia. In Toxins (basel), 2014
In the phylogenies inferred from DNA sequences of genes encoding the RNA polymerase II largest (RPB1) and second largest (RPB2) subunits as well as the trichothecene biosynthetic genes (TRI), F. goolgardi isolates were resolved as a monophyletic clade, distinct from other type A trichothecene-producing species.
Population Genetics of Nosema apis and Nosema ceranae: One Host (Apis mellifera) and Two Different Histories.
Bartolomé et al., Santiago de Compostela, Spain. In Plos One, 2014
Here we analyze the patterns of nucleotide polymorphism at three single-copy loci (PTP2, PTP3 and RPB1) in a collection of Apis mellifera isolates from all over the world, naturally infected either with N. apis (N = 22) or N. ceranae (N = 23), to provide new insights into the genetic diversity, demography and evolution of N. apis, as well as to compare them with evidence from N. ceranae.
The super elongation complex (SEC) family in transcriptional control.
Impact
GeneRIF
Shilatifard et al., Kansas City, United States. In Nat Rev Mol Cell Biol, 2012
Studies indicate that the super elongation complex (SEC) consisting of ELL, P-TEFb (CDK9) and MLL required for rapid transcriptional induction in the presence or absence of paused RNA polymerase II (Pol II).
Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo.
GeneRIF
Lewis et al., Bethesda, United States. In J Biol Chem, 2012
Results indicate roles for both the RNA polymerase II C-terminal domain (CTD) and O-GlcNAc in the regulation of transcription initiation.
Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
GeneRIF
Fisher et al., New York City, United States. In Mol Cell Biol, 2012
Separate domains of Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.
GeneRIF
Eick et al., München, Germany. In Embo J, 2012
Here, the authors report phosphorylation of Thr4 by Polo-like kinase 3 in mammalian cells.
Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.
GeneRIF
Taatjes et al., Boulder, United States. In J Mol Biol, 2012
These results suggest that Mediator structural shifts induced by activator binding help stably orient pol II prior to transcription initiation within the human mediator-RNA polymerase II-TFIIF assembly.
Complementary DNA sequencing: expressed sequence tags and human genome project.
Impact
Moreno et al., Bethesda, United States. In Science, 1991
Of the sequences generated, 337 represent new genes, including 48 with significant similarity to genes from other organisms, such as a yeast RNA polymerase II subunit; Drosophila kinesin, Notch, and Enhancer of split; and a murine tyrosine kinase receptor.
A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases.
Impact
Fink et al., Cambridge, United States. In Cell, 1989
Two of these suppressors, SIT1 and SIT2, are encoded by RPB1 and RPB2, the genes for the two largest subunits of RNA polymerase II.
Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases.
Impact
Ingles et al., In Cell, 1985
We have determined the nucleotide sequence of two yeast RNA polymerase genes, RPO21 and RPO31, which encode the largest subunits of RNA polymerases II and III, respectively.
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