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RPO21 Rpo21p

Rpb1, RNA polymerase II subunit, RPO21, POLR2A
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, RPB2, CAN, ACID, NOV
Papers using Rpb1 antibodies
p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor
Supplier
Dilworth Francis Jeffrey et al., In The EMBO Journal, 1998
... antibody (Millipore 06-755), Myog (Santa Cruz SC-576), Suz12 (Abcam ab12073), Mef2 (Santa Cruz sc-17785, sc-13917), RPB1 (Abcam ab5408), and Ezh2 (Zymed ...
Papers on Rpb1
RNA polymerase II contributes to preventing transcription-mediated replication fork stalls.
New
Aguilera et al., Sevilla, Spain. In Embo J, 01 Jan 2015
Three specific alleles of the RNAPII core, rpb1-1, rpb1-S751F and rpb9∆, cause a defect in replication fork progression, compensated for by additional origin firing, as the main action responsible for instability.
Bioinformatics analysis of gene expression profiles in childhood B-precursor acute lymphoblastic leukemia.
New
Zhu et al., In Hematology, 28 Dec 2014
Besides, total of five modules in INTS10, MCM, BRCA1, GYPA, and VCAN1 families were identified and a pathway of INTS10-INTS6-POLR2A-MAGI2 was selected.
Global diversity of the Ganoderma lucidum complex (Ganodermataceae, Polyporales) inferred from morphology and multilocus phylogeny.
New
Dai et al., Shenyang, China. In Phytochemistry, 25 Nov 2014
The combined dataset, including an outgroup, comprised 33 ITS, 24 tef1α, 24 rpb1 and 21 rpb2 sequences, of which 19 ITS, 20 tef1α, 20 rpb1 and 17 rpb2 sequences were newly generated.
Rpb3 Promotes Hepatocellular Carcinoma through its N-terminus.
New
Han et al., Linhai, China. In Oncotarget, 15 Nov 2014
The expression of RNA polymerase II subunit 3 (Rpb3) was found frequent up-regulation in Hepatocellular carcinoma (HCC) tumors.
The not5 subunit of the ccr4-not complex connects transcription and translation.
New
Collart et al., Genève, Switzerland. In Plos Genet, Oct 2014
This stems from the importance of Not5 for the association of the R2TP Hsp90 co-chaperone with polysomes translating RPB1 mRNA to protect newly synthesized Rpb1 from aggregation.
A genetic assay for transcription errors reveals multilayer control of RNA polymerase II fidelity.
New
Strathern et al., Frederick, United States. In Plos Genet, Sep 2014
We used this Cre-based reporter to screen for mutations of Saccharomyces cerevisiae RPB1 (RPO21) that increase the level of misincorporation during transcription.
Resolving the polyphyletic nature of Pyricularia (Pyriculariaceae).
New
Lebrun et al., Utrecht, Netherlands. In Stud Mycol, Sep 2014
To clarify the taxonomic relationships among species that are magnaporthe- or pyricularia-like in morphology, we analysed phylogenetic relationships among isolates representing a wide range of host plants by using partial DNA sequences of multiple genes such as LSU, ITS, RPB1, actin and calmodulin.
Identification of optimal reference genes for gene expression normalization in a wide cohort of endometrioid endometrial carcinoma tissues.
New
Bignotti et al., Brescia, Italy. In Plos One, Dec 2013
In this study, 10 normalization genes (GAPDH, B2M, ACTB, POLR2A, UBC, PPIA, HPRT1, GUSB, TBP, H3F3A) belonging to different functional and abundance classes in various tissues and used in different studies, were analyzed to determine their applicability.
The super elongation complex (SEC) family in transcriptional control.
Impact
GeneRIF
Shilatifard et al., Kansas City, United States. In Nat Rev Mol Cell Biol, 2012
Studies indicate that the super elongation complex (SEC) consisting of ELL, P-TEFb (CDK9) and MLL required for rapid transcriptional induction in the presence or absence of paused RNA polymerase II (Pol II).
Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo.
GeneRIF
Lewis et al., Bethesda, United States. In J Biol Chem, 2012
Results indicate roles for both the RNA polymerase II C-terminal domain (CTD) and O-GlcNAc in the regulation of transcription initiation.
Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
GeneRIF
Fisher et al., New York City, United States. In Mol Cell Biol, 2012
Separate domains of Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.
GeneRIF
Eick et al., München, Germany. In Embo J, 2012
Here, the authors report phosphorylation of Thr4 by Polo-like kinase 3 in mammalian cells.
Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.
GeneRIF
Taatjes et al., Boulder, United States. In J Mol Biol, 2012
These results suggest that Mediator structural shifts induced by activator binding help stably orient pol II prior to transcription initiation within the human mediator-RNA polymerase II-TFIIF assembly.
A phylogenetic overview of the Agaricomycotina.
Review
Hibbett, Worcester, United States. In Mycologia, 2006
Recent phylogenetic analyses by P. Matheny and colleagues combining nuclear rRNA genes with the protein-coding genes rpb1, rpb2 and tef1 support the division of Agaricomycotina into Tremellomycetes, Dacrymycetes and Agaricomycetes.
Evolutionary relationships among basal fungi (Chytridiomycota and Zygomycota): Insights from molecular phylogenetics.
Review
Sugiyama et al., Ibaraki, Japan. In J Gen Appl Microbiol, 2005
Evolutionary relationships of the two basal fungal phyla Chytridiomycota and Zygomycota are reviewed in light of recent molecular phylogenetic investigation based on rDNA (nSSU, nLSU rDNA), entire mitochondrial genomes, and nuclear protein coding gene sequences (e.g., EF-1alpha, RPB1).
CTD phosphatase: role in RNA polymerase II cycling and the regulation of transcript elongation.
Review
Dahmus et al., In Prog Nucleic Acid Res Mol Biol, 2001
The repetitive C-terminal domain (CTD) of the largest RNA polymerase II subunit plays a critical role in the regulation of gene expression.
Complementary DNA sequencing: expressed sequence tags and human genome project.
Impact
Moreno et al., Bethesda, United States. In Science, 1991
Of the sequences generated, 337 represent new genes, including 48 with significant similarity to genes from other organisms, such as a yeast RNA polymerase II subunit; Drosophila kinesin, Notch, and Enhancer of split; and a murine tyrosine kinase receptor.
RNA polymerase II: subunit structure and function.
Review
Young et al., Cambridge, United States. In Trends Biochem Sci, 1990
Epitope tagging and other experiments made possible by the cloning of these genes have provided a clearer picture of RNA polymerase II subunit composition, stoichiometry and function, and set the stage for further investigating the dialogue between RNA polymerase II and transcription factors.
A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases.
Impact
Fink et al., Cambridge, United States. In Cell, 1989
Two of these suppressors, SIT1 and SIT2, are encoded by RPB1 and RPB2, the genes for the two largest subunits of RNA polymerase II.
Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases.
Impact
Ingles et al., In Cell, 1985
We have determined the nucleotide sequence of two yeast RNA polymerase genes, RPO21 and RPO31, which encode the largest subunits of RNA polymerases II and III, respectively.
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