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RNA polymerase II associated protein 3

RPAP3, RNA polymerase II-associated protein 3
This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009] (from NCBI)
Papers on RPAP3
RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway.
Kamisaki et al., Suita, Japan. In Biochem Biophys Res Commun, 2011
These results indicate that RPAP3 may be a novel modulator of NF-kappaB pathway in apoptosis induced by anti-cancer chemotherapeutic agents.
HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II.
Bertrand et al., Dundee, United Kingdom. In Mol Cell, 2010
Data indicate that RNA polymerase II is built in the cytoplasm and reveal quality-control mechanisms that link HSP90 and its cochaperone hSpagh (RPAP3) to the nuclear import of fully assembled enzymes.
High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
Coulombe et al., Montréal, Canada. In Methods, 2009
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage.
Kamisaki et al., Suita, Japan. In J Cell Biochem, 2009
RPAP3 interacts with Reptin to modulate UV-induced DNA damage by regulating H2AX phosphorylation
Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains.
Kamisaki et al., Suita, Japan. In Febs Lett, 2008
Overexpression of RPAP3 in HEK 293 cells potentiated caspase-3 activation and apoptosis.
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