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Replication protein A4, 30kDa

This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010] (from NCBI)
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Papers on RpA4
An alternative form of replication protein a expressed in normal human tissues supports DNA repair.
Wold et al., Chapel Hill, United States. In J Biol Chem, 2010
Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells.
A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.
Wold et al., Iowa City, United States. In Nucleic Acids Res, 2010
Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell.
Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage.
Zou et al., Johnson City, United States. In Biochem J, 2005
Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage.
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