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Replication protein A4, 30kDa

This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010] (from NCBI)
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Top mentioned proteins: RPA2, POLYMERASE, RPA, CAN, OUT
Papers on RpA4
Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas.
Melin et al., Uppsala, Sweden. In J Neurooncol, 2011
In this dataset, eight gene variants mapping to five different DNA repair genes (ATM, NEIL1, NEIL2, ERCC6 and RPA4) which were associated with survival.
Functions of alternative replication protein A in initiation and elongation.
Wold et al., Iowa City, United States. In Biochemistry, 2010
aRPA is composed of three subunits: RPA1 and RPA3, also present in canonical RPA, and a primate-specific subunit RPA4, homologous to canonical RPA2.
An alternative form of replication protein a expressed in normal human tissues supports DNA repair.
Wold et al., Chapel Hill, United States. In J Biol Chem, 2010
Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells.
A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.
Wold et al., Iowa City, United States. In Nucleic Acids Res, 2010
Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell.
Eukaryotic single-stranded DNA binding proteins: central factors in genome stability.
Nasheuer et al., Galway, Ireland. In Subcell Biochem, 2009
Recently a human homologue to the RPA2 subunit, called RPA4, was discovered and RPA4 can substitute for RPA2 in the RPA complex resulting in an "alternative" RPA (aRPA), which can bind to ssDNA with similar affinity as canonical RPA.
Typhus and other rickettsioses: emerging infections in Germany.
Wölfel et al., München, Germany. In Dtsch Arztebl Int, 2009
RpA4, has not yet been associated with any human disease.
An alternative form of replication protein a prevents viral replication in vitro.
Wold et al., Iowa City, United States. In J Biol Chem, 2009
The "canonical" RPA is composed of three subunits (RPA1, RPA2, and RPA3); however, there is a human homolog to the RPA2 subunit, called RPA4, that can substitute for RPA2 in complex formation.
Prevalence of tick-borne zoonotic bacteria in questing adult ticks from northern Spain.
García-Pérez et al., Spain. In Vector Borne Zoonotic Dis, 2008
RpA4/DnS14 by sequencing of the citrate synthase (gltA) gene.
Rickettsia sp. strain RpA4 detected in Portuguese Dermacentor marginatus ticks.
Zé-Zé et al., Lisbon, Portugal. In Vector Borne Zoonotic Dis, 2006
Recently, a new rickettsia genotype, RpA4, was detected in several Dermacentor sp.
The role of wild boar (Sus scrofa) in the eco-epidemiology of R. slovaca in Northeastern Spain.
Segura-Porta et al., Barcelona, Spain. In Vector Borne Zoonotic Dis, 2006
RpA4 was identified in 4 specimens of D. marginatus removed from wild boar.
Ticks and associated pathogens collected from domestic animals in the Netherlands.
Jongejan et al., Utrecht, Netherlands. In Vector Borne Zoonotic Dis, 2006
DnS14/RpA4 (14.0%), and Borrelia burgdorferi sensu lato (0.3%) were detected in the D. reticulatus ticks, which appeared to be free from B. canis infection.
Prevalence data of Rickettsia slovaca and other SFG Rickettsiae species in Dermacentor marginatus in the southeastern Iberian peninsula.
Muniain et al., Jaén, Spain. In Ann N Y Acad Sci, 2006
SFG rickettsia has been detected in 85.15% of ticks studied (26.7% of positives have been to R. slovaca, the causative agent of TIBOLA-DEBONEL, and 73.3% to SFG rickettsia closely related to strains RpA4-JL-02-DnS14-DnS28).
Prevalence of spotted fever group Rickettsia species detected in ticks in La Rioja, Spain.
Sanz et al., Logroño, Spain. In Ann N Y Acad Sci, 2006
strains RpA4, DnS14, DnS28 and JL-02 (59.3%) were found within this tick species.
Spotted fever group rickettsiae in ticks feeding on humans in northwestern Spain: is Rickettsia conorii vanishing?
Encinas-Grandes et al., Salamanca, Spain. In Ann N Y Acad Sci, 2006
RpA4/DnS14, R. helvetica, Rickettsia sp.
Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage.
Zou et al., Johnson City, United States. In Biochem J, 2005
Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage.
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