hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes.
Tampa, United States. In Oncogene, Oct 2015
It not only senses DNA damage, binds double-stranded DNA in a sequence-independent manner, facilitates processing of damaged DNA, promotes DNA end joining, regulates replication protein A (RPA2) phosphorylation and ubiquitination at damaged DNA, but also regulates RNA splicing and mitotic spindle formation in its integral capacity as a scaffold for a multimeric core complex.
Replication, repair, and reactivation.
New York City, United States. In Dev Cell, 2005
In a recent issue of Current Biology, Kapoor et al. (2005) and Elmayan et al. (2005) illuminate the linkage between DNA replication and repair and transcriptional gene silencing in plants by showing that mutants in RPA2, a homolog of yeast and mammalian replication protein A, exhibit loss of silencing at transgene loci as well as some transposable elements.
Molecular pathology of the MEN1 gene.
Bethesda, United States. In Ann N Y Acad Sci, 2004
It may partner with junD, NF-kB, PEM, SMAD3, RPA2, FANCD2, NM23beta, nonmuscle myosin heavy chain II-A, GFAP, and/or vimentin.