Chromosome position determines the success of double-strand break repair.
Waltham, United States. In Proc Natl Acad Sci U S A, Feb 2016
The repair efficiency of a donor locus can be improved by four factors: slower 5' to 3' resection of the DSB ends, increased abundance of replication protein factor A (RPA), longer shared homology, or presence of a recombination enhancer element adjacent to a donor.
HELB Is a Feedback Inhibitor of DNA End Resection.
Toronto, Canada. In Mol Cell, Feb 2016
HELB is recruited to ssDNA by interacting with RPA and uses its 5'-3' ssDNA translocase activity to inhibit EXO1 and BLM-DNA2, the nucleases catalyzing resection.
hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes.
Tampa, United States. In Oncogene, Oct 2015
It not only senses DNA damage, binds double-stranded DNA in a sequence-independent manner, facilitates processing of damaged DNA, promotes DNA end joining, regulates replication protein A (RPA2) phosphorylation and ubiquitination at damaged DNA, but also regulates RNA splicing and mitotic spindle formation in its integral capacity as a scaffold for a multimeric core complex.
Telomere elongation chooses TERRA ALTernatives.
Zürich, Switzerland. In Rna Biol, 2014
TERRA and telomeric hybrids act in concert with a number of other factors, including the RNA endoribonuclease RNaseH1 and the single stranded DNA binding protein RPA.