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Replication protein A1, 70kDa

RPA, Replication Protein A
A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes. (from NCBI)
Top mentioned proteins: CAN, Rad51, POLYMERASE, V1a, Chk1
Papers using RPA antibodies
Xenopus CENP-A assembly into chromatin requires base excision repair proteins
Supplier
Slupphaug Geir et al., In The EMBO Journal, 2004
... Primary antibodies were PU059 recognising the catalytic domain of UNG2 (0.5 μg/ml), anti-RPA (Abcam ab2175), anti-PCNA (Abcam ab29), ...
Blockade of Attachment and Fusion Receptors Inhibits HIV-1 Infection of Human Cervical Tissue
Supplier
Shattock Robin J. et al., In The Journal of Experimental Medicine, 2001
... HIV-1 inhibitors used included mAbs: anti-CD4 (clone RPA-T4; BD Biosciences), anti-MR (clone19.2;
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
Supplier
Young John A. T, In PLoS Pathogens, 2000
... purity was examined by flow cytometry with the same ab and an allophycocyanin-conjugated anti-CD4 (clone RPA-T4, BD Biosciences).
Characterization and application of a thermostable primary transport system: cytochrome-C oxidase from Bacillus stearothermophilus.
Supplier
Schwartz Olivier, In PLoS ONE, 1988
... PE-labeled anti-human CCR5, clone 2D7; PE-labeled anti-human CXCR4, clone 12G5; and PE-labeled anti-human CD4, clone RPA-T4 were purchased from BD Biosciences Pharmingen (San Jose, CA) ...
Papers on RPA
Chromosome position determines the success of double-strand break repair.
New
Haber et al., Waltham, United States. In Proc Natl Acad Sci U S A, Feb 2016
The repair efficiency of a donor locus can be improved by four factors: slower 5' to 3' resection of the DSB ends, increased abundance of replication protein factor A (RPA), longer shared homology, or presence of a recombination enhancer element adjacent to a donor.
Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.
New
Fesik et al., Nashville, United States. In Chemmedchem, Feb 2016
UNASSIGNED: Replication protein A (RPA) is an essential single-stranded DNA (ssDNA)-binding protein that initiates the DNA damage response pathway through protein-protein interactions (PPIs) mediated by its 70N domain.
HELB Is a Feedback Inhibitor of DNA End Resection.
New
Durocher et al., Toronto, Canada. In Mol Cell, Feb 2016
HELB is recruited to ssDNA by interacting with RPA and uses its 5'-3' ssDNA translocase activity to inhibit EXO1 and BLM-DNA2, the nucleases catalyzing resection.
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.
New
Bohr et al., Baltimore, United States. In Dna Repair (amst), Jan 2016
Additionally, we investigate how different known RecQ interacting proteins, RPA, Ku, FEN1 and RAD51, regulate their strand annealing activity.
RPA homologs and ssDNA processing during meiotic recombination.
Review
New
Martini et al., Fontenay-aux-Roses, France. In Chromosoma, Dec 2015
Replication protein A (RPA) is the main ssDNA-binding protein complex involved in DNA metabolism.
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
New
Impact
Feigon et al., Los Angeles, United States. In Science, Nov 2015
In addition to seven known holoenzyme proteins, we identify two additional proteins that form a complex (TEB) with single-stranded telomere DNA-binding protein Teb1, paralogous to heterotrimeric replication protein A (RPA).
The ERCC1 and ERCC4 (XPF) genes and gene products.
Review
New
Wood et al., United States. In Gene, Oct 2015
ERCC1-XPF interacts with other proteins including XPA, RPA, SLX4 and TRF2 to perform its functions.
hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes.
Review
New
Mahajan, Tampa, United States. In Oncogene, Oct 2015
It not only senses DNA damage, binds double-stranded DNA in a sequence-independent manner, facilitates processing of damaged DNA, promotes DNA end joining, regulates replication protein A (RPA2) phosphorylation and ubiquitination at damaged DNA, but also regulates RNA splicing and mitotic spindle formation in its integral capacity as a scaffold for a multimeric core complex.
Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.
Review
New
Chazin et al., Nashville, United States. In Prog Biophys Mol Biol, Mar 2015
Here, we introduce a number of key characteristics and concepts, including the modularity of the proteins, linkage of weak binding sites, direct competition between sites, and allostery, using the well recognized hub protein replication protein A (RPA).
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
New
Impact
Zou et al., United States. In Science, Feb 2015
Here, we show that ATRX loss compromises cell-cycle regulation of the telomeric noncoding RNA TERRA and leads to persistent association of replication protein A (RPA) with telomeres after DNA replication, creating a recombinogenic nucleoprotein structure.
Telomere elongation chooses TERRA ALTernatives.
Review
Azzalin et al., Zürich, Switzerland. In Rna Biol, 2014
TERRA and telomeric hybrids act in concert with a number of other factors, including the RNA endoribonuclease RNaseH1 and the single stranded DNA binding protein RPA.
Selecting key genes associated with osteosarcoma based on a differential expression network.
Jia et al., Jinan, China. In Genet Mol Res, 2014
Six hub genes (APP, UBC, CAND1, RPA, YWHAG, and NEDD8) were discovered; of these, two genes (UBC and RPA) were also found to be disease genes.
ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
Impact
Lukas et al., Copenhagen, Denmark. In Cell, 2013
Although initially stable, stalled forks in ATR-deficient cells undergo nucleus-wide breakage after unscheduled origin firing generates an excess of single-stranded DNA that exhausts the nuclear pool of RPA.
Naked replication forks break apRPArt.
Impact
Nussenzweig et al., Madrid, Spain. In Cell, 2013
(2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted.
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Impact
Casellas et al., Bethesda, United States. In Nature, 2012
Conversely, translocations associated with recurrent site-directed DNA damage are proportional to the rate of DNA break formation, as measured by replication protein A accumulation at the site of damage.
Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress.
GeneRIF
Fanning et al., Nashville, United States. In J Biol Chem, 2012
Replication stress-induced recruitment of HDHB to chromatin is independent of checkpoint signaling but correlates with the level of replication protein A (RPA) recruited to chromatin.
Repair-specific functions of replication protein A.
GeneRIF
Wold et al., Iowa City, United States. In J Biol Chem, 2012
cells require different RPA functions in DNA replication and DNA repair.
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
GeneRIF
Fukushima et al., Sapporo, Japan. In J Radiat Res (tokyo), 2011
The radiosensitizing effect of DPYD depletion plus CPT was the additive effect of DPYD depletion and CPT.
Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndrome.
GeneRIF
O'Driscoll et al., Brighton, United Kingdom. In Plos Genet, 2011
these data identifies unanticipated defects in the DNA damage response associated with duplications in 17p13.3 in humans involving modest RPA1 over-expression.
Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA.
GeneRIF
Pavlov et al., Omaha, United States. In Plos One, 2010
Study propose that RPA plays a role in the protection of the human genome cell from A3G and other deaminases when they are inadvertently diverged from their natural targets.
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