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DCN1, defective in cullin neddylation 1, domain containing 1

RP42, DCUN1D1, KLHL7, Squamous cell carcinoma-related oncogene, Dcn1-like protein
This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: Cullin, Ubiquitin, Derlin-2, OUT, CAN
Papers on RP42
A genome-wide association study of chronic obstructive pulmonary disease in Hispanics.
Celedón et al., Pittsburgh, United States. In Ann Am Thorac Soc, Mar 2015
The first (rs858249, combined P value = 6.1 × 10(-8)) is near the genes KLHL7 and NUPL2 on chromosome 7.
Osteosarcoma tissues and cell lines from patients with differing serum alkaline phosphatase concentrations display minimal differences in gene expression patterns.
Stein et al., Madison, United States. In Vet Comp Oncol, Mar 2015
Using a more sensitive empirical Bayes procedure, defective in cullin neddylation 1 domain containing 1 (DCUN1D1) was increased in both the tissue and cell lines of the normal ALP group.
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
Singh et al., New York City, United States. In J Biol Chem, Feb 2015
Amplification of squamous cell carcinoma-related oncogene (SCCRO) activates its function as an oncogene in a wide range of human cancers.
SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).
Singh et al., New York City, United States. In J Biol Chem, 2015
As a component of the E3 for neddylation, SCCRO/DCUN1D1 plays a key regulatory role in neddylation and, consequently, cullin-RING ligase activity.
New COL6A6 variant detected by whole-exome sequencing is linked to break points in intron 4 and 3'-UTR, deleting exon 5 of RHO, and causing adRP.
Carballo et al., Barcelona, Spain. In Mol Vis, 2014
We used a newly devised multiplex PCR assay capable of amplifying the genetic loci of RHO, PRPH2, RP1, PRPF3, PRPF8, PRPF31, IMPDH1, NRL, CRX, KLHL7, and NR2E3 to molecularly diagnose 18 index patients with adRP.
Matrilin-3 as a putative effector of C-type natriuretic peptide signaling during TGF-β induced chondrogenic differentiation of mesenchymal stem cells.
Tufan et al., Edmonton, Canada. In Mol Biol Rep, 2014
The up-regulated genes included matrilin-3 (MATN3), engulfment and cell motility 1 (ELMO1), CD24, and DCN1, defective in cullin neddylation 1, domain containing 1 (DCUN1D1).
Label-free, real-time detection of the dynamic processes of protein degradation using oblique-incidence reflectivity difference method.
Zhu et al., Beijing, China. In Appl Phys Lett, 2014
Based on the requirements for studying the dynamic process of proteinase action substrates in life science, we selected six random proteins including 1L-10, SCGB2A2, CENPQ, GST, HK1, KLHL7, as well as five different concentrations of 1L-10 proteins of 1 mg/ml, 0.5 mg/ml, 0.25 mg/ml, 0.125 mg/ml, and 0.0625 mg/ml, and fabricated two types of substrate protein microarrays, respectively.
Identification of druggable cancer driver genes amplified across TCGA datasets.
Kouros-Mehr et al., Indianapolis, United States. In Plos One, 2013
The ubiquitin-like ligase DCUN1D1 and the histone methyltransferase NSD3 were also identified as novel putative cancer driver genes.
Coamplification and cooperation: toward identifying biologically relevant oncogenes.
Singh et al., New York City, United States. In Clin Cancer Res, 2013
Assessing for coactivation of functionally related genes resulted in the identification of SENP2, DCUN1D1, and DVL3--consensus candidates that drive selection for 3q amplification in lung squamous cell carcinomas.
Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung.
Massion et al., Nashville, United States. In Clin Cancer Res, 2013
RESULTS: The meta-analysis identified 20 consensus candidates, among which four (SENP2, DCUN1D1, DVL3, and UBXN7) are involved in a small protein-protein interaction network.
Prevalence of mutations in eyeGENE probands with a diagnosis of autosomal dominant retinitis pigmentosa.
Daiger et al., Houston, United States. In Invest Ophthalmol Vis Sci, 2013
The 10 most common genes causing adRP (IMPDH1, KLHL7, NR2E3, PRPF3/RP18, PRPF31/RP11, PRPF8/RP13, PRPH2/RDS, RHO, RP1, and TOPORS) were chosen for PCR-based dideoxy sequencing, along with the two X-linked RP genes, RPGR and RP2.
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Bullock et al., Oxford, United Kingdom. In J Biol Chem, 2013
To define the molecular basis for this assembly and the overall architecture of the E3, we determined the crystal structures of the BTB-BACK domains of KLHL11 both alone and in complex with Cul3, along with the Kelch domain structures of KLHL2 (Mayven), KLHL7, KLHL12, and KBTBD5.
Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry.
Parra et al., Toronto, Canada. In Bmc Evol Biol, 2012
Of these, eight genes (ATRN, EDAR, KLHL7, MITF, OCA2, TH, TMEM33 and TRPM1,) were extreme outliers (top 0.1% of the empirical distribution) for at least one statistic, and twelve genes (ADAM17, BNC2, CTSD, DCT, EGFR, LYST, MC1R, MLPH, OPRM1, PDIA6, PMEL (SILV) and TYRP1) were in the top 1% of the empirical distribution for at least one statistic.
Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma.
Kojima et al., Tokyo, Japan. In Plos One, 2012
3q25-qter including CCNL1, TP63, DCUN1D1 and PIK3CA (q=0.014), and CSMD1 (q=0.019).
Phenotypic characterization of 3 families with autosomal dominant retinitis pigmentosa due to mutations in KLHL7.
Hughbanks-Wheaton et al., Dallas, United States. In Arch Ophthalmol, 2011
The phenotypes are similar among patients with 3 types of KLHL7 mutations (c.458C>T, c.449G>A, and c.457G>A).
Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1.
Pan et al., New York City, United States. In J Biol Chem, 2011
a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.
Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation.
Chiba et al., Tsukuba, Japan. In J Biol Chem, 2011
KLHL7 forms a dimer, assembles with Cul3 through its BTB and BACK domains, and exerts E3 activity.
SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex.
Singh et al., New York City, United States. In J Biol Chem, 2011
in the nucleus, SCCRO enhances recruitment of Ubc12 to Cul1 to promote neddylation
SCCRO promotes glioma formation and malignant progression in mice.
Singh et al., New York City, United States. In Neoplasia, 2010
SCCRO promotes glioma formation and malignant progression.
SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma.
Singh et al., New York City, United States. In Ann Thorac Surg, 2004
BACKGROUND: Overexpression of squamous cell carcinoma-related oncogene (SCCRO) is associated with invasive progression and poor outcomes in non-small cell lung cancer.
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