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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAR-related orphan receptor B

RORbeta, RZR beta, RORB
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, Staggerer, CLOCK, RORalpha
Papers on RORbeta
Melatonin replacement restores the circadian behavior in adult rat Leydig cells after pinealectomy.
New
Kostic et al., Novi Sad, Serbia. In Mol Cell Endocrinol, Oct 2015
Data revealed 24-h-rhythmic expression of clock genes (Bmal1, Per1,2,3, Rev-erba,b, Rorb), steroidogenic genes (Star, Cyp11a1, Cyp17a1), and genes of steroidogenic regulators (positive-Nur77, negative-Arr19).
[Circadian markers and genes in bipolar disorder].
New
Belliviera et al., Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies.
New
Sander et al., Köln, Germany. In Plos Genet, May 2015
Microdeletions found only in GGE patients harboured a high proportion of genes previously associated with epilepsy and neuropsychiatric disorders (NRXN1, RBFOX1, PCDH7, KCNA2, EPM2A, RORB, PLCB1).
RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: a case-control study in Malaysia.
New
Mohamed et al., Kuala Lumpur, Malaysia. In Genomics, Apr 2015
RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock.
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.
Perry et al., Cambridge, United States. In Nat Commun, 2014
Newly implicated genes include two retinoic acid-related receptors, RORB and RXRA, and two genes reportedly disrupted in rare disorders of puberty, LEPR and KAL1.
Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder.
Kuo et al., Taipei, Taiwan. In Plos One, 2014
The current study aimed to investigate the relationships between genetic variants in NR1D1 RORA, and RORB genes and BD in the Han Chinese population.
Genetic association study of circadian genes with seasonal pattern in bipolar disorders.
Etain et al., Paris, France. In Sci Rep, 2014
A SP in BD was nominally associated with 14 SNPs identified in 6 circadian genes: NPAS2, CRY2, ARNTL, ARNTL2, RORA and RORB.
Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.
Forrest et al., Bethesda, United States. In J Biol Chem, 2014
We have reported previously that the retinoid-related orphan receptor β gene (Rorb) is required for Nrl expression and other retinal functions.
The expression of MTNR3 and nuclear receptors in murine leucocytes.
Girkontaite et al., Vilnius, Lithuania. In In Vivo, 2014
Rorb was not detected in lymphocytes.
Gene expression signatures of primary and metastatic uterine leiomyosarcoma.
Wang et al., Oslo, Norway. In Hum Pathol, 2014
Genes overexpressed in primary uterine LMSs included OSTN, NLGN4X, NLGN1, SLITRK4, MASP1, XRN2, ASS1, RORB, HRASLS, and TSPAN7.
[The pathophysiological roles and regulatory mechanism of retinoic acid receptor-related orphan receptors].
Review
He et al., Shanghai, China. In Sheng Li Ke Xue Jin Zhan, 2013
RORs subfamily consists of three members: RORalpha, RORbeta, and RORgamma.
Clock gene variants in mood and anxiety disorders.
Review
Partonen, Helsinki, Finland. In J Neural Transm, 2012
The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Review
Impact
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics.
Review
Burris et al., Jupiter, United States. In Curr Opin Lipidol, 2010
RECENT FINDINGS: Significant progress was made in the initial identification of ligands for the RORs when X-ray crystallographic studies identified several molecules within the ligand-binding pockets of RORalpha and RORbeta.
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.
Review
Jetten, United States. In Nucl Recept Signal, 2008
These studies revealed that RORalpha plays a critical role in the development of the cerebellum, that both RORalpha and RORbeta are required for the maturation of photoreceptors in the retina, and that RORgamma is essential for the development of several secondary lymphoid tissues, including lymph nodes.
Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus.
GeneRIF
Okamura et al., Kōbe, Japan. In Neurosci Lett, 2002
In the suprachiasmatic nucleus, ROR beta mRNA signals showed a peak at early daytime and a trough at early nighttime. ROR beta is a transcription factor possibly related to the circadian pacemaking system.
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