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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Macrophage stimulating 1 receptor

Ron, STK, Fv-2
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: MSP, CAN, hepatocyte growth factor, V1a, HAD
Papers using Ron antibodies
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Supplier
Waltz Susan E. et al., In Oncogene, 2005
... Antibodies for Western analyses included anti-Ron β (C-20) (Santa Cruz Biotechnology, Santa Cruz, CA), anti-β-catenin ...
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Supplier
Hayman M.J. et al., In Oncogene, 2005
... anti-phospho-MAPK and anti-FAK from BD Transduction Laboratories (San Diego, CA, USA), anti-RON (sc-22) and all anti-phospho-RON rabbit polyclonal antibodies were from Santa Cruz Biotechnology, Inc ...
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.
Supplier
Sussman Joel L., In PLoS ONE, 1988
... RON protein, secreted into the conditioned serum free media (HyClone SFX), was detected by Western analysis using the C-terminal specific Penta-His monoclonal Antibody (Qiagen).
Papers on Ron
Novel splicing variants of recepteur d'origine nantais (RON) tyrosine kinase involving exons 15-19 in lung cancer.
New
Al-Daghri et al., Riyadh, Saudi Arabia. In Lung Cancer, Feb 2016
RON is a single pass transmembrane receptor tyrosine kinase (RTK) shown to be aberrantly expressed in various cancer types.
Differences in GFR and Tissue Oxygenation, and Interactions between Stenotic and Contralateral Kidneys in Unilateral Atherosclerotic Renovascular Disease.
New
Textor et al., Rochester, United States. In Clin J Am Soc Nephrol, Feb 2016
RESULTS: Total GFR did not change over 3 months in either group, but the stenotic kidney (STK) GFR rose over time in the stent compared with the medical group (+2.2[-1.8 to 10.5] versus -5.3[-7.3 to -0.3] ml/min; P=0.03).
RON nuclear translocation under hypoxia potentiated chemoresistance to DNA double-strand break-inducing anti-cancer drugs.
New
Chow et al., Zhengzhou, China. In Mol Cancer Ther, Feb 2016
RON (aka macrophage-stimulating protein receptor [MST1R]) belongs to the c-MET (aka hepatocyte growth factor receptor [HGFR]) receptor tyrosine kinase (RTK) superfamily.
The role of STK 11 gene testing in individuals with oral pigmentation.
New
Winship et al., Melbourne, Australia. In Australas J Dermatol, Feb 2016
STK 11 gene testing allows clinicians to differentiate between these two disorders.
The linker between LOV2-Jα and STK plays an essential role in the kinase activation by blue light in Arabidopsis phototropin1, a plant blue light receptor.
New
Tokutomi et al., Sakai, Japan. In Febs Lett, Jan 2016
Phototropin (phot), a blue light receptor in plants, is composed of several domains: LOV1, LOV2, and a serine/threonine kinase (STK).
Recepteur d'origine nantais (RON), more than a kinase: Role in castrate-resistant prostate cancer.
Review
New
Kumar et al., San Antonio, United States. In Mol Carcinog, Oct 2015
We primarily focus on the emerging dual function of the receptor tyrosine kinase (recepteur d'origine nantais; RON) as a traditional tyrosine kinase and transcription factor.
Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets.
Review
New
Freeman et al., San Antonio, United States. In Oncotarget, Mar 2015
c-Met and receptor originated from nantes (RON) are structurally related transmembrane phosphotyrosine kinase receptors.
MSP: an emerging player in metabolic syndrome.
Review
New
Neumann et al., Maastricht, Netherlands. In Cytokine Growth Factor Rev, Feb 2015
MSP (Macrophage Stimulating Protein; also known as Hepatocyte Growth Factor-like protein (HGFL) and MST1) is a secreted protein and the ligand for transmembrane receptor tyrosine kinase Recepteur d'Origine Nantais (RON; also known as MST1R).
Nuclear receptors in pancreatic tumor cells.
Review
Kouraklis et al., Athens, Greece. In Anticancer Res, 2014
RESULTS: Receptors of growth factors, such as the epithelial growth factor receptor, insulin-like growth factor-1 receptor, vascular endothelial growth factor receptor and others, such as integrin α5β1, somatostatin receptors, the death receptor 5, claudin, notch receptors, mesothelin receptors, follicle-stimulating hormone receptors, the MUC1 receptor, the adrenomedullin receptor, the farnesoid X receptor, the transferrin receptor, sigma-2 receptors, the chemokine receptor CXCR4, the urokinase plasminogen activator receptor, the ephrine A2 receptor, the GRIA3 receptor, the RON receptor and the angiotensin II receptor AT-1 are expressed in pancreatic tumor cells.
Regulation of Macrophage Polarization by RON Receptor Tyrosine Kinase Signaling.
Review
Chaudhuri, San Francisco, United States. In Front Immunol, 2013
In this perspective, I discuss the function of recepteur d'origine nantais (RON) receptor tyrosine kinase in regulating the M2-like state of macrophage activation Besides decreasing pro-inflammatory cytokine production in response to toll-like receptor-4 activation, macrophage-stimulating protein strongly suppresses nitric oxide synthase and at the same time upregulates arginase, which is the rate limiting enzyme in the ornithine biosynthesis pathway.
The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK.
Impact
Martienssen et al., Kuala Selangor, Malaysia. In Nature, 2013
Using homozygosity mapping by sequencing, we found two independent mutations in the DNA-binding domain of a homologue of the MADS-box gene SEEDSTICK (STK, also known as AGAMOUS-LIKE 11), which controls ovule identity and seed development in Arabidopsis.
MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Review
Impact
Wang et al., Hangzhou, China. In Nat Rev Cancer, 2013
Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON (also known as MST1R) in the early 1990s, the roles of this signalling axis in cancer pathogenesis has been extensively studied in various model systems.
Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.
Impact
Srinivasan et al., Boston, United States. In J Clin Oncol, 2013
PURPOSE: Foretinib is an oral multikinase inhibitor targeting MET, VEGF, RON, AXL, and TIE-2 receptors.
Hepatocyte growth factor/c-Met signalling is important for the selection of transplanted hepatocytes.
GeneRIF
Streetz et al., Aachen, Germany. In Gut, 2012
HGF/c-Met plays a crucial role in host and donor cells of the liver for the cursiv selection of transplanted hepatocytes.
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.
GeneRIF
Laskin et al., United States. In Toxicol Appl Pharmacol, 2012
Stem cell-derived tyrosine kinase plays a role in regulating macriphage recruitment and activation in the liver following acetaminophen administration and in hepatotoxicity.
Conditional deletion of β-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis.
GeneRIF
Waltz et al., Cincinnati, United States. In Endocrinology, 2012
Data suggest an important role for beta-catenin downstream of Ron receptor signaling during the development of mammary tumorigenesis.
Expression and mutational status of RON in neoplastic lesions of the breast: analysis of MSP/RON signaling in ductal carcinoma in situ and invasive ductal carcinoma.
GeneRIF
Yokoyama et al., Ōita, Japan. In Apmis, 2012
Findings suggest the involvement of RON expression in the development of breast cancer, and that an autocrine/paracrine loop of RON seems to affect tumor invasiveness.
Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance.
GeneRIF
Zheng et al., Hangzhou, China. In Chin Med J (engl), 2012
Elevated RON expression may contribute to the occurrence, progression and metastasis of non-small cell lung cancer(NSCLC), inferring that it could be useful as a new prognostic indicator for patients with NSCLC.
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
Impact
Settleman et al., Palo Alto, United States. In Cancer Cell, 2009
Several of these genes encode pharmacologically tractable proteins, such as Syk and Ron kinases and integrin beta6, depletion of which induces epithelial-mesenchymal transformation (EMT) and apoptosis specifically in K-Ras-dependent cells.
Assessing the redundancy of MADS-box genes during carpel and ovule development.
Impact
Yanofsky et al., San Diego, United States. In Nature, 2003
AG is a member of a monophyletic clade of MADS-box genes that includes SHATTERPROOF1 (SHP1), SHP2 and SEEDSTICK (STK), indicating that these four genes might share partly redundant activities.
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