Roles and Regulation of Renal K Channels.
Baltimore, United States. In Annu Rev Physiol, Jan 2016
Recently, a confluence of discoveries in areas from human genetics to physiology, cell biology, and biophysics has cast light on the special function of five different potassium channels in the distal nephron, encoded by the genes KCNJ1, KCNJ10, KCNJ16, KCNMA1, and KCNN3.
ROMK Inhibitor Actions in the Nephron Probed with Diuretics.
In Am J Physiol Renal Physiol, Jan 2016
ROMK is an attractive diuretic target, in part, because its inhibition is postulated to indirectly inhibit the bumetanide-sensitive Na(+)-K(+)-2Cl- co-transporter, NKCC2, and the amiloride- and benzamil-sensitive epithelial Na(+) channel, ENaC.
Inhibitors of the renal outer medullary potassium channel: a patent review.
Pisa, Italy. In Expert Opin Ther Pat, 2014
In this panorama, inhibitors of the renal outer medullary potassium (ROMK) channels are emerging because they are predicted to give a diuretic/natriuretic activity higher than that provided by loop diuretics, without hypokaliemic and hyperkaliemic side effects.
Mouse models and the urinary concentrating mechanism in the new millennium.
Århus, Denmark. In Physiol Rev, 2007
These include the major renal water channels (aquaporins), urea transporters, ion transporters and channels (NHE3, NKCC2, NCC, ENaC, ROMK, ClC-K1), G protein-coupled receptors (type 2 vasopressin receptor, prostaglandin receptors, endothelin receptors, angiotensin II receptors), and signaling molecules.
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Tübingen, Germany. In Physiol Rev, 2006
SGKs activate ion channels (e.g., ENaC, TRPV5, ROMK, Kv1.3, KCNE1/KCNQ1, GluR1, GluR6), carriers (e.g., NHE3, GLUT1, SGLT1, EAAT1-5), and the Na+-K+-ATPase.