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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Rho-associated coiled-coil containing protein kinase 2

ROCK2, ROKalpha
a Rho kinase that is involved in inducing membrane blebbing and chromatin condensation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, Actin, Rho kinase, V1a
Papers using ROCK2 antibodies
Analyzing chemotaxis using the Dunn direct-viewing chamber
Ridley Anne J. et al., In The Journal of Cell Biology, 1996
... 611136; BD), ROCK2 C-20 (sc-1851; Santa Cruz Biotechnology, Inc.), mouse monoclonal ROCK2 ...
Papers on ROCK2
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Marshall et al., London, United Kingdom. In Elife, Feb 2016
Here we provide evidence that ROCK1 and ROCK2 act redundantly to maintain actomyosin contractility and cell proliferation and that their loss leads to cell-cycle arrest and cellular senescence.
Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease.
Lingor et al., Göttingen, Germany. In Brain Pathol, Feb 2016
Furthermore, the increase in protein expression of the growth-inhibitory protein ROCK2 in astrocytes and a similar trend in microglia, suggests an important role for ROCK2 in glial PD pathology, which is initiated already in normal aging.
The effect of sub-chronic systemic ethanol treatment on corpus cavernosal smooth muscle contraction: the contribution of RhoA/Rho-kinase.
Ogulener et al., Adana, Turkey. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2016
Also, ROCK1 expression was reduced by ethanol but not statically significant to sham-treated group; however, the expression of ROCK2 increased in ethanol group.
Novel Insights into the Roles of Rho Kinase in Cancer.
Shi et al., Indianapolis, United States. In Arch Immunol Ther Exp (warsz), Feb 2016
The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in the organization of the actin cytoskeleton, and is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, proliferation, and apoptosis.
Quantitative proteomics analysis to identify diffuse axonal injury biomarkers in rats using iTRAQ coupled LC-MS/MS.
Li et al., Chongqing, China. In J Proteomics, Jan 2016
Of the ten candidate DAI biomarkers, four proteins, citrate synthase (CS), synaptosomal-associated protein 25 (Snap25), microtubule-associated protein 1B (MAP1B) and Rho-associated protein kinase 2 (Rock2), were validated by subsequent Western blot and immunohistochemistry analyses.
Ozone-induced airway hyperresponsiveness: roles of ROCK isoforms.
Song et al., Birmingham, United States. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
Compared with wild-type (WT) mice, the authors report that ROCK1(+/-) and ROCK2(+/-) mice exhibited significantly reduced AHR following acute exposure to O3.
Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho/ROCK/NF-κB pathway.
Ma et al., Nanjing, China. In Neuropharmacology, Jan 2016
In parallel, we demonstrated that the expressions of RhoA, ROCK1, ROCK2, p-NF-κBp65, p-IκBα, p-IKKα and p-IKKβ were enhanced accompanying the investigation arthritis-induced cognition deficits, which were remarkably down-regulated by salidroside and confirmed by the results obtained from western blot and immunohistochemistry. LC-MS/MS results ascertained that Sal could enter into the blood and brain tissues to exhibit the protective effect on arthritis-induced cognitive dysfunction.
Urotensin-ⅡReceptor Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway.
Chen et al., Hefei, China. In Plos One, Dec 2015
Hemodynamic parameters, electrocardiogram (ECG), infarct size, histological alteration, lactate dehydrogenase (LDH), creatine phosphokinase-MB (CK-MB), cardiac troponin I (cTnI), RhoA, and the protein expressions of U-II receptor (UTR), ROCK1 and ROCK2 were evaluated.
MiR-124 Promote Neurogenic Transdifferentiation of Adipose Derived Mesenchymal Stromal Cells Partly through RhoA/ROCK1, but Not ROCK2 Signaling Pathway.
Guo et al., Harbin, China. In Plos One, Dec 2015
RhoA/ROCK1, but not ROCK2 is a downstream signaling pathway of miR-124 in the process of transdifferentiation. CONCLUSION: MiR-124 is an important miRNA modulating neurogenic transdifferentiation of ADMSCs at least partly via the miR-124/RhoA/ROCK1 signaling pathway.
Rho Kinases in Health and Disease: From Basic Science to Translational Research.
Loirand, Nantes, France. In Pharmacol Rev, Oct 2015
Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton dynamics downstream of Rho GTPases that participate in the control of important physiologic functions, S including cell contraction, migration, proliferation, adhesion, and inflammation.
The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis.
Liao et al., Chicago, United States. In Pharmacol Rev, 2014
Actin filament assembly and actomyosin contraction are directed by the Rho-associated coiled-coil forming protein kinase (ROCK) family of serine/threonine kinases (ROCK1 and ROCK2).
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.
Lutz et al., Göttingen, Germany. In Front Pharmacol, 2014
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC.
Anthrax toxin receptor 2a controls mitotic spindle positioning.
González-Gaitán et al., Genève, Switzerland. In Nat Cell Biol, 2013
Filamentous actin (F-actin) also forms an A-V polarized cap, which depends on Wnt/PCP and its effectors RhoA and Rock2.
Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular carcinoma cells.
Shao et al., Nanchang, China. In Exp Cell Res, 2012
A new role for Rock2 in modulation of Cdc25A ubiquitination has been revealed, indicating a novel mechanism of Cdc25A regulation and a potential function for Rock2 in the development of hepatocellular carcinoma.
Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
Brutkiewicz et al., Indianapolis, United States. In J Immunol, 2012
our overall results reveal a model whereby CD1d-mediated Ag presentation is negatively regulated by ROCK1 and ROCK2 via its effects on the actin cytoskeleton.
Molecular pathways regulating contractility in rat uterus through late gestation and parturition.
Mitchell et al., Newcastle upon Tyne, United Kingdom. In Am J Obstet Gynecol, 2012
The rhoA/rhoA-associated kinase pathway is a key regulator of uterine activation during labor and may be a useful target for the prevention of spontaneous preterm birth.
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Sheppard et al., San Francisco, United States. In Nat Med, 2012
Interleukin-17A (IL-17A), but not IL-17F or IL-22, enhanced contractile force generation of airway smooth muscle through an IL-17 receptor A (IL-17RA)-IL-17RC, nuclear factor κ light-chain enhancer of activated B cells (NF-κB)-ras homolog gene family, member A (RhoA)-Rho-associated coiled-coil containing protein kinase 2 (ROCK2) signaling cascade.
Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.
Hotchin et al., Birmingham, United Kingdom. In Plos One, 2011
ROCK1 and ROCK2 have distinct and separate roles in adhesion complex assembly and turnover in human epidermal keratinocytes.
Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO/PKG pathway in the bile-duct-ligated rat.
Li et al., Guangzhou, China. In Plos One, 2011
Spironolactone lowers portal hypertension by improvement of liver fibrosis and inhibition of intrahepatic vasoconstriction via down-regulating ROCK-2 activity and activating NO/PKG pathway
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Olson et al., Glasgow, United Kingdom. In Cancer Cell, 2011
To determine how actomyosin tension affects tissue homeostasis and tumor development, we expressed conditionally active ROCK2 in mouse skin.
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