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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Roundabout, axon guidance receptor, homolog 4

Robo4, MRB, Magic roundabout
Top mentioned proteins: Robo1, V1a, Angiotensin II, HAD, Slit2
Papers on Robo4
New insights into implication of the SLIT/ROBO pathway in the prehierarchical follicle development of hen ovary.
Xu et al., Changchun, China. In Poult Sci, Sep 2015
The aims of the present study were to examine the spatial and temporal expression of the SLIT ligand genes (SLIT1, SLIT2, and SLIT3) and their receptor ROBO1, ROBO2, ROBO3, and ROBO4 genes in various-sized prehierarchical follicles during hen ovary development and the effects of activin A and inhibin A on the expression of these genes in the cultured hen follicles.
Diagnostic SNPs reveal widespread introgressive hybridization between introduced bighead and silver carp in the Mississippi River Basin.
Sass et al., Urbana, United States. In Mol Ecol, Aug 2015
Following their introduction to North America, however, introgressant hybrids have been reported throughout their expanded range within the Mississippi River Basin (MRB).
A tunable isoelectric focusing via moving reaction boundary for two-dimensional gel electrophoresis and proteomics.
Cao et al., Shanghai, China. In Talanta, May 2015
Based on the concept of moving reaction boundary (MRB), we firstly proposed a tunable non-IPG-IEF system to address these issues.
ROBO4-mediated vascular integrity regulates the directionality of hematopoietic stem cell trafficking.
Forsberg et al., Santa Cruz, United States. In Stem Cell Reports, Mar 2015
Surprisingly, we found that instead of acting as barriers to cellular entry, vascular endothelial cells, via the guidance molecule ROBO4, actively promote HSC translocation across vessel walls into the BM space.
Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA Editing.
Cruz-Reyes et al., Oklahoma City, United States. In Plos One, 2014
Here, we identify the first specialized functions in MRBs: 1) 3010-MRB is a major scaffold for RNA editing, and 2) REH2-MRB contains a critical trans-acting RNA helicase (REH2) that affects multiple steps of editing function in 3010-MRB.
Clinical and prognostic implications of Roundabout 4 (robo4) in adult patients with acute myeloid leukemia.
Tien et al., Taipei, Taiwan. In Plos One, 2014
BACKGROUND: Robo4 is involved in hematopoietic stem/progenitor cell homeostasis and essential for tumor angiogenesis.
Greater efficacy of aldosterone blockade and diuretic reinforcement vs. dual renin-angiotensin blockade for left ventricular mass regression in patients with resistant hypertension.
Plouin et al., Paris, France. In J Hypertens, 2014
OBJECTIVES: We report the results of an echocardiographic substudy carried out in a trial comparing the effects of two different treatment strategies - mineralocorticoid receptor blockade (MRB) and dual renin-angiotensin system blockade (RASB) - in patients with resistant hypertension.
The myeloid-binding peptide adenoviral vector enables multi-organ vascular endothelial gene targeting.
Arbeit et al., Saint Louis, United States. In Lab Invest, 2014
Swapping the EC-specific ROBO4 for the CMV promoter/enhancer abrogated hepatocyte expression but also reduced gene expression in other organs.
Retardation signal for fluorescent determination of total protein content via rapid and sensitive chip moving reaction boundary electrophoretic titration.
Cao et al., Shanghai, China. In Anal Chem, 2014
A novel concept and theory of moving reaction boundary (MRB) retardation signal (RMRB) was advanced for determination of total protein content via MRB electrophoretic titration (MRBET).
Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitor or angiotensin II receptor blocker treatment: an emerging paradigm in diabetic nephropathy: a systematic review.
Martin et al., Genève, Switzerland. In Eur J Intern Med, 2014
A subset of patients in each study also received a mineralocorticoid receptor blocker (MRB) (either spironolactone or eplerenone) in addition to standard treatment.
Pharmacotherapy to reduce arrhythmic mortality.
Kulkarni et al., India. In Indian Heart J, 2014
Although anti-arrhythmic drugs (AAD) appear inferior to ICD, the role of beta-blockers and to an extent amiodarone along with non AAD like angiotensin converting enzyme inhibitors (ACE-I), mineralocorticoid blockers (MRB) and HMG-CoA reductase inhibitors (statins) need to be emphasized.
Role of ROBO4 signalling in developmental and pathological angiogenesis.
Narayan et al., Benares, India. In Biomed Res Int, 2013
Transmembrane roundabout receptor family members (ROBO1-ROBO4) principally orchestrate the neuronal guidance mechanism of the nervous system.
[Determination of total protein content in soya-bean milk via visual moving reaction boundary titration].
Cao et al., Shanghai, China. In Se Pu, 2013
During the process, moving reaction boundary (MRB) was formed by hydroxyl ions in the catholyte and soya-bean milk proteins immobilized in polyacrylamide gel (PAG), and an acid-base indicator was used to denote the boundary motion.
Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations.
Forsberg et al., Santa Cruz, United States. In Cell Cycle, 2012
Data found that expression of Slit2 and SDF1 were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.
Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability.
Groopman et al., Boston, United States. In Plos Pathog, 2012
targeting Slit2/Robo4 signaling may protect the integrity of the lymphatic barrier and limit the dissemination of HIV in the host.
Mineralocorticoid receptor blockade in chronic kidney disease.
Klemmer et al., New York City, United States. In Blood Purif, 2011
Low-dose MRB therapy may offer additional antihypertensive and unique anti-inflammatory benefits in select CKD populations.
Activation of endothelial roundabout receptor 4 reduces the severity of virus-induced keratitis.
Rouse et al., Knoxville, United States. In J Immunol, 2011
augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis
Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm.
Li et al., Salt Lake City, United States. In Curr Opin Hematol, 2011
REVIEW: Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm
Expression and roles of Slit/Robo in human ovarian cancer.
Zheng et al., Jinan, China. In Histochem Cell Biol, 2011
Protein expression of Slit2/3 and Robo1/4 was also identified in OVCAR-3 and SKOV-3 cells.
Cheng, Bethesda, United States. In Unknown Journal, 2006
The (S,S)-MeNER enantiomer ((S,S)-MRB) is the more potent enantiomer with a IC50 of 3.6 nM for inhibiting NE uptake in rat hypothalamic synaptosomes.
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