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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Roundabout, axon guidance receptor, homolog 1

Robo1, Roundabout, DUTT1
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: Slit2, CAN, Robo2, Midline, Robo4
Papers on Robo1
Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling.
New
Chen et al., Taipei, Taiwan. In Cell Adh Migr, Feb 2016
UNASSIGNED: The objective of this study was to investigate whether human placental multipotent mesenchymal stromal cell (hPMSC)-derived Slit2 and endothelial cell Roundabout (Robo) receptors are involved in placental angiogenesis.
Pulmonary neuroendocrine cells function as airway sensors to control lung immune response.
New
Impact
Sun et al., Madison, United States. In Science, Feb 2016
Here we show that Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population.
Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4.
New
Hamakubo et al., Tokyo, Japan. In Biochem Biophys Res Commun, Jan 2016
UNASSIGNED: Slit proteins and their receptors, the Roundabout (Robo) family, are known to have a pivotal role in the vascular system.
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization.
New
Eichmann et al., Paris, France. In Circulation, Jan 2016
Mechanistically, NCK binding to ROBO1 is required for both Slit2 and VEGF induced front-rear polarity.
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.
New
Impact
Chédotal et al., Paris, France. In Nat Med, May 2015
Slit-family proteins (Slits) are ligands of Roundabout (Robo) receptors that repel developing axons in the nervous system.
Slit2-Robo signaling in inflammation and kidney injury.
Review
New
Robinson et al., Vellore, India. In Pediatr Nephrol, Apr 2015
In this review, we summarize recent findings demonstrating that the neuronal guidance cues, Slit and Roundabout (Robo), prevent the migration of multiple leukocyte subsets towards diverse inflammatory chemoattractants, and have potent anti-platelet functions in vitro and in vivo.
Slit/Robo pathway: a promising therapeutic target for cancer.
Review
Chauhan et al., Memphis, United States. In Drug Discov Today, 2015
Axon guidance molecules, slit glycoprotein (Slit) and Roundabout receptor (Robo), have implications in the regulation of physiological processes.
Epigenetic Repression of miR-218 Promotes Esophageal Carcinogenesis by Targeting ROBO1.
Yin et al., Nanjing, China. In Int J Mol Sci, 2014
miR-218 suppressed cell proliferation and arrested cells at G1 phase by targeting 3' untranslated region (3'UTR) of roundabout guidance receptor 1 (ROBO1).
The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers.
To et al., Hong Kong, Hong Kong. In Bmc Cancer, 2014
The Roundabout (ROBO) receptors and their secreted SLIT glycoprotein ligands, which were originally identified as important axon guidance molecules, have implication in the regulation of neurons and glia, leukocytes, and endothelial cells migration.
[Advance studies of Slit-Robo signal pathway and its roles in ocular neovascularisation].
Review
Zhao et al., Tianjin, China. In Zhonghua Yan Ke Za Zhi, 2014
Slits and their Roundabout (Robo) receptors were initially characterized as repulsive guidance cues for neuronal axons and mediate the migration of neuronal precursor cells during neural development.
Role of ROBO4 signalling in developmental and pathological angiogenesis.
Review
Narayan et al., Benares, India. In Biomed Res Int, 2013
Transmembrane roundabout receptor family members (ROBO1-ROBO4) principally orchestrate the neuronal guidance mechanism of the nervous system.
Roundabout receptors.
Review
Chedotal et al., In Adv Neurobiol, 2013
Roundabout receptors (Robo) and their Slit ligands were discovered in the 1990s and found to be key players in axon guidance.
Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth.
GeneRIF
López-Bendito et al., Alacant, Spain. In Nat Neurosci, 2012
Modifications to spontaneous calcium activity encode a switch in the axon outgrowth program that allows establishment of specific neuronal connections through the transcriptional regulation of Slit1 and Robo1 signaling.
Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling.
GeneRIF
Kaprielian et al., United States. In Development, 2012
Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling
Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.
GeneRIF
Bashaw et al., Philadelphia, United States. In Dev Biol, 2012
Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 specify the position of longitudinal axon pathways.
Human ROBO1 regulates interaural interaction in auditory pathways.
GeneRIF
Hari et al., Espoo, Finland. In J Neurosci, 2012
The results of this study indicated that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.
Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology.
GeneRIF
DeAngelis et al., Boston, United States. In Plos One, 2010
distinct ROBO1 variants may influence the risk of wet and dry AMD, and the effects of ROBO1 on AMD risk may be modulated by RORA variants.
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.
Impact
Li et al., Salt Lake City, United States. In Nat Cell Biol, 2009
Slit-Roundabout (Robo) signalling has a well-understood role in axon guidance.
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.
Impact
Li et al., Salt Lake City, United States. In Nat Med, 2008
The Roundabout (Robo) proteins are guidance receptors with well-established functions in the nervous system; however, their role in the mammalian vasculature remains ill defined.
Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity.
Impact
Geng et al., Shanghai, China. In Cancer Cell, 2003
Slit is a secreted protein known to function through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, and as an inhibitor in leukocyte chemotaxis.
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