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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ring finger protein 31

RNF31, Zibra
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, RBCK1, CAN, Incontinentia Pigmenti, V1a
Papers on RNF31
miR-503 suppresses tumor cell proliferation and metastasis by directly targeting RNF31 in prostate cancer.
New
Wang et al., Wuhan, China. In Biochem Biophys Res Commun, Oct 2015
RNF31 mRNA expressions in tumor tissues and benign prostate tissues were evaluated.
RING finger protein 31 promotes p53 degradation in breast cancer cells.
New
Dahlman-Wright et al., Stockholm, Sweden. In Oncogene, Aug 2015
UNASSIGNED: The atypical E3 ubiquitin ligase RNF31 is highly expressed in human breast cancer, the most frequent neoplastic lethality among women.
[Lentivirus-mediated interference of E3 ubiquitin ligase RNF31 inhibits tumor-necrosis factor-α-induced activation of nuclear factor-κB pathway].
Yu et al., Tianjin, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
OBJECTIVE: To study the effect of E3 ubiquitin ligase RNF31 knockdown on nuclear factor-κB (NF-κB) pathway activation and cell apoptosis.
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling.
Pouwels et al., Turku, Finland. In Plos One, 2014
We map the integrin binding site on SHARPIN to the ubiquitin-like (UBL) domain, the same domain implicated in SHARPIN interaction with LUBAC component RNF31 (ring finger protein 31), and identify two SHARPIN residues (V267, L276) required for both integrin and RNF31 regulation.
The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation.
Dahlman-Wright et al., Huddinge, Sweden. In Oncogene, 2014
Here we report that the atypical E3 ubiquitin ligase RNF31 stabilizes ERα and facilitates ERα-stimulated proliferation in breast cancer cell lines.
Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.
Staudt et al., Stuttgart, Germany. In Cancer Discov, 2014
Two germline polymorphisms affecting the LUBAC subunit RNF31 are rare among healthy individuals (∼1%) but enriched in ABC DLBCL (7.8%).
Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling.
Dikic et al., Frankfurt am Main, Germany. In Cancer Discov, 2014
Two rare germline single-nucleotide polymorphisms in the RNF31 gene have been identified as being responsible.
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Impact
Cordes et al., Toronto, Canada. In Nature, 2013
Gumby interacts with HOIP (also called RNF31), a key component of the linear ubiquitin assembly complex, and decreases linear ubiquitination and activation of NF-κB-dependent transcription.
A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.
GeneRIF
Kato et al., Nagoya, Japan. In Embo Rep, 2012
The study highlights the versatility and specificity of protein-protein interactions involving Ub-like domain (UBL) of HOIL-1L/the Ub-associated domain (UBA) of HOIP and their cognate proteins.
Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells.
GeneRIF
Treuter et al., Huddinge, Sweden. In Plos One, 2011
Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFbeta, and Wnt/beta-catenin signaling in adrenocortical carcinoma cells.
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Impact
Dikic et al., Frankfurt am Main, Germany. In Nature, 2011
Upon binding to the LUBAC subunit HOIP (also known as RNF31), SHARPIN stimulates the formation of linear ubiquitin chains in vitro and in vivo.
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.
Impact
Iwai et al., Suita, Japan. In Nature, 2011
Thus, we re-define LUBAC as a complex containing SHARPIN, HOIL-1L, and HOIP (also known as RNF31).
Linear ubiquitination prevents inflammation and regulates immune signalling.
Impact
Walczak et al., London, United Kingdom. In Nature, 2011
Recently linear ubiquitin chains assembled by a complex containing HOIL-1 and HOIP (also known as RBCK1 and RNF31, respectively) were implicated in TNF signalling, yet their relevance in vivo remained uncertain.
SHARPIN negatively associates with TRAF2-mediated NFκB activation.
Liang, New Haven, United States. In Plos One, 2010
However, in vitro studies demonstrated that SHARPIN activates NFκB signaling by forming a linear ubiquitin chain assembly complex with RNF31 (HOIP) and RBCK1 (HOIL1).
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
Colgan et al., Iowa City, United States. In Plos One, 2009
In addition to known CD40-interacting proteins, we detected SMAC/DIABLO, HTRA2/Omi, and HOIP/RNF31/PAUL/ZIBRA.
E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis.
GeneRIF
Treuter et al., Huddinge, Sweden. In Mol Cell Biol, 2009
RNF31 functions to stabilize DAX-1; RNF31 appears to be required for DAX-1 to repress transcription
Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells.
GeneRIF
Brody et al., Irvine, United States. In Exp Cell Res, 2004
ZIBRA was identified and its genomic organization, regulation, and expression studied in breast cancer cells.
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