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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ring finger protein 17

Rnf17, Mmip-2, Tdrd4
This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: 18 U, CAN, ACID, HAD, Smad1
Papers on Rnf17
RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.
Hannon et al., New York City, United States. In Genes Dev, Aug 2015
Here we show that RNF17 shapes adult meiotic piRNA content by suppressing the production of secondary piRNAs.
Male and female rat bone marrow-derived mesenchymal stem cells are different in terms of the expression of germ cell specific genes.
Ghasemzadeh-Hasankolaei et al., Bābol, Iran. In Anat Sci Int, Jun 2015
Therefore, for the first time, this study attempts to assay and determine the differences between the expression levels of some important GC-specific genes (Stra8, Vasa, Dazl, Stella, Piwil2, Oct4, Fragilis, Rnf17 and c-Kit) in male and female bone marrow (BM)-MSCs of rats.
Ectopic expression of DAZL gene in goat bone marrow-derived mesenchymal stem cells enhances the trans-differentiation to putative germ cells compared to the exogenous treatment of retinoic acid or bone morphogenetic protein 4 signalling molecules.
Wang et al., Nanjing, China. In Cell Biol Int, 2015
Both RA and BMP4 induced OCT4, MVH, DAZL, STELLA, NANOG and C-KIT expression, but RNF17, PIWIL2, STRA8, and SCP3 were only expressed after RA treatment.
Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data.
Emmert-Streib et al., Tampere, Finland. In Bmc Syst Biol, 2014
Furthermore, the identified hub genes of the individual GRNs, e.g., HID1/DMC1 (tumor development), RNF17/TDRD4 (cancer antigen) and CYP4A11 (angiogenesis/ metastasis) are known cancer associated markers.
Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.
Gui et al., Shenzhen, China. In Sci Rep, 2014
We found a significant excess of rare, non-silent variants in genes that are key epigenetic regulators of spermatogenesis, such as BRWD1, DNMT1, DNMT3B, RNF17, UBR2, USP1 and USP26, in NOA patients (P = 5.5 × 10(-7)), corresponding to a carrier frequency of 22.5% of patients and 13.7% of controls (P = 1.4 × 10(-5)).
STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.
Wang et al., Columbus, United States. In Plos One, 2013
One group, consisting of TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing, while the other group including RNF17/TDRD4 and TDRD5-7 are required for spermiogenesis.
Human second trimester amniotic fluid cells are able to create embryoid body-like structures in vitro and to show typical expression profiles of embryonic and primordial germ cells.
Stuppia et al., Chieti, Italy. In Cell Transplant, 2013
RT-PCR analysis, carried out at different culture times (second, third, fourth, fifth, and eighth passages), revealed the presence of specific markers of ESCs (such as FGF4 and DAPPA4), as well as of markers typical of PGCs and, in particular, genes involved in early stages of germ cell development (Fragilis, Stella, Vasa, c-Kit, Rnf17).
Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer.
Kim et al., Seoul, South Korea. In Tohoku J Exp Med, 2010
TDRD4 mRNA is expressed in a subset of liver cancers, and TDRD4 is a candidate CT antigen for liver cancer.
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.
Pawson et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2010
A group of germline specific single and multiTudor domain containing proteins (TDRDs) represented by drosophila Tudor and its mammalian orthologs Tdrd1, Tdrd4/RNF17, and Tdrd6 play evolutionarily conserved roles in germinal granule/nuage formation and germ cell specification and differentiation.
Presumptive germ cells derived from mouse pluripotent somatic cell hybrids.
Kerkis et al., São Paulo, Brazil. In Differentiation, 2009
Presumptive GC obtained reacted positively with anti-EMA, Vasa, Fragilis and Dazl antibodies and expressed GC-specific genes, such as Vasa, Stella, Dazl, Piwil 2, Tex14, Bmp8b, Tdrd1 and Rnf17.
Derivation of male germ cells from bone marrow stem cells.
Engel et al., Göttingen, Germany. In Lab Invest, 2006
BMS cell-derived germ cells expressed the known molecular markers of primordial germ cells, such as fragilis, stella, Rnf17, Mvh and Oct4; as well as molecular markers of spermatogonial stem cells and spermatogonia including Rbm, c-Kit, Tex18, Stra8, Piwil2, Dazl, Hsp90alpha, beta1- and alpha6-integrins.
RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.
Wang et al., Philadelphia, United States. In Development, 2005
RNF17 is required for spermiogenesis in mouse. There are two RNF17 protein isoforms: RNF17L and RNF17S. RNF17 localizes to a novel nuage in germ cells.
Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones.
Prochownik et al., Pittsburgh, United States. In Oncogene, 2001
Mmip-2/Rnf-17 is a RING-finger protein that interacts with all four known Mad proteins, redistributes them to the cytoplasm, and thus enhances c-Myc function.
Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.
Radomski et al., Edmonton, Canada. In Cancer Res, 2001
This aggregation resulted in the release of MMIP-2 from platelets and cancer cells, as measured by zymography.
Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network.
Prochownik et al., Pittsburgh, United States. In Oncogene, 1999
Using the bHLH-ZIP domain of mad1 as a yeast two-hybrid 'bait', we identified Mmip-2, a novel RING finger protein that interacts with all mad members, but weakly or not at all with c-myc, max or unrelated bHLH or bZIP proteins.
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