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Rho family GTPase 2

Rnd2, Rho7, RhoN
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, MLK3, RhoA, Actin, FBP17
Papers using Rnd2 antibodies
Rho GTPases and signaling networks
Supplier
Chardin Pierre et al., In The Journal of Cell Biology, 1996
... To confirm that the ATG of Rnd2 had been properly assigned as the start codon, we used the Marathon 5′ Race technique (CLONTECH ...
Papers on Rnd2
The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.
New
Tan et al., Melbourne, Australia. In Cereb Cortex, Mar 2015
Loss of RP58 within the embryonic cortex also leads to elevated mRNA for Rnd2, a member of the Rnd family of atypical RhoA-like GTPase proteins important for cortical neuron migration (Heng et al. 2008).
Analysis of RhoE expression in the testis, epididymis and ductus deferens, and the effects of its deficiency in mice.
Terrado et al., Valencia, Spain. In J Anat, 2014
Rnd1, Rnd2 and RhoE/Rnd3 form a subfamily of Rho proteins characterized by being constitutively active.
Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex.
Heng et al., Australia. In Neural Dev, 2014
We previously reported that the atypical RhoA GTPase Rnd2 promotes the radial migration of mouse cerebral cortical neurons (Nature 455(7209):114-8, 2008; Neuron 69(6):1069-84, 2011), but its downstream signalling pathway is not well understood.
Scratch2 modulates neurogenesis and cell migration through antagonism of bHLH proteins in the developing neocortex.
Stoykova et al., Göttingen, Germany. In Cereb Cortex, 2014
Mechanistically, our results indicate that Scrt2 negatively regulates the transcriptional activation of the basic helix loop helix TFs Ngn2/NeuroD1 on E-box containing common target genes, including Rnd2, a well-known major effector for migrational defects in developing cortex.
An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.
Guillemot et al., London, United Kingdom. In Nat Commun, 2013
Previous work has shown that proneural factors also confer a migratory behaviour to cortical neurons by inducing the expression of the small GTP-binding proteins such as Rnd2 and Rnd3.
Interaction characteristics of Plexin-B1 with Rho family proteins.
Ahmadian et al., Düsseldorf, Germany. In Biochem Biophys Res Commun, 2013
We show that B1RBD binds in a GTP-dependent manner to Rac1, Rac2, Rac3, Rnd1, Rnd2, Rnd3, and RhoD, but not to RhoA, Cdc42, RhoG, or Rif.
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
Impact
Ridley et al., London, United Kingdom. In Cell, 2013
Rnd1, Rnd2, and geranylgeranylated Rap1A interact similarly with 14-3-3.
RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex.
Okado et al., Tokyo, Japan. In Cell Rep, 2013
Finally, we found that RP58 represses Ngn2 transcription to regulate the Ngn2-Rnd2 pathway; Ngn2 knockdown rescued migration defects of the RP58(-/-) neurons.
Rnd3 induces stress fibres in endothelial cells through RhoB.
Ridley et al., London, United Kingdom. In Biol Open, 2013
Rnd1 and Rnd3/RhoE induce loss of actin stress fibres and cell rounding in multiple cell types, whereas responses to Rnd2 are more variable.
Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis.
Davidson et al., Iowa City, United States. In Neuroscience, 2012
Doublecortin and Rnd2 were also increased and showed altered distribution, supporting a strong regulatory role for miRNAs in both early and late neuronal migration.
The GTPase-deficient Rnd proteins are stabilized by their effectors.
Manser et al., Singapore, Singapore. In J Biol Chem, 2012
Here we demonstrated that Rnd1, Rnd2, and Rnd3 stability is acutely dependent on interaction with their effectors such as Syx or p190 RhoGAP.
Lysophosphatidic acid induces neurite branch formation through LPA3.
Fukushima et al., Japan. In Mol Cell Neurosci, 2012
Furthermore, expression of inhibitory mutants of the small GTPase Rnd2/Rho7 or an Rnd2 effector rapostlin abolished LPA(3)-mediated neurite branching.
COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.
GeneRIF
Studer et al., Napoli, Italy. In Development, 2011
Data demonstrate that COUP-TFI modulates late-born neuron migration and favours proper differentiation of callosal projection neurons by finely regulating Rnd2 expression levels.
Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1.
GeneRIF
Negishi et al., Kyoto, Japan. In J Biol Chem, 2009
Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity.
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Impact
GeneRIF
Guillemot et al., London, United Kingdom. In Nature, 2008
results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration
Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.
GeneRIF
Negishi et al., Kyoto, Japan. In J Biol Chem, 2006
Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling
Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria.
GeneRIF
Ozaki et al., Tokyo, Japan. In Comp Biochem Physiol A Mol Integr Physiol, 2005
The RND2 mRNA levels increased significantly was expressed in nonpregnant rat myometrium.
Function and regulation of RhoE.
Review
Ridley et al., London, United Kingdom. In Biochem Soc Trans, 2005
The three Rnd proteins, Rnd1, Rnd2 and RhoE/Rnd3, are a subset of Rho family proteins that are unusual in that they bind but do not hydrolyse GTP, and are therefore not regulated by the classical GTP/GDP conformational switch of small GTPases.
Rho family GTPases and dendrite plasticity.
Review
Katoh et al., Kyoto, Japan. In Neuroscientist, 2005
Recently, other members of Rho family GTPases, including Rnd1 and Rnd2, have also been shown to be involved in the regulation of dendrite development.
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