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ATP-binding cassette, sub-family E

RLI, RNase L inhibitor, ABCE1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ATPase, V1a, HAD, IRF
Papers on RLI
ABCE1 plays an essential role in lung cancer progression and metastasis.
New
Tian et al., Shenyang, China. In Tumour Biol, Feb 2016
UNASSIGNED: ATP-binding cassette E1 (ABCE1) is a member of the ATP-binding cassette transporters and regulates a broad range of biological functions including viral infection, cell proliferation, and anti-apoptosis.
β-Radioluminescence Imaging: A Comparative Evaluation with Cerenkov Luminescence Imaging.
New
Xing et al., Xi'an, China. In J Nucl Med, Sep 2015
In this study, we proposed a new modality, termed β-radioluminescence imaging (β-RLI), which incorporates a scintillator with a γ-rejection strategy for imaging β particles.
Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo.
New
Impact
Green et al., Bethesda, United States. In Cell, Sep 2015
To study the function of Rli1/ABCE1 in vivo, we used ribosome profiling and biochemistry to characterize its contribution to ribosome recycling.
Effects of silencing the ATP-binding cassette protein E1 gene by electroporation on the proliferation and migration of EC109 human esophageal cancer cells.
New
Zhang et al., Xinxiang, China. In Mol Med Report, Jul 2015
In the present study, the gene expression of ATP-binding cassette protein E1 (ABCE1) in the EC109 human esophageal cancer cell line was silenced using electroporation to examine the effect if the ABCE1 gene on the growth migration and cell cycle of cancer cells.
Gene expression profile of ABC transporters and cytotoxic effect of ibuprofen and acetaminophen in an epithelial ovarian cancer cell line in vitro.
New
da Silva Filho et al., Belo Horizonte, Brazil. In Rev Bras Ginecol Obstet, Jun 2015
TOV-21 G cells had a reduced expression of the genes ABCA1, ABCC3, ABCC4, ABCD3, ABCD4 and ABCE1 within the ABC transporter superfamily.
Multiple mechanisms of reinitiation on bicistronic calicivirus mRNAs.
New
Pestova et al., United States. In Mol Cell, Apr 2015
We found that post-termination ribosomal tethering of mRNA by TURBS allows reinitiation by post-termination 80S ribosomes and diminishes dependence on eukaryotic initiation factor 3 (eIF3) of reinitiation by recycled 40S subunits, which can be mediated either by eIFs 2/1/1A or by Ligatin following ABCE1-dependent or -independent splitting of post-termination complexes.
MicroRNA-299-3p promotes the sensibility of lung cancer to doxorubicin through directly targeting ABCE1.
Xing et al., Nanyang, China. In Int J Clin Exp Pathol, 2014
In the present study, miR-299-3p was down-expressed in doxorubicin-resistant or -sensitive lung cancer samples and it was identified to directly targeted adenosine triphosphate binding cassette E1 (ABCE1) 3'-untranslated region (UTR) in lung cancer H69 cells by luciferase assay.
Effect of ABCE1-silencing gene, transfected by electrotransfer, on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells.
Zhang et al., Tianjin, China. In Genet Mol Res, 2014
We investigated the effect of an ABCE1-silencing gene on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells.
Leptin action in the midbrain: From reward to stress.
Review
Xu, Nijmegen, Netherlands. In J Chem Neuroanat, 2014
Then, attention is given to various interactions of leptin with the midbrain regions, including ventral tegmental area (VTA), substantia nigra pars compacta (SNc), rostral linear raphe (RLi) and centrally-projecting Edinger-Westphal nucleus (EWcp).
Mitochondrial iron-sulfur protein biogenesis and human disease.
Review
Lill et al., Marburg an der Lahn, Germany. In Biochimie, 2014
In fact, it is this process that renders mitochondria essential for viability of virtually all eukaryotes, because they participate in the synthesis of the Fe/S clusters of key nuclear and cytosolic proteins such as DNA polymerases, DNA helicases, and ABCE1 (Rli1), an ATPase involved in protein synthesis.
An interstitial 4q31.21q31.22 microdeletion associated with developmental delay: case report and literature review.
Review
Syrrou et al., Ioánnina, Greece. In Cytogenet Genome Res, 2013
(145,963,820- 147,044,764), its size is 0.9-1.1 Mb, and it contains 7 genes (ABCE1, OTUD4, SMAD1, MMAA, C4orf51, ZNF827, and ANAPC10) as well as 5 retrotransposon-derived pseudogenes.
Tying up loose ends: ribosome recycling in eukaryotes and archaea.
Review
Tampé et al., Frankfurt am Main, Germany. In Trends Biochem Sci, 2013
It requires the ABC-type ATPase ABCE1 [previously named RNase L inhibitor (Rli)1 or host protein (HP)68], but the reaction and its regulation remain enigmatic.
Rustless translation.
Review
Hopfner, München, Germany. In Biol Chem, 2012
However, the function of the ABCE1, the only member of subfamily E of ABC proteins, remained mysterious for over a decade, even though it is perhaps the most conserved ABC protein in eukaryotes and archaea.
HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly.
GeneRIF
Lingappa et al., Seattle, United States. In J Cell Biol, 2012
To form HIV-1 capsid assembly intermediates, HIV-1 Gag co-opts a complex found in infected and uninfected cells that contains the cellular ATPase ABCE1 and the RNA helicase DDX6, both of which facilitate HIV-1 capsid assembly.
Role of the ABCE1 gene in human lung adenocarcinoma.
GeneRIF
Tian et al., China. In Oncol Rep, 2012
Report high expression level of ABCE1 mRNA and protein in human lung adenocarcinoma tissues and metastatic lymph nodes, which was also correlated with clinical stages.
Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.
Impact
Beckmann et al., München, Germany. In Nature, 2012
In the eukaryotic and archaeal kingdoms, however, recycling involves the ABC-type ATPase ABCE1 and little is known about its structural basis.
Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.
GeneRIF
Pisarev et al., United States. In Embo J, 2011
Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1.
A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer.
GeneRIF
Zheng et al., China. In Int J Mol Med, 2010
Results suggest that ABCE1 plays an important role in the pathogenesis of human small cell lung cancer cell.
The role of ABCE1 in eukaryotic posttermination ribosomal recycling.
GeneRIF
Pestova et al., United States. In Mol Cell, 2010
NTP hydrolysis by ABCE1 is stimulated by posttermination complexes and is required for its ribosomal recycling activity.
Identification of a host protein essential for assembly of immature HIV-1 capsids.
Impact
GeneRIF
Lingappa et al., San Francisco, United States. In Nature, 2002
host protein essential for assembly of immature HIV-1 capsids
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