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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PR domain containing 2, with ZNF domain

RIZ1, RIZ, PRDM2, RIZ2, zinc-finger DNA-binding protein
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: Qin, Histone, Blimp-1, CAN, POLYMERASE
Papers on RIZ1
The Multifaceted Roles of PRDM16: Adipose Biology and Beyond.
Review
New
Cohen et al., New York City, United States. In Trends Endocrinol Metab, Jan 2016
The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] protein family is involved in a spectrum of biological processes including cell fate determination and development.
Tumor suppressor RIZ1 in obesity and the PI3K/AKT/mTOR pathway.
New
Huang et al., Changsha, China. In Obesity (silver Spring), Jan 2016
OBJECTIVE: The aim of this study was to investigate the shared molecular pathways of obesity and cancer by exploring the role of RIZ1 in obesity and the phospatidylinositol 3-kinase (PI3K)/V-Akt murine thymoma viral oncogene homolog (PKB) (AKT)/mechanistic target of rapamycin (mTOR) pathway.
Identification of PRDM2 regulated genes in quiescent C2C12 myoblasts.
New
Dhawan et al., Bengaluru, India. In Genom Data, Dec 2015
We identified a tumor suppressor PRDM2, as an epigenetic regulator induced in quiescent muscle stem cells as well as in cultured quiescent myoblasts.
Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection.
New
Jung et al., Seoul, South Korea. In Medicine (baltimore), Dec 2015
A region containing PRDM2 was amplified only in the p16 group, whereas EGFR and 11q13.3
Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing.
New
Cai et al., Shenzhen, China. In Oncotarget, Dec 2015
We uncovered that MLL, EP400, PRDM2, ANK3 and CHD5 exclusively altered in recurrent BCs.
Evolution of Prdm Genes in Animals: Insights from Comparative Genomics.
New
Kerner et al., Paris, France. In Mol Biol Evol, Dec 2015
UNASSIGNED: Prdm genes encode transcription factors with a subtype of SET domain known as the PRDF1-RIZ (PR) homology domain and a variable number of zinc finger motifs.
Detecting abnormal methylation of tumor suppressor genes GSTP1, P16, RIZ1, and RASSF1A in hepatocellular carcinoma and its clinical significance.
New
Ding et al., Nanjing, China. In Oncol Lett, Oct 2015
By using methylation-specific polymerase chain reaction (MSP), the present study detected the methylation status in the promoter region of 4 candidate TSGs, GSTP1, P16, RIZ1, and RASSF1A, respectively, in 35 paired HCC and tumor-adjacent liver tissues in addition to 20 normal liver tissues.
Clinicopathological correlates of hyperparathyroidism.
Review
New
Mete et al., Toronto, Canada. In J Clin Pathol, Oct 2015
Recently, molecular mechanisms underlying possible tumour suppressor genes (MEN1, CDC73/HRPT2, CDKIs, APC, SFRPs, GSK3β, RASSF1A, HIC1, RIZ1, WT1, CaSR, GNA11, AP2S1) and proto-oncogenes (CCND1/PRAD1, RET, ZFX, CTNNB1, EZH2) have been uncovered in the pathogenesis of hyperparathyroidism.
Transcriptional regulator PRDM12 is essential for human pain perception.
New
Impact
Senderek et al., Cambridge, United Kingdom. In Nat Genet, Jul 2015
Here we identified 10 different homozygous mutations in PRDM12 (encoding PRDI-BF1 and RIZ homology domain-containing protein 12) in subjects with CIP from 11 families.
Epigenetic alterations in human parathyroid tumors.
Review
New
Corbetta et al., San Donato Milanese, Italy. In Endocrine, Jun 2015
Impaired expression of the histone methyltransferases EZH2, BMI1, and RIZ1 have been described in parathyroid tumors.
RIZ1: a potential tumor suppressor in glioma.
Lu et al., Shanghai, China. In Bmc Cancer, 2014
BACKGROUND: Retinoblastoma protein-interacting zinc-finger gene 1 (RIZ1) displays strong tumor suppressive activities, and its expression is often silenced in many types of human tumors.
Genetic variation of XPA gene and risk of cancer: a systematic review and pooled analysis.
Review
Zheng et al., Guangzhou, China. In Int J Cancer, 2012
XPA, a zinc-finger DNA-binding protein, play an important role in both global genome and transcription-coupled repair pathways.
Identification of a functional estrogen-responsive enhancer element in the promoter 2 of PRDM2 gene in breast cancer cell lines.
GeneRIF
Puca et al., Napoli, Italy. In J Cell Physiol, 2012
Acting as a negative regulator of RIZ1 function, PRFM2 mediates effect of cell proliferation by estrogen via regulation of cell survival and differentiating gene expression.
Study on RIZ1 gene promoter methylation status in human esophageal squamous cell carcinoma.
GeneRIF
Wang et al., Tianjin, China. In World J Gastroenterol, 2012
Data suggest that promoter methylation may play an important role in the epigenetic silencing of RIZ1 gene expression in human esophageal squamous cell carcinoma.
Decreased expression of retinoblastoma protein-interacting zinc-finger gene 1 in human esophageal squamous cell cancer by DNA methylation.
GeneRIF
Zhang et al., Tianjin, China. In Clin Lab, 2011
RIZ1 may be a potential tumor suppressor in human esophageal squamous cell cancer.
Anticancer activity of the PR domain of tumor suppressor RIZ1.
GeneRIF
Yang et al., Saskatoon, Canada. In Int J Med Sci, 2010
RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.
Brown fat biology and thermogenesis.
Review
Picard et al., Québec, Canada. In Front Biosci, 2010
Brown adipocyte (trans)differentiation depends on various receptors / transcription factors that include peroxisome proliferator-activated receptor g (PPARgamma), PPARgamma-coactivator-1alpha (PGC1alpha), PRD1-BF1-RIZ1 homologous domain-containing 16 (PRDM16), CCAAT/enhancer-binding protein beta (C/EBP-beta) and bone morphogenetic protein 7 (BMP7).
Suppression of RIZ in biologically unfavourable neuroblastomas.
GeneRIF
Larsson et al., Stockholm, Sweden. In Int J Oncol, 2010
RIZ1 promoter methylation is not a common event in neuroblastoma.
PRDM16 controls a brown fat/skeletal muscle switch.
Impact
Spiegelman et al., Boston, United States. In Nature, 2008
We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain.
Impact
Hill et al., Edinburgh, United Kingdom. In Nature, 1989
Neuromeres in the hindbrain (rhombomeres) have been defined as segmental units by their pattern of nerve formation in the developing chick and by the alternating expression of Krox-20, a gene encoding a zinc-finger DNA-binding protein, in the 9.5-day-old mouse.
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