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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger protein 331

RITA, KRAB zinc finger protein
This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. A pseudogene of this gene is located on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: p53, CAN, mdm2, V1a, NGF
Papers using RITA antibodies
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
Supplier
Santos Janine, In PLoS ONE, 2009
... RITA was purchased from Cayman Chemical (Cayman Europe, Tallinn, ...
HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells.
Supplier
Speck Roberto F., In PLoS ONE, 2006
... Blocking antibodies against Siglec-1 and Siglec-9 (sheep polyclonal) were prepared by Rita Sharma in the Crocker laboratory; mouse monoclonal anti-human Siglec-3 (clone 6C5/2) was obtained from Abcam (Cambridge, MA) ...
Papers on RITA
CRISPR-Cas9-based target validation for p53-reactivating model compounds.
New
Stiewe et al., Marburg an der Lahn, Germany. In Nat Chem Biol, Jan 2016
In contrast, sensitivity to the drug RITA, which binds the Mdm2-interacting N terminus of p53, correlates with induction of DNA damage.
Temporary Immersion Bioreactors for the Contained Production of Recombinant Proteins in Transplastomic Plants.
New
Nixon et al., Fontaine, France. In Methods Mol Biol, Dec 2015
This method describes the organogenesis of transplastomic Nicotiana tabacum callus in RITA(®) temporary immersion bioreactors to produce rootless leafy biomass, and subsequent total soluble protein extraction, SDS-PAGE, and Western immunoblot analysis of heterologous protein expression.
RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.
New
Pei et al., Changsha, China. In Oncol Rep, Sep 2015
A recent study demonstrated that small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) increased the radiosensitivity of tumor cells expressing mutant p53 (mtp53).
NGF/TrkA Signaling as a Therapeutic Target for Pain.
Review
New
Murata et al., Japan. In Pain Pract, Sep 2015
UNASSIGNED: Nerve growth factor (NGF) was first discovered approximately 60 years ago by Rita Levi-Montalcini as a protein that induces the growth of nerves.
Proteomic profiling of white muscle from freshwater catfish Rita rita.
New
Mohanty et al., Calcutta, India. In Fish Physiol Biochem, Jun 2015
The freshwater catfish Rita rita of the family Bagridae inhabiting the tropical rivers and estuaries is an important food fish with high nutritive value and is also considered a species of choice in riverine pollution monitoring.
The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses.
New
Macfarlan et al., Bethesda, United States. In Genes Dev, Apr 2015
Retroviruses have been invading mammalian germlines for millions of years, accumulating in the form of endogenous retroviruses (ERVs) that account for nearly one-tenth of the mouse and human genomes.
Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer.
New
Brown et al., Australia. In Cancer Res, Mar 2015
Stabilization of p53 with RITA leads to a significant decrease in the PGE2-stimulated aromatase mRNA expression and activity, and PII activity.
The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors.
Barran et al., Edinburgh, United Kingdom. In Front Mol Biosci, 2014
Here we demonstrate the use of IM-MS to characterize the effect of two inhibitors RITA and Nutlin-3 on their respective binding partners: p53 and MDM2.
p53 Family and Cellular Stress Responses in Cancer.
Review
Müller et al., Regensburg, Germany. In Front Oncol, 2013
Small molecules (e.g., Nutlins, RITA, PRIMA-1, and MIRA-1 among others) have been objects of intense research interest in recent years.
The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012).
Review
Chaldakov et al., Roma, Italy. In Balkan Med J, 2013
The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM) discovering the nerve growth factor (NGF).
Targeting p53 by small molecules in hematological malignancies.
Review
Chang et al., Toronto, Canada. In J Hematol Oncol, 2012
Small molecules such as nutlin, RITA, and PRIMA-1 that can activate p53 have shown their anti-tumor effects in different types of hematological malignancies.
The metabotrophic NGF and BDNF: an emerging concept.
Review
Chaldakov, Varna, Bulgaria. In Arch Ital Biol, 2011
There is evidence now that NGF and BDNF mediate multiple biological phenomena, ranging from the Rita Levi Montalcini's neurotrophic through immunotrophic to epitheliotrophic and nociceptive effects.
Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis.
Impact
Selivanova et al., Stockholm, Sweden. In Cancer Cell, 2009
We report a potent inhibition of crucial oncogenes by p53 upon reactivation by small-molecule RITA in vitro and in vivo.
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53.
Impact
Selivanova et al., Stockholm, Sweden. In Cancer Cell, 2009
We have previously identified the p53-reactivating compound RITA in a cell-based screen.
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
Impact
Selivanova et al., Stockholm, Sweden. In Nat Med, 2004
We have screened a chemical library and identified a small molecule named RITA (reactivation of p53 and induction of tumor cell apoptosis), which bound to p53 and induced its accumulation in tumor cells.
A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas.
GeneRIF
Bullerdiek et al., Bremen, Germany. In Cytogenet Genome Res, 2002
Unique expression of a 3.4-kbp transcript of ZNF331 is described in thyroid adenoma cell lines with 19q13 aberrations.
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