RISC assembly: Coordination between small RNAs and Argonaute proteins.
Tokyo, Japan. In Biochim Biophys Acta, Jan 2016
Small RNAs, including microRNAs, small interfering RNAs, and PIWI-interacting RNAs, assemble with Argonaute (Ago) family proteins into the effector complex called RNA-induced silencing complex (RISC), which mediates sequence-specific target gene silencing.
Exosome mediated communication within the tumor microenvironment.
Boston, United States. In J Control Release, Jan 2016
An illustrative distinction is that exosomes derived from cancer cells contain more microRNA than healthy cells and unlike exosomes released from healthy cells, this microRNA can be associated with the RNA-induced silencing complex (RISC) which is required for processing mature and biologically active microRNA.
[MicroRNAs: what cardiologists should know about them?].
Paris, France. In Presse Med, Jul 2015
MiRNAs are small 21-22 nucleotides long RNAs transcribed from non coding genes or introns of coding genes that are involved the repression of cellular messenger RNAs by the RISC complex.
MicroRNA Processing and Human Cancer.
Houston, United States. In J Clin Med, 2014
As previous studies have shown, the sequential miRNA processing can be divided into three steps: processing by RNAse in the nucleus; transportation by Exportin-5 (XPO5) from the nucleus; and processing by the RNA-induced silencing complex (RISC) in the cytoplasm.