The serine threonine kinase RIP3: lost and found.
Aurora, United States. In Bmb Rep, Jun 2015
Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential protein in the "programmed", or "regulated" necrosis cell death pathway that is activated in response to death receptor ligands and other types of cellular stress.
Necroptosis, in vivo detection in experimental disease models.
Gent, Belgium. In Semin Cell Dev Biol, 2014
Initially, Receptor-Interacting Protein Kinase 1 (RIPK1) and RIPK3 kinase activity were uniquely associated with induction of necroptosis, however recent evidence suggests pleiotropic functions in cell death, inflammation and survival, obscuring a clear picture.