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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RIO kinase 3

RIOK3, SudD
This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, MDA5, p21, fibrillin-1, SCAD
Papers on RIOK3
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.
New
Harris et al., Stockholm, Sweden. In Oncogene, Oct 2015
We demonstrate that expression of RIOK3 (RIght Open reading frame kinase 3) was increased during hypoxic exposure in an HIF1α-dependent manner.
RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.
New
Seya et al., In Cell Rep, May 2015
Here, we identified RIO kinase 3 (RIOK3) as a protein kinase that phosphorylates the MDA5 C-terminal region.
Moderate to severe and prolonged left lower-abdominal pain is the best symptom characterizing symptomatic uncomplicated diverticular disease of the colon: a comparison with fecal calprotectin in clinical setting.
New
Brandimarte et al., Roma, Italy. In J Clin Gastroenterol, Mar 2015
BACKGROUND: Left lower-abdominal pain is considered the best symptom to differentiate between symptomatic uncomplicated diverticular disease (SUDD) and irritable bowel syndrome (IBS).
Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population.
Wallaschofski et al., Greifswald, Germany. In Plos One, 2014
RESULTS: In men, positive correlations were detected between AD and DDIT4 mRNA levels, as well as between SHBG and the mRNA levels of RPIA, RIOK3, GYPB, BPGM, and RAB2B.
RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.
Sun et al., Los Angeles, United States. In J Virol, 2014
We report here the identification of RIOK3 as a novel adaptor protein that is essential for the cytosolic nucleic acid-induced type I IFN production and for the antiviral response to gammaherpesvirus through two independent kinome-wide RNA interference screens.
RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling.
Lauth et al., Marburg an der Lahn, Germany. In Cell Signal, 2013
Performing a multi-well kinase screen in human cells identified RIO kinase 3 (RIOK3) as a novel modulator of SUFU subcellular distribution.
Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor-alpha in diverticular disease of the colon: a case-control study.
Ierardi et al., Andria, Italy. In Neurogastroenterol Motil, 2012
METHODS: Fifteen patients affected by AUD and seven patients affected by symptomatic uncomplicated diverticular disease (SUDD) were enrolled.
Musosal tumour necrosis factor α in diverticular disease of the colon is overexpressed with disease severity.
Ierardi et al., Andria, Italy. In Colorectal Dis, 2012
METHOD: Twenty-four patients with symptomatic DD were divided into those with acute uncomplicated diverticulitis (AUD) (12 patients) and those with symptomatic uncomplicated diverticular disease (SUDD) (12 patients).
Human RioK3 is a novel component of cytoplasmic pre-40S pre-ribosomal particles.
GeneRIF
Mougin et al., Toulouse, France. In Rna Biol, 2012
RioK3 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA.
Biomarkers in diverticular diseases of the colon.
Review
Tursi, Andria, Italy. In Dig Dis, 2011
In particular, FC may show slight increased valued already in symptomatic uncomplicated DD (SUDD) (FC value ≥15 μg/ml seems to be predictive of SUDD).
Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells.
Vadgama et al., Los Angeles, United States. In Mol Cancer Ther, 2010
In addition, promoter methylation was detected for the first time in target genes such as RIOK3, STAT5, CASP8, SRBC, GAGE1, and NPAT.
Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung.
Yekebas et al., Hamburg, Germany. In Bmc Cancer, 2009
Numerous genes were overexpressed, some of which have previously been implicated in pancreatic adenocarcinoma (GATA6, IGFBP3, IGFBP6), while others were detected for the first time (MEMO1, RIOK3).
RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway.
Huo et al., Shanghai, China. In Mol Cell Biochem, 2009
RIOK3 was initially characterized as a homolog of Aspergillus nidulans sudD and showed down-regulation at the invasive front of malignant melanomas, but the molecular mechanism remains elusive.
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
GeneRIF
DePinho et al., Boston, United States. In Proc Natl Acad Sci U S A, 2009
Like RIOK3, PAK4 promotes pancreas ductal cell motility and invasion in pancreatic cancer
Discrimination between gene expression patterns in the invasive margin and the tumour core of malignant melanomas.
Becker et al., Regensburg, Germany. In Melanoma Res, 2003
The gene encoding phosphoenolpyruvate carboxykinase 1 (PEPCK), the Homo sapiens gene similar to Saccharomyces cerevisiae SSM4 (TEB4), the gene encoding ribosomal protein L19, the Homo sapiens gene similar to the Aspergillus nidulans SudD (a suppressor of the bimD6 homologue), the gene encoding the interleukin-3 receptor alpha subunit, the gene encoding the inositol 1,4,5-triphosphate 3-kinase isoenzyme, and three anonymous expressed sequence tags were identified as class-separating genes.
Isolation of the Aspergillus nidulans sudD gene and its human homologue.
May et al., Houston, United States. In Gene, 1998
We have now cloned the sudD gene, another of the extragenic suppressor genes of the bimD6 mutation.
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