A Genome-wide Scan for Selective Sweeps in Racing Horses.
Seoul, South Korea. In Asian-australas J Anim Sci, Nov 2015
Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2) genes have similar roles in signal trafficking, suggesting that a co-evolving gene cluster located on the chromosome 22 is under strong artificial selection in racehorses.
A tale of three GTPases and a RIN in endothelial cell adhesion.
Amsterdam, Netherlands. In Cell Res, 2012
In a paper recently published in Cell Research, Sandri et al. show that RIN2 connects three GTPases, R-Ras, Rab5 and Rac1, to promote endothelial cell adhesion through the regulation of integrin internalization and Rac1 activation.