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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ras and Rab interactor 1

RIN1, Eri1
may act as a regulator of Ras-mediated signal transduction [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ABL, Rab5, CAN, Raf, BCR
Papers using RIN1 antibodies
A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1
Supplier
Colicelli J et al., In Leukemia, 1994
... The RIN1-silencing short hairpin RNA (shRNA) lentivirus in the pLKO.1-puro
Papers on RIN1
Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up.
New
Cheong et al., Suwŏn, South Korea. In Dna Cell Biol, Jan 2016
Integrative analysis revealed that the overexpression of 16 genes, including FGR (p = 0.003), RELA (p = 0.049), LTBP3 (p = 0.050), and RIN1 (p = 0.023), was significantly associated with shorter time to tumor recurrence.
ABL SH3 mutant inhibits BCR-ABL activity and increases imatinib sensitivity by targeting RIN1 protein in CML cell.
New
Feng et al., Chongqing, China. In Cancer Lett, Jan 2016
RIN1 interacts with BCR-ABL SH3 domain via PxxP motifs to promote autophosphorylation as well as activation of BCR-ABL tyrosine kinase, suggesting using exogenous SH3 domain which blocks the interaction of BCR-ABL and RIN1 could be an adjunct therapy for CML.
Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
New
Colicelli et al., Los Angeles, United States. In Faseb J, Sep 2015
The RAS effector RAS- and RAB-interacting protein 1 (RIN1) activates its own downstream effectors, the small GTPase RAB5 and the tyrosine kinase Abelson tyrosine-protein kinase (ABL), to modulate endocytosis and cytoskeleton remodeling.
Inverse regulation of bridging integrator 1 and BCR-ABL1 in chronic myeloid leukemia.
New
Musto et al., Prato, Italy. In Tumour Biol, Aug 2015
Rab interactor 1 (RIN1), an activator of BIN1, displayed a similar behavior.
The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
New
Khew-Goodall et al., Adelaide, Australia. In Sci Signal, Mar 2015
We identified RIN1 (Ras and Rab interactor 1) and PRKCD (protein kinase C-δ) as binding partners and substrates of PTPN14.
Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.
Colicelli et al., Jupiter, United States. In Plos One, 2014
We developed a time-resolved Förster resonance energy transfer (TR-FRET) -based assay to identify compounds that disrupt stimulation of the ABL kinase by blocking its ability to bind the positive regulator RIN1.
A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma.
Luo et al., Xinhui, China. In Nat Commun, 2014
Moreover, methylation at the five CpGs correlates with expression of five genes: PITX1, FOXE3, TWF2, EHBP1L1 and RIN1.
Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye.
Review
Heissmeyer et al., München, Germany. In Wiley Interdiscip Rev Rna, 2014
Such 3' oligouridylated transcripts are preferentially bound by the heteroheptameric LSM1-7 complex, which also interacts with the 3'→5' exonuclease ERI1 (also called 3'hExo).
Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.
Review
Ansel et al., San Francisco, United States. In Trends Genet, 2014
Eri1 is an evolutionarily conserved 3'-5' exoribonuclease that participates in 5.8S rRNA 3' end processing and turnover of replication-dependent histone mRNAs.
Proteomic profile and in silico analysis in metastatic melanoma with and without BRAF mutation.
Stefania et al., Bari, Italy. In Plos One, 2013
Proteins associated with the modulation of neuronal plasticity (RIN1) and regulatory activity factors of gene transcription (KLF17, ZBTB44) were also highlighted.
Overexpression of RIN1 associates with tumor grade and progression in patients of bladder urothelial carcinoma.
GeneRIF
Kong et al., Shenyang, China. In Tumour Biol, 2012
RIN1 expression could be a potential prognostic predictor for bladder urothelial carcinoma (UC) patients.
A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration.
GeneRIF
Hausser et al., Tübingen, Germany. In Mol Biol Cell, 2011
These data identify a novel PKD signaling pathway through RIN1 and Abl kinases that is involved in the regulation of actin remodeling and cell migration.
ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.
GeneRIF
Colicelli et al., Los Angeles, United States. In Leukemia, 2011
BCR-ABL1 kinase activity is regulated by RIN1
Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling.
GeneRIF
Colicelli et al., Los Angeles, United States. In J Neurosci Res, 2010
This study provided evidence that Rin1 normally functions as a negative regulator of fear learning and memory (Rin1-/- mice have enhanced fear conditioning and diminished fear extinction).
Regulated expression of the Ras effector Rin1 in forebrain neurons.
GeneRIF
Colicelli et al., Los Angeles, United States. In Mol Cell Neurosci, 2010
These results provide insight into regulated expression of Rin1, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons.
Molecular biology: silencing unlimited.
Review
Allshire et al., Edinburgh, United Kingdom. In Curr Biol, 2006
The Eri1 ribonuclease is a negative regulator of the RNA interference machinery; recent studies have shown that, in fission yeast lacking Eri1, heterochromatin formation is more promiscuous.
Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing.
Impact
Moazed et al., Boston, United States. In Cell, 2006
Furthermore, the ability of the newly generated ura4+ siRNAs to silence a second ura4+ allele in trans is strongly inhibited by the conserved siRNA nuclease, Eri1.
Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.
Impact
Levin et al., Baltimore, United States. In Cell, 2004
The yeast ERI1 gene encodes a small ER-localized protein that associates in vivo with GTP bound Ras2 in an effector loop-dependent manner.
Molecular biology of chronic myeloid leukemia.
Review
Maru, Tokyo, Japan. In Int J Hematol, 2001
Domains in BCR and ABL sequences work in concert to elicit a variety of leukemogenic signals including Ras, STAT5 (signal transducer and activator of transcription-5), Myc, cyclin D1, P13 (phosphatidylinositol 3-kinase), RIN1 (Ras interaction/interference), and activation of actin cytoskeleton.
Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.
Impact
Colicelli et al., Los Angeles, United States. In Immunity, 1997
RIN1 was originally identified by its ability to physically bind to and interfere with activated Ras in yeast.
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