RIM proteins and their role in synapse function.
Bonn, Germany. In Biol Chem, 2010
The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins.
The synaptic vesicle cycle.
Dallas, United States. In Annu Rev Neurosci, 2003
In particular, insight into how Munc18-1 collaborates with SNARE proteins in fusion, how the vesicular Ca2+ sensor synaptotagmin 1 triggers fast release, and how the vesicular Rab3 protein regulates release by binding to the active zone proteins RIM1 alpha and RIM2 alpha has advanced our understanding of neurotransmitter release.
cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
Chiba, Japan. In Nat Cell Biol, 2000
Here we show that cAMP-GEFII, a cAMP sensor, binds to Rim (Rab3-interacting molecule, Rab3 being a small G protein) and to a new isoform, Rim2, both of which are putative regulators of fusion of vesicles to the plasma membrane.