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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulating synaptic membrane exocytosis 2

RIM2, RIMS2, Rim2p
synaptic protein important for normal neurotransmitter release; binds Rab3a [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rab3A, RIM1, CAN, Insulin, OUT
Papers using RIM2 antibodies
Molecular dissection of the photoreceptor ribbon synapse
Brandstätter Johann H. et al., In The Journal of Cell Biology, 1996
... Biosciences), mouse anti-RIM mAb (WB 1:1,000; BD Biosciences), rabbit anti-RIM1 (post-EM 1:50; IHC 1:500) and anti-RIM2 pAbs (IHC 1:500; Synaptic Systems GmbH), rabbit anti-synaptojanin pAb ...
Papers on RIM2
RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.
Schmitz et al., Homburg, Germany. In J Neurosci, Oct 2015
The conditional double knock-out (cdko) of RIM1 and RIM2 from rods starting a few weeks after birth did not change Cav1.4 protein expression at rod ribbon synapses nor was the morphology of the ribbon altered.
Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.
Moser et al., Göttingen, Germany. In Proc Natl Acad Sci U S A, Jul 2015
Hair cell-specific deletion of all RIM2 isoforms caused a stronger reduction of Ca(2+) influx and exocytosis and significantly impaired the encoding of sound onset in the postsynaptic spiral ganglion neurons.
Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.
Ptáček et al., Münster, Germany. In Proc Natl Acad Sci U S A, Apr 2015
Here, we show that PNKD interacts with synaptic active zone proteins Rab3-interacting molecule (RIM)1 and RIM2, localizes to synapses, and modulates neurotransmitter release.
RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.
Schneggenburger et al., Lausanne, Switzerland. In J Neurophysiol, 2015
The long isoforms of RIM proteins, which contain NH2-terminal Rab3- and Munc13-interacting domains, as well as a central PDZ domain and two COOH-terminal C2 domains, are encoded by two genes, Rim1 and Rim2.
[Contribution of synaptic release mechanisms to the building of sensory maps].
Rebsam et al., Paris, France. In Biol Aujourdhui, 2014
Conditional knockout of the Rim1 and Rim2 genes allowed to interrogate more specifically the role of calcium-triggered release.
The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters.
Palmieri et al., Potenza, Italy. In J Biol Chem, 2014
In confirmation of their identity (i) SLC25A33 and SLC25A36 were found to be targeted to mitochondria and (ii) the phenotypes of Saccharomyces cerevisiae cells lacking RIM2, the gene encoding the well characterized yeast mitochondrial pyrimidine nucleotide carrier, were overcome by expressing SLC25A33 or SLC25A36 in these cells.
Effect of cannabinoid receptors 1 modulation on osteoporosis in a rat model of different ages.
Malek et al., Al Manşūrah, Egypt. In J Physiol Pharmacol, 2014
Each main group subdivided into four subgroups as follows: (NC1) and (NC2), the negative control groups, (MP1) and (MP2), received methylprednisolone (glucocorticoid), (RIM1) and (RIM2), received rimonabant, (MP + RIM1) and (MP + RIM2) received methylprednisolone with rimonabant.
Case of the weeping wound: formation of a lacrimal pseudocyst following lateral canthal surgery.
Shriver et al., Iowa City, United States. In Ophthal Plast Reconstr Surg, 2014
An 87-year-old woman presented with a subcutaneous fluid collection overlying the right lateral orbital rim 2 days after undergoing a lateral tarsal strip.
Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter.
Costa et al., In J Biol Chem, 2014
The CG18317 gene (drim2) is the Drosophila melanogaster homolog of the Saccharomyces cerevisiae Rim2 gene, which encodes a pyrimidine (deoxy)nucleotide carrier.
The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron.
Wiesenberger et al., Vienna, Austria. In Biochem J, 2013
In Saccharomyces cerevisiae, overexpression of RIM2 (MRS12) encoding a mitochondrial pyrimidine nucleotide transporter can overcome the iron-related phenotypes of strains lacking both MRS3 and MRS4.
Association between regulating synaptic membrane exocytosis 2 gene polymorphisms and degenerative lumbar scoliosis.
Chung et al., Seoul, South Korea. In Biomed Rep, 2013
The purpose of this study was to investigate the association between regulating synaptic membrane exocytosis 2 (RIMS2, OBOE) gene polymorphisms and DLS.
Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear.
Brandstätter et al., Erlangen, Germany. In Plos One, 2012
With in situ proximity ligation assays we provide evidence that this truncation leads to the absence of interaction sites for Bassoon, Munc13, and presumably also ELKS/CAST, RIM2, and the L-type Ca(2) (+) channel which exist in the full-length Piccolo at active zones of conventional chemical synapses.
RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
Michaut et al., Argentina. In Exp Cell Res, 2012
Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria.
Dancis et al., Philadelphia, United States. In Biochem J, 2011
Rim2 is a pyrimidine exchanger with an additional unique function in promoting mitochondrial iron utilization
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone.
Schneggenburger et al., Lausanne, Switzerland. In Neuron, 2011
Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2)+ channel density and vesicle docking at the active zone.
Rim2alpha determines docking and priming states in insulin granule exocytosis.
Seino et al., Kōbe, Japan. In Cell Metab, 2010
Rim2alpha determines docking and priming states in insulin granule exocytosis depending on its interacting partner, Rab3A or Munc13-1, respectively.
Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule.
Striessnig et al., Innsbruck, Austria. In Mol Cell Neurosci, 2010
These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 gating kinetics in immature cochlear inner hair cells.
RIM proteins and their role in synapse function.
Schoch et al., Bonn, Germany. In Biol Chem, 2010
The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins.
The synaptic vesicle cycle.
Sudhof, Dallas, United States. In Annu Rev Neurosci, 2003
In particular, insight into how Munc18-1 collaborates with SNARE proteins in fusion, how the vesicular Ca2+ sensor synaptotagmin 1 triggers fast release, and how the vesicular Rab3 protein regulates release by binding to the active zone proteins RIM1 alpha and RIM2 alpha has advanced our understanding of neurotransmitter release.
cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
Seino et al., Chiba, Japan. In Nat Cell Biol, 2000
Here we show that cAMP-GEFII, a cAMP sensor, binds to Rim (Rab3-interacting molecule, Rab3 being a small G protein) and to a new isoform, Rim2, both of which are putative regulators of fusion of vesicles to the plasma membrane.
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