gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulating synaptic membrane exocytosis 1

RIM1, RIM1alpha, Rab3 effector, CORD7
The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: Rab3A, Munc13, V1a, CAN, ACID
Papers on RIM1
RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.
Schmitz et al., Homburg, Germany. In J Neurosci, Oct 2015
Here, we show that active zone proteins RIM1/2 are important regulators of Cav1.4 channel function in mouse rod photoreceptors and thus synaptic activity.
Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.
Ptáček et al., Münster, Germany. In Proc Natl Acad Sci U S A, Apr 2015
Here, we show that PNKD interacts with synaptic active zone proteins Rab3-interacting molecule (RIM)1 and RIM2, localizes to synapses, and modulates neurotransmitter release.
RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.
Schneggenburger et al., Lausanne, Switzerland. In J Neurophysiol, 2015
The long isoforms of RIM proteins, which contain NH2-terminal Rab3- and Munc13-interacting domains, as well as a central PDZ domain and two COOH-terminal C2 domains, are encoded by two genes, Rim1 and Rim2.
Effect of cannabinoid receptors 1 modulation on osteoporosis in a rat model of different ages.
Malek et al., Al Manşūrah, Egypt. In J Physiol Pharmacol, 2014
Each main group subdivided into four subgroups as follows: (NC1) and (NC2), the negative control groups, (MP1) and (MP2), received methylprednisolone (glucocorticoid), (RIM1) and (RIM2), received rimonabant, (MP + RIM1) and (MP + RIM2) received methylprednisolone with rimonabant.
Differential synaptic distribution of the scaffold proteins Cask and Caskin1 in the bovine retina.
Schmitz et al., Homburg, Germany. In Mol Cell Neurosci, 2014
Cask was localized in close vicinity to the active zone protein RIM1/2 in ribbon and conventional synapses.
The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus.
Schoch et al., Bonn, Germany. In J Neurosci, 2012
Presynaptic plasticity and function of RIM1a play an important part in the neuron's adaptive response to aberrant electrical activity following pharmacologically induced status epielepticus.
RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
Michaut et al., Argentina. In Exp Cell Res, 2012
Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
Munc13-1 is required for presynaptic long-term potentiation.
Calakos et al., Durham, United States. In J Neurosci, 2011
The interaction between RIM1alpha and Munc13-1 is required for presynaptic long-term plasticity
Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
Kilimann et al., Uppsala, Sweden. In Proc Natl Acad Sci U S A, 2011
Data show that Bassoon colocalizes with Aczonin at conventional synapses, but in ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, and Aczonin is positioned and may control the access of neurotransmitter vesicles to the fusion site.
[Molecular mechanism at the presynaptic active zone].
Ohtsuka, Japan. In Brain Nerve, 2011
Presently, the full molecular composition of AZ is unclear, but it is known to contain several AZ-specific proteins, including cytomatrix of the active zone-associated protein (CAST)/ERC2, ELKS, RIM1, Munc13-1, Piccolo/Aczonin, and Bassoon.
Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release.
Felix et al., Mexico. In J Biol Chem, 2011
a novel functional coupling between RIM1 and the L-type Ca(V) channels via the Ca(V)beta auxiliary subunit that contribute to determine insulin secretion.
CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone.
Ohtsuka et al., Japan. In J Biochem, 2010
They have been shown to directly interact with other AZ proteins, including RIM1, Piccolo and Bassoon, and indirectly with Munc13-1 through RIM1, forming a large molecular complex at AZ.
RIM proteins and their role in synapse function.
Schoch et al., Bonn, Germany. In Biol Chem, 2010
The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins.
KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.
Hirokawa et al., Tokyo, Japan. In Nat Cell Biol, 2008
We also show that DENN/MADD binds preferentially to GTP-Rab3 and acts as a Rab3 effector.
A fight for neurotransmission: SCRAPPER trashes RIM.
Craig et al., Vancouver, Canada. In Cell, 2007
The presynaptic scaffold molecule RIM1alpha is important for regulating neurotransmitter release.
SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.
Setou et al., Machida, Japan. In Cell, 2007
Proteasome-mediated regulation of RIM1 and synaptic transmission is mediated by SCRAPPER (synapse localized E3 ubiquitin ligase).
Molecular organization and assembly of the presynaptic active zone of neurotransmitter release.
Gundelfinger et al., Magdeburg, Germany. In Results Probl Cell Differ, 2005
These include the multi-domain Rab3-effector proteins RIM1alpha and RIM2alpha; Bassoon and Piccolo, two multi-domain CAZ scaffolding proteins of enormous size; as well as members of the CAST/ERC family of CAZ-specific structural proteins.
RIM function in short- and long-term synaptic plasticity.
Südhof et al., Dallas, United States. In Biochem Soc Trans, 2005
RIM1alpha (Rab3-interacting molecule 1alpha) is a large multidomain protein that is localized to presynaptic active zones [Wang, Okamoto, Schmitz, Hofmann and Südhof (1997) Nature (London) 388, 593-598] and is the founding member of the RIM protein family that also includes RIM2alpha, 2beta, 2gamma, 3gamma and 4gamma [Wang and Südhof (2003) Genomics 81, 126-137].
The synaptic vesicle cycle.
Sudhof, Dallas, United States. In Annu Rev Neurosci, 2003
In particular, insight into how Munc18-1 collaborates with SNARE proteins in fusion, how the vesicular Ca2+ sensor synaptotagmin 1 triggers fast release, and how the vesicular Rab3 protein regulates release by binding to the active zone proteins RIM1 alpha and RIM2 alpha has advanced our understanding of neurotransmitter release.
Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses.
Linden et al., Dallas, United States. In Cell, 2003
Results suggest that protein kinase A-mediated phosphorylation of the active zone protein RIM1alpha at a single N-terminal site induces presynaptic long-term potentiation.
share on facebooktweetadd +1mail to friends