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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PDZ and LIM domain 4

binds alpha-actinin; may regulate actin stress fiber turnover [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, HAD, Interleukin-2, IFN-gamma, IL-12
Papers using rIL antibodies
Frontal–subcortical protein expression following prenatal exposure to maternal inflammation
Mirnics K et al., In Translational Psychiatry, 2010
... For rIL-6 injections, 5 μg carrier-free, mouse rIL-6 (eBioscience, San Diego, CA, USA) ...
miRBase: tools for microRNA genomics.
Unutmaz Derya, In PLoS ONE, 2007
... rIL-15 was purchased from R&D and rIL-2 from eBioscience (San Diego, CA) ...
enoLOGOS: a versatile web tool for energy normalized sequence logos.
Smith Joe D., In PLoS Pathogens, 2004
... Proteins were expressed in BL21-CodonPlus(DE3)-RIL cells (Stratagene) with 0.2 mM IPTG at room temperature and affinity purified using glutathione resin (Clontech).
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Behar Samuel M. et al., In The Journal of Experimental Medicine, 2004
... inhibitor VI (Z-YVAD-Fmk; 218746; Calbiochem), caspase inhibitor negative control (Z-FA-Fmk; 342000; Calbiochem), recombinant mouse IL-1β (rIL-1β; R&D Systems), anti–IL-1β (B122; eBioscience), Armenian hamster IgG (eBio299Arm; ...
The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain
Takata Kuniaki et al., In Acta Histochemica et Cytochemica, 2003
... ]; goat anti-RIL antibody raised against C-terminal amino acids of rat RIL (Abcam, Cambridge, UK); mouse anti-glial ...
Papers on rIL
Beneficial effects of IL-37 after spinal cord injury in mice.
López-Vales et al., Barcelona, Spain. In Proc Natl Acad Sci U S A, Feb 2016
In the present study, we subjected mice transgenic for human IL-37 (hIL-37tg) and wild-type (WT) mice to spinal cord contusion injury and then treated them with recombinant human IL-37 (rIL-37).
Melanoma immunotherapy in mice using genetically engineered pluripotent stem cells.
Song et al., In Cell Transplant, Feb 2016
The gene-transduced iPSCs were cultured on the delta-like ligand 1-expressing OP9 (OP9-DL1) murine stromal cells in the presence of murine recombinant cytokines (rFlt3L and rIL-7) for a week.
Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells.
Wang et al., Shenyang, China. In Bosn J Basic Med Sci, Feb 2016
E. coli RNA-stimulated transforming growth factor beta 1 (TGF-β1) overproduction in HSC-T6 cells, which was blocked by recombinant IL-1 receptor antagonist (rIL-1Ra) or nuclear factor κB inhibitor BAY 11-7082.
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.
Rafei et al., Montréal, Canada. In Aging Cell, Feb 2016
In sharp contrast, no alterations in the frequency of bone marrow (BM)-derived progenitors were detected following rIL-21 administration.
IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-α-induced apoptosis in steroid-induced osteonecrosis.
Ye et al., Wuhan, China. In Osteoporos Int, Feb 2016
The mice in group MI received intra-abdominal injections of 2 μg/100 g/day of rIL-4 for five consecutive days, following the administration of MPS.
Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy.
Wakeford et al., Toronto, Canada. In Cochrane Database Syst Rev, 2014
We did find evidence of an increase in skin rash (erlotinib: RR 6.57; 95% CI 3.60 to 12.00; 191 participants, one study; lapatinib: RR 2.02; 95% CI 1.23 to 3.32; 67 participants, one study) and gastrointestinal complaints (lapatinib: RR 15.53; 95% CI 2.18 to 110.55; 67 participants, one study).We found very low quality evidence from one small trial that adding recombinant interleukin (rIL-2) to surgery may increase overall survival (HR 0.52; 95% CI 0.31 to 0.87; 201 participants, 62% oral cavity tumours, 38% oropharyngeal tumours) and there was insufficient evidence to determine whether rIL-2 impacts on adverse effects.
Specific expression and activity of acid phosphatases in common bean nodules.
Drevon et al., Sweden. In Plant Signal Behav, 2013
Under P-deficiency, this positive correlation was more significant for the recombinant inbred line (RIL) of Phaseolus vulgaris RIL115 that is tolerant to P-deficiency than the sensitive RIL147.
Advances in antiretroviral therapy.
Eron et al., Madrid, Spain. In Curr Opin Hiv Aids, 2013
RECENT FINDINGS: In the last 2 years, clinical trials have demonstrated the safety and efficacy of three integrase transfer inhibitors [raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG)], one new nonnucleoside reverse transcriptase inhibitor [rilpivirine (RIL)] and a new extended release formulation of nevirapine in antiretroviral-naive and experienced patients.
CLP36 and RIL recruit α-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts.
Sato et al., Hamamatsu, Japan. In Exp Cell Res, 2012
The RIL has a redundant role in the formation of stress fibers, but have different effects on stress fiber dynamics in F2408 cells.
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Kupper et al., Boston, United States. In Nat Med, 2012
Il9r(-/-) mice showed accelerated tumor growth, and administration of recombinant IL-9 (rIL-9) to tumor-bearing WT and Rag1(-/-) mice inhibited melanoma as well as lung carcinoma growth.
Structural basis for allosteric regulation of GPCRs by sodium ions.
Stevens et al., Los Angeles, United States. In Science, 2012
We reengineered the human A(2A) adenosine receptor by replacing its third intracellular loop with apocytochrome b(562)RIL and solved the structure at 1.8 angstrom resolution.
The role of IL-21 in hematological malignancies.
Ji et al., Jinan, China. In Cytokine, 2011
Conducted phase I trials in metastatic malignant melanoma and renal cell carcinoma have shown that rIL-21 has a favorable antitumor activity.
Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein.
Chumakov et al., Cleveland, United States. In J Biol Chem, 2011
Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein.
Immunotherapies in HIV-1 infection.
Pett, Australia. In Curr Opin Hiv Aids, 2009
This review is timely, as the results of the phase III clinical trials of recombinant interleukin-2 (rIL-2) as adjuncts to combination antiretroviral therapy are about to be released.
Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle.
Wu et al., Pittsburgh, United States. In J Cell Biol, 2009
Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle.
PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.
Young et al., Rochester, United States. In Cancer Invest, 2009
PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells.
Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin.
O'Connor et al., Galveston, United States. In J Biol Chem, 2009
several genes that are known to be regulated by DNA methylation were up-regulated dramatically by integrin alpha6beta4 expression, including S100A4, FST, PDLIM4, CAPG, and Nkx2.2.
Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma.
Hausman et al., Seattle, United States. In J Clin Oncol, 2008
PURPOSE: A phase I study of patients with metastatic malignant melanoma (MM) and renal cell carcinoma (RCC) evaluated the safety and maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of recombinant human interleukin-21 (rIL-21).
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
van der Meer et al., Nijmegen, Netherlands. In Nat Med, 2006
Recombinant IL-18 (rIL-18) administered intracerebrally inhibited food intake.
Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein.
Gullans et al., Berlin, Germany. In Immunity, 1998
Diminished proliferation but not IFN-gamma secretion is reversible by exogenous rIL-2.
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