Hematopoietic neoplasms in Prkar2a-deficient mice.
Bethesda, United States. In J Exp Clin Cancer Res, 2014
Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RIIα and RIIβ, respectively) are also viable but have not been studied for their susceptibility to any tumors.
Psychosis pathways converge via D2high dopamine receptors.
Toronto, Canada. In Synapse, 2006
Mice born with gene knockouts of some possible schizophrenia susceptibility genes are dopamine supersensitive, and their striata reveal markedly elevated D2High states; suchgenes include dopamine-beta-hydroxylase, dopamine D4 receptors, G protein receptor kinase 6, tyrosine hydroxylase, catechol-O-methyltransferase, the trace amine-1 receptor, regulator of G protein signaling RGS9, and the RIIbeta form of cAMP-dependent protein kinase (PKA).
Tumor reversion: protein kinase A isozyme switching.
Bethesda, United States. In Ann N Y Acad Sci, 2005
DNA microarrays demonstrate that antisense suppression of the RIalpha, which upregulates RIIbeta, downregulates a wide range of genes involved in cell proliferation and transformation while upregulating cell differentiation and reverse transformation genes in PC3M prostate tumors that undergo regression.