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Rap1 interacting factor 1 homolog

RIF-1
This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, CIs, V1a
Papers on RIF-1
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.
New
Pei et al., Chongqing, China. In Nat Commun, Dec 2015
Subsequently, UHRF1 mediates K63-linked polyubiquitination of RIF1, and results in its dissociation from 53BP1 and DSBs thereby facilitating HR initiation.
Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features.
New
Rebelo et al., Aveiro, Portugal. In Membranes (basel), Dec 2015
Several functionally relevant proteins, such as TRF2, TERF2IP, RIF1, ATM, MAD2L1 and MAD2L1BP were identified and these support the putative functions proposed for LAP1.
Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin.
New
Rudner et al., Ottawa, Canada. In Plos Genet, Nov 2015
Deleting RIF1 and RIF2, which suppresses the subtelomeric silencing defects in these mutants, rescues the advanced de novo establishment in yku70Δ and ubp10Δ cells, but not in dot1Δ cells, suggesting that YKU70 and UBP10 regulate Sir4 availability by modulating subtelomeric silencing, while DOT1 functions directly to regulate establishment.
Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.
New
Rosselli et al., Villejuif, France. In Nucleic Acids Res, Nov 2015
Thus, FA pathway loss-of-function results in accumulation of 53BP1, RIF1 and RAP80 at damaged chromatin, which impair DNA resection at stalled replication fork-associated DNA breaks and impede HR.
Mutations in circularly permuted GTPase family genes AtNOA1/RIF1/SVR10 and BPG2 suppress var2-mediated leaf variegation in Arabidopsis thaliana.
New
Yu et al., China. In Photosynth Res, Nov 2015
Genetic mapping and molecular complementation indicated that SVR10 encodes a circularly permuted GTPase that has been reported as Arabidopsis thaliana NITRIC OXIDE ASSOCIATED 1 (AtNOA1) and RESISTANT TO INHIBITION BY FOSMIDOMYCIN 1 (RIF1).
Integrated miRNA and mRNA expression profiling of tension force-induced bone formation in periodontal ligament cells.
New
Han et al., Wuhan, China. In In Vitro Cell Dev Biol Anim, Sep 2015
WDR33, HSPH1, ERBB3, RIF1, IKBKB, CREB1, FGF2, and PAG1 were identified as hubs of the PPI network, suggesting the biological significance in this process.
Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
New
Ohta et al., Kawasaki, Japan. In Cancer Sci, Aug 2015
Reflecting their effects on histone modifications, the HDAC inhibitors inhibit ionizing radiation-induced foci (IRIF) formation of BRCA1 and BARD1 as well as 53BP1 and RIF1, whereas UNC0638 suppresses IRIF formation of BRCA1 and BARD1 but not 53BP1 and RIF1.
MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.
New
Impact
Jacobs et al., Amsterdam, Netherlands. In Nature, Jun 2015
End resection blocks NHEJ while committing to homology-directed repair, and is under the control of 53BP1, RIF1 and PTIP.
Putative regulatory factors associated with intramuscular fat content.
Coutinho et al., Piracicaba, Brazil. In Plos One, 2014
RIF and PIF analyses identified several candidate genes: GLI2 and IGF2 (RIF1), MPC1 and UBL5 (RIF2) and a host of small RNAs, including miR-1281 (PIF).
A candidate factor that interacts with RF2, a restorer of fertility of Lead rice-type cytoplasmic male sterility in rice.
Toriyama et al., Sendai, Japan. In Rice (n Y), 2014
We identified four genes and named RF2-interacting candidate factors (RIF1 to RIF4).
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Impact
Nussenzweig et al., Bethesda, United States. In Cell, 2013
The pro-NHEJ and antirecombinase functions of 53BP1 are mediated in part by RIF1, the only known factor that requires 53BP1 phosphorylation for its recruitment to double-strand breaks (DSBs).
A novel checkpoint and RPA inhibitory pathway regulated by Rif1.
GeneRIF
Maringele et al., Newcastle upon Tyne, United Kingdom. In Plos Genet, 2011
Rif1 has important physiological roles in preventing a cell cycle arrest to incipient or small single stranded DNA lesions occurring on chromosomes, particularly on chromosome ends.
An anti-checkpoint activity for rif1.
GeneRIF
Kupiec et al., Tel Aviv-Yafo, Israel. In Plos Genet, 2011
Saccharomyces cerevisiae Rif1 is an important telomeric factor with an anti-checkpoint role.
Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1.
GeneRIF
Fox et al., Madison, United States. In Proc Natl Acad Sci U S A, 2011
data supported a model in which Pfa4-dependent palmitoylation of Rif1 anchored it to the inner nuclear membrane, influencing its role in heterochromatin dynamics
Insulin-like 6 is induced by muscle injury and functions as a regenerative factor.
GeneRIF
Walsh et al., Boston, United States. In J Biol Chem, 2010
Data indicate that Insl6 is an injury-regulated myokine that functions as a myogenic regenerative factor.
Mammalian Rif1 contributes to replication stress survival and homology-directed repair.
GeneRIF
de Lange et al., New York City, United States. In J Cell Biol, 2009
Rif1 has a role in the repair of stalled replication forks by facilitating homology-directed repair.
Antitumour prodrug development using cytochrome P450 (CYP) mediated activation.
Review
Orr et al., London, United Kingdom. In Anticancer Drug Des, 1999
This study shows that freshly isolated murine T50/80 mammary carcinoma and RIF-1 fibrosarcoma 4-electron reduces AQ4N to its cytotoxic metabolite, AQ4 (T50/80 Km = 26.7 microM, Vmax = 0.43 microM/mg protein/min; RIF-1 Km = 33.5 microM, Vmax = 0.42 microM/mg protein/min) via AQM, a mono-N-oxide intermediate (T50/80 Km = 37.5 microM; Vmax = 1.4 microM/mg protein/min; RIF-1 Km = 37.5 microM; Vmax = 1.2 microM/mg protein/ min).
Novel N-oxides as bioreductive drugs.
Review
Naylor, United Kingdom. In Oncol Res, 1993
These compounds had differential cytotoxicities in vitro of up to 20 for 8-amino derivatives such as RB90740 and 65 for 8-aminoalkoxy derivatives such as 1,2-dihydro-8-(1-(demethylamino)ethoxy)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide, but were disappointing in vivo with a maximum growth delay of 10 days compared with 30 days for SR4233 in the RIF-1 tumor model.
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation.
Review
Bremner, Didcot, United Kingdom. In Cancer Metastasis Rev, 1993
If either RSU1069 or RB6145 are administered during PDT, very large increases in the growth delay induced by PDT alone are seen for the RIF-1 murine tumour.
Experimental chemotherapy studies: intercomparison of assays.
Review
Twentyman, In Br J Cancer Suppl, 1980
New data are also presented for the RIF-1 tumour and for multicellular tumour spheroids of the EMT6/Ca/VJAC line.
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