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FXYD domain containing ion transport regulator 5

RIC, Dysadherin, FXYD5
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, Ric-8, HAD, E-cadherin, Cholinesterase
Papers on RIC
Mirebeau-Prunier et al., Angers, France. In Shock, Feb 2016
The mechanisms by which remote ischemic conditioning (RIC) is protective are to date unknown, yet a well-accepted theory holds that the mitochondria play a central role.
The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial.
Antin et al., Boston, United States. In Br J Haematol, Feb 2016
A retrospective study suggested that patients with lymphoma undergoing reduced intensity conditioning (RIC) HSCT who received sirolimus as part of their GVHD prophylaxis regimen had a lower rate of relapse.
The CREB Transcription Factor Controls Transcriptional Activity of the Human RIC8B Gene.
Gutiérrez et al., Concepción, Chile. In J Cell Biochem, Feb 2016
Differential expression profiles of mRNA coding for vertebrate Ric-8B during embryo and adult stages have been observed.
Confounders of Cardioprotection by Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting.
Heusch et al., Essen, Germany. In Cardiology, Dec 2015
OBJECTIVES: Remote ischemic conditioning (RIC) by repetitive blood pressure cuff inflation/deflation around a limb provides cardioprotection in patients undergoing coronary artery bypass grafting (CABG).
Revisiting Apoplastic Auxin Signaling Mediated by AUXIN BINDING PROTEIN 1.
Kim et al., Chinju, South Korea. In Mol Cells, Dec 2015
ROPs interact with their effectors, such as the ROP interactive CRIB motif-containing protein (RIC), to regulate the endocytosis/exocytosis of the auxin efflux carrier PIN-FORMED (PIN) proteins to mediate polar auxin transport across the PM.
Cardioprotection by remote ischemic conditioning: Mechanisms and clinical evidences.
Passino et al., Pisa, Italy. In World J Cardiol, Nov 2015
In remote ischemic conditioning (RIC), several cycles of ischemia and reperfusion render distant organ and tissues more resistant to the ischemia-reperfusion injury.
Bone marrow or peripheral blood for reduced-intensity conditioning unrelated donor transplantation.
Champlin et al., Milwaukee, United States. In J Clin Oncol, Mar 2015
PURPOSE: There have been no randomized trials that have compared peripheral blood (PB) with bone marrow (BM) grafts in the setting of reduced-intensity conditioning (RIC) transplantations for hematologic malignancy.
Remote ischemic conditioning.
Yellon et al., Essen, Germany. In J Am Coll Cardiol, Feb 2015
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury.
The G protein α chaperone Ric-8 as a potential therapeutic target.
Tall et al., Rochester, United States. In Mol Pharmacol, 2015
Resistance to inhibitors of cholinesterase (Ric-8)A and Ric-8B are essential genes that encode positive regulators of heterotrimeric G protein α subunits.
FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas.
Tozeren et al., Philadelphia, United States. In Cancer Inform, 2014
Based on our analysis, we identified FXYD5, a glycoprotein known to reduce cell adhesion, as a potential driver of metastasis and a significant predictor of mortality in OC.
Allogeneic hematopoietic stem cell transplantation in adult acute lymphoblastic leukemia: potential benefit of medium-dose etoposide conditioning.
Shigematsu et al., Sapporo, Japan. In Exp Hematol Oncol, 2014
By contrast, reduced-intensity conditioning (RIC) regimens have also been applied to adult ALL patients and favorable outcomes have been obtained; however, relapse and TRM rates remain high.
Bortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation.
Alyea et al., Boston, United States. In J Clin Oncol, 2012
In reduced-intensity conditioning (RIC), neither ex vivo nor in vivo T-cell depletion (eg, antithymocyte globulin) convincingly improved outcomes.
Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension.
Geng et al., Wenzhou, China. In Int J Mol Med, 2012
FXYD5 may have profound impact on the regulation of blood pressure.
FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells.
Garty et al., Israel. In Am J Physiol Renal Physiol, 2011
Expressing FXYD5 in mouse kidney collecting duct cell line M1 led to a large decrease in amiloride-insensitive transepithelial electrical resistance as well as increased permeability to 4-kDa dextran.
Expression of dysadherin in the human male reproductive tract and in spermatozoa.
Vazquez-Levin et al., Buenos Aires, Argentina. In Fertil Steril, 2011
This is the first report on expression of dysadherin in the male gonad and in spermatozoa.
Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6.
Bellen et al., Houston, United States. In Neuron, 2011
Rich activates Rab6 to regulate N-Cadherin trafficking and affects synaptic specificity.
Immunohistochemical study of correlation between histologic subtype and expression of epithelial-mesenchymal transition-related proteins in synovial sarcomas.
Llombart-Bosch et al., Valencia, Spain. In Arch Pathol Lab Med, 2011
Overexpression of Snail, Slug, and dysadherin and activation of Wnt and PI3K/Akt signaling was associated with inactivated E-cadherin in the spindle cells of monophasic fibrous synovial sarcomas.
Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning.
Antin et al., Boston, United States. In J Clin Oncol, 2009
The benefit was restricted to patients undergoing reduced-intensity conditioning (RIC) HSCT (3-year OS, 66% for sirolimus group v 38% for no-sirolimus group; P = .007;
Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells.
Adhya et al., Calcutta, India. In Science, 2006
We found that the Leishmania RNA import complex (RIC) could enter human cells by a caveolin-1-dependent pathway, where it induced import of endogenous cytosolic tRNAs, including tRNA(Lys), and restored mitochondrial function in a cybrid harboring a mutant mt tRNA(Lys) (MT-TK) gene.
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins.
Yu et al., Singapore, Singapore. In Nat Cell Biol, 2005
Another key component of this non-canonical G-protein activation mechanism is a non-receptor guanine nucleotide-exchange factor (GEF) for Galpha, RIC-8, which has recently been characterized in C. elegans and in mammals.
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