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Ribosomal protein S6

ribosomal protein S6, RPS6
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: mTOR, p70S6K, Akt, V1a, Insulin
Papers using ribosomal protein S6 antibodies
G protein coupled receptors as allosteric proteins and the role of allosteric modulators
Obukhov Alexander G., In PLoS ONE, 2009
... Antibodies against phospho-ERK1/2 and ribosomal protein S6 were purchased from Santa Cruz Biotechnology, Inc ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method.
Perrimon Norbert, In PLoS Genetics, 2000
... UAS-RpS6 transgenic lines for overexpression were ...
Papers on ribosomal protein S6
Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.
Hall et al., Basel, Switzerland. In Proc Natl Acad Sci U S A, Feb 2016
Sorafenib was confirmed to inhibit MAPK signaling in the tumor, as measured by reduced ribosomal protein S6 kinase phosphorylation.
Effects of testosterone treatment on markers of skeletal muscle ribosome biogenesis.
Roberts et al., Auburn, United States. In Andrologia, Feb 2016
Finally, lower phospho-(Ser235/236)-to-total rps6 protein and lower rpl5 protein levels existed in ORX+TEST rats versus other treatments, suggesting that chronic TEST treatment may lower translational capacity.
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism.
Rasmussen et al., Galveston, United States. In J Nutr, Feb 2016
Supplementation of protein/AAs with RE exhibited clear protein dose-dependent effects on translational regulation (protein synthesis) through mammalian target of rapamycin complex 1 (mTORC1) signaling, which was most apparent through increases in p70 ribosomal protein S6 kinase 1 (S6K1) phosphorylation, compared with postexercise recovery in the fasted or carbohydrate-fed state.
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
Sun et al., Harbin, China. In J Vasc Surg, Feb 2016
GYY4137 attenuated the increase of Ang2 release and expression and increased the phosphorylation of Akt and the activation of its downstream factors, glycogen synthase kinase 3β and ribosomal protein S6 kinase; PAG showed opposite effects.
Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway.
Pospelov et al., Saint Petersburg, Russia. In Cell Death Dis, Dec 2015
When LIF is withdrawn from culture medium, the mTOR activity rapidly increases as detected by phosphorylation of its targets - ribosomal protein S6 and translation factor 4EBP1.
β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling.
Zhang et al., Yangzhou, China. In Oncol Lett, Dec 2015
In addition, β-HIVS markedly reduced the expression levels of PI3K, AKT, mTOR and 70-kDa ribosomal protein S6 kinase in HeLa cells.
A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus.
Clifton et al., Australia. In Metabolism, Jul 2015
BCAAs may induce insulin resistance via the mammalian target of rapamycin complex 1 (mTORC1) and ribosomal protein S6 kinase β 1 (S6k1)-associated pathways.
EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.
Visvader et al., Australia. In Nat Cell Biol, Apr 2015
Interestingly, EGF was identified as one of the most highly upregulated genes on lactogenesis and inhibition of EGF or mTOR signalling markedly impaired lactation, with concomitant decreases in Mcl-1 and phosphorylated ribosomal protein S6.
[Research progress of p70 ribosomal protein S6 kinase inhibitors].
Li et al., In Yao Xue Xue Bao, Mar 2015
p70 ribosomal protein S6 kinase (p70S6K), an important member of AGC family, is a kind of multifunctional Ser/Thr kinases, which plays an important role in mTOR signaling cascade.
Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function.
Puighermanal et al., Montpellier, France. In Front Mol Neurosci, 2014
Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four decades ago, much effort has been made to uncover the molecular mechanisms underlying the regulation of this post-translational modification.
Nutritional and regulatory roles of leucine in muscle growth and fat reduction.
Yin et al., Key West, United States. In Front Biosci, 2014
Specifically, leucine activates the mammalian target of rapamycin (mTOR) signaling pathway, including the 70 kDa ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E-binding protein 1 (4EBP1) to stimulate protein synthesis in skeletal muscle and adipose tissue and to promote mitochondrial biogenesis, resulting in enhanced cellular respiration and energy partitioning.
Systems biology. Conditional density-based analysis of T cell signaling in single-cell data.
Nolan et al., New York City, United States. In Science, 2014
We validated our characterization on mice lacking the extracellular-regulated mitogen-activated protein kinase (MAPK) ERK2, which showed stronger influence of pERK on pS6 (phosphorylated-ribosomal protein S6), in naïve cells as compared with antigen-exposed cells, as predicted.
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.
Janes et al., Charlottesville, United States. In Nat Cell Biol, 2014
The circuit depends on ECM engagement, as detachment causes a rewiring that is triggered by RPS6 dephosphorylation and maintained by juxtacrine tenascin C, which is critical for intraductal colonization of basal-like breast cancer cells in vivo.
Prognostic significance of MTOR pathway component expression in neuroendocrine tumors.
Kulke et al., Boston, United States. In J Clin Oncol, 2013
PATIENTS AND METHODS: We evaluated immunohistochemical expression of MTOR and phospho (p) -MTOR; its downstream targets RPS6KB1, RPS6, and EIF4EBP1; and its upstream regulators, in a cohort of 195 archival neuroendocrine tumors.
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Manning et al., Boston, United States. In Science, 2013
mTORC1 signaling posttranslationally regulated this metabolic pathway via its downstream target ribosomal protein S6 kinase 1 (S6K1), which directly phosphorylates S1859 on CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, dihydroorotase), the enzyme that catalyzes the first three steps of de novo pyrimidine synthesis.
pS6 Expression in normal renal parenchyma, primary renal cell carcinomas and their metastases.
Kolbitsch et al., Salzburg, Austria. In Pathol Oncol Res, 2012
High Ribosomal Protein S6 is associated with renal cell carcinoma metastases.
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Zhu et al., Baltimore, United States. In Lab Invest, 2011
Nearly 20-fold more neurons contain pS6-positive granules in Alzheimer's disease hippocampus compared to age-matched controls.
Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1.
Ubukata et al., Sapporo, Japan. In Biosci Biotechnol Biochem, 2011
a novel mechanism for modulating the RPS6 function by PP1 and ATM which regulates cell growth and survival in response to DNA-damage stim
Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus.
Dittmer et al., Chapel Hill, United States. In J Virol, 2011
Here, the authors show that ribosomal protein S6 (RPS6) interacts with LANA.
The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.
Camenisch et al., Zürich, Switzerland. In Plos One, 2010
Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6.
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