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Ribosomal protein S3A

ribosomal protein S3a, Fte-1, RPS3a
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. Transcript variants utilizing alternative transcription start sites have been described. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Fos, CAN, p56, STEP
Papers on ribosomal protein S3a
Dengue virus NS1 protein interacts with the ribosomal protein RPL18: this interaction is required for viral translation and replication in Huh-7 cells.
Del Angel et al., Mexico. In Virology, Oct 2015
The subcellular location and expression levels during infection of the ribosomal proteins RPS3a, RPL7, RPL18, RPL18a plus GAPDH were determined.
Immune- and ribosome-related genes were associated with systemic vasculitis.
Tang et al., Shanghai, China. In Scand J Immunol, Feb 2015
Furthermore, human leucocyte antigen (HLA)-DRB1, HLA-DPA1, HLA-DPB1, HLA-DOA and HLA-DRA in the downregulated modules were significantly linked to immune-related pathways (intestinal immune network for IgA production and systemic lupus erythematosus pathways), while ribosomal protein L 31 (RPL31), RPS3A and RPL9 in the upregulated module were enriched in ribosome pathway.
GmSGT1 is differently required for soybean Rps genes-mediated and basal resistance to Phytophthora sojae.
Dou et al., Nanjing, China. In Plant Cell Rep, 2014
In contrast, the resistance mediated by Rps2 or Rps3a was not affected.
Re-analysis of cryoEM data on HCV IRES bound to 40S subunit of human ribosome integrated with recent structural information suggests new contact regions between ribosomal proteins and HCV RNA.
Srinivasan et al., Bengaluru, India. In Rna Biol, 2013
We found that domain IIIe makes contact with the ribosomal protein S3a (S1e).
Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system.
Thevelein et al., Leuven, Belgium. In Biochem J, 2013
The mouse ribosomal and chaperone protein RPS3A was identified as a suppressor of αSyn [WT (wild-type) and A53T] toxicity in yeast.
Transgenerational gene silencing causes gain of virulence in a plant pathogen.
Gijzen et al., London, Canada. In Nat Commun, 2012
P. sojae strains with detectable Avr3a gene transcripts are avirulent on plants carrying the R-gene Rps3a, whereas strains lacking Avr3a mRNA escape detection by Rps3a and are virulent.
Differential display of abundantly expressed genes of Trichoderma harzianum during colonization of tomato-germinating seeds and roots.
Mahdikhani-Moghaddam et al., Mashhad, Iran. In Curr Microbiol, 2012
Most of transcripts (29 EST) corresponds to known and hypothetical proteins such as secretion-related small GTPase, 40S ribosomal protein S3a, 3-hydroxybutyryl-CoA dehydrogenase, DNA repair protein rad50, lipid phosphate phosphatase-related protein type 3, nuclear essential protein, phospholipase A2, fatty acid desaturase, nuclear pore complex subunit Nup133, ubiquitin-activating enzyme, and 60S ribosomal protein L40.
Cu(II)-induced molecular and physiological responses in the brown-rot basidiomycete Polyporales sp. KUC9061.
Kim et al., Seoul, South Korea. In J Appl Microbiol, 2012
Increased expression of the genes encoding for the GIS2 DNA-binding protein and the 40S ribosomal protein S3A appears to be involved in this process.
RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-κB signaling via its novel chaperoning function.
Seong et al., Seoul, South Korea. In Plos One, 2010
Results suggest that RPS3a, via extra-ribosomal chaperoning function for HBx, contributes to virally induced oncogenesis by enhancing HBx-induced NF-kappaB signaling pathway.
Sequence variants of the Phytophthora sojae RXLR effector Avr3a/5 are differentially recognized by Rps3a and Rps5 in soybean.
Gijzen et al., London, Canada. In Plos One, 2010
Transformation of P. sojae and transient expression in soybean were performed to test how Avr3a/5 alleles interact with soybean Rps3a and Rps5.
RNA interference directed against ribosomal protein S3a suggests a link between this gene and arrested ovarian development during adult diapause in Culex pipiens.
Denlinger et al., Columbus, United States. In Insect Mol Biol, 2010
In this study we propose that ribosomal protein S3a (rpS3a), a small ribosomal subunit, contributes to this shutdown.
HUPO BPP pilot study: a proteomics analysis of the mouse brain of different developmental stages.
Zhang et al., Beijing, China. In Proteomics, 2007
The proteins alpha-enolase, stathmin, actin, C14orf166 homolog, 28,000 kDa heat- and acid-stable phosphoprotein, 3-mercaptopyruvate sulfurtransferase and 40 S ribosomal protein S3a were successfully identified.
Comparative sequence analysis of the complete set of 40S ribosomal proteins in the Senegalese sole (Solea senegalensis Kaup) and Atlantic halibut (Hippoglossus hippoglossus L.) (Teleostei: Pleuronectiformes): phylogeny and tissue- and development-specific expression.
Douglas et al., Cadiz, Spain. In Bmc Evol Biol, 2006
Steady-state transcript levels for eight RPs (RPS2, RPS3a, RPS15, RPS27-1, RPS27-2, RPS27a, RPS28, and RPS29) in sole were quantitated during larval development and in tissues, using a real-time PCR approach.
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Goate et al., Alameda, United States. In Am J Hum Genet, 2006
Variants in the RPS3A homologue are associated with late-onset Alzheimer disease and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder.
[The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer].
Sverdlov et al., In Bioorg Khim, 2005
RPS3A expression in patients with squamous cell lung cancer increased by 70% which makes it a highly informative marker of squamous cell lung cancer
Identification of ribosomal protein S3a as a candidate for a novel PI 3-kinase target in the nucleus.
Fukui et al., Tokyo, Japan. In Cytotechnology, 2002
A 33 kD protein was detected in this method, which was identified as ribosomal protein S3a by the mass spectrometric analysis.
Characterization of human ribosomal S3a gene expression during adenosine 3':5' cyclic monophosphate induced neuroendocrine differentiation of LNCaP cells. Regulation of S3a gene expression in LNCaP.
Rutherford et al., Blacksburg, United States. In Mol Biol Rep, 2002
regulation of ribosomal S3a gene expression during cyclic amp induced neuroendocrine differentiation of LNCaP cells
Involvement of ribosomal proteins in regulating cell growth and apoptosis: translational modulation or recruitment for extraribosomal activity?
Naora, Canberra, Australia. In Immunol Cell Biol, 1999
Recently, we have shown that ribosomal protein S3a (RPS3a) plays important roles in cell transformation and death, whereby constitutively or transiently enhanced RPS3a expression can be regarded as 'priming' a cell for apoptosis and suppression of such enhanced expression as 'execution'.
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