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Ribosomal protein L11

ribosomal protein L11, RPL11
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: p53, mdm2, CAN, ACID, HAD
Papers on ribosomal protein L11
The ribosome biogenesis pathway as an early target of benzyl butyl phthalate (BBP) toxicity in Chironomus riparius larvae.
Morcillo et al., Madrid, Spain. In Chemosphere, Feb 2016
In the present study, the interaction of BBP with the ribosome biogenesis pathway and the general transcriptional profile of Chironomus riparius aquatic larvae were investigated by means of changes in the rDNA activity (through the study of the internal transcribed spacer 2, ITS2) and variations in the expression profile of ribosomal protein genes (rpL4, rpL11, and rpL13) after acute 24-h and 48-h exposures to a wide range of BBP doses.
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
Pearson et al., Melbourne, Australia. In Cancer Discov, Jan 2016
CX-5461 induced nucleolar stress and p53 pathway activation, whereas everolimus induced expression of the proapoptotic protein BMF that was independent of p53 and reduced expression of RPL11 and RPL5.
Down-regulation of 5S rRNA by miR-150 and miR-383 enhances c-Myc-rpL11 interaction and inhibits proliferation of esophageal squamous carcinoma cells.
Yang et al., Beijing, China. In Febs Lett, Jan 2016
Moreover, 5S rRNA silencing by miR-150 and miR-383 might intensify rpL11-c-Myc interaction, which attenuated role of c-Myc as an oncogenic transcriptional factor and dysregulation of multiple c-Myc target genes.
Normalization of Reverse Phase Protein Microarray Data: Choosing the Best Normalization Analyte.
Chiechi, Indianapolis, United States. In Methods Mol Biol, Dec 2015
Using geNorm and NormFinder algorithms, we screened seven normalization analytes (ssDNA, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), α/β-tubulin, mitochondrial ribosomal protein L11 (MRPL11), ribosomal protein L13a (RPL13a), β-actin, and total protein) across different sample sets, including cell lines, blood contaminated tissues, and tissues subjected to laser capture microdissection (LCM), to identify the analyte with the lowest variability.
Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis.
Serrano et al., Madrid, Spain. In Cell Rep, Nov 2015
Diamond-Blackfan anemia (DBA) is characterized by anemia and cancer susceptibility and is caused by mutations in ribosomal genes, including RPL11.
Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability.
Zhang et al., Chapel Hill, United States. In Oncotarget, 2014
Of the RPs that bind to MDM2, RPL5 and RPL11 are the most studied and RPL11 appears to have the most significant role in p53 regulation.
Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner.
Xirodimas et al., Dundee, United Kingdom. In Oncogene, 2012
The studies provide insights on how nucleolar stress through L11 and NEDD8 can activate the transcriptional activity of p53.
Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.
Lu et al., Indianapolis, United States. In J Biol Chem, 2012
ARF activates p53, at least partly by induction of ribosomal stress, which results in L11 suppression of MDM2
A new PICTure of nucleolar stress.
Mori et al., Fukuoka, Japan. In Cancer Sci, 2012
PICT1 sequesters the ribosomal protein RPL11 in the nucleolus, preventing it from binding to MDM2.
Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.
DBA Group of Société d'Hématologie et d'Immunologie Pédiatrique-SHIP et al., Villejuif, France. In Cell Death Dis, 2011
RPL11 mutations led to a dramatic decrease in progenitor cell proliferation and a delayed erythroid differentiation with a marked increase in apoptosis and G0/1 cell cycle arrest with activation of p53.
Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation.
Lu et al., Indianapolis, United States. In J Biol Chem, 2011
Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation
Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress.
Dai et al., Portland, United States. In Mol Cell Biol, 2011
Results identify a novel regulatory paradigm wherein L11 plays a critical role in controlling c-myc mRNA turnover via recruiting miR-24/miRISC in response to ribosomal stress.
DePICTing p53 activation: a new nucleolar link to cancer.
Oren et al., Israel. In Cancer Cell, 2011
PICT1 sequesters ribosomal protein RPL11 in the nucleolus, attenuating p53 induction.
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Suzuki et al., Akita, Japan. In Nat Med, 2011
Pict1 binds Rpl11, and Rpl11 is released from nucleoli in the absence of Pict1.
Untangling the phenotypic heterogeneity of Diamond Blackfan anemia.
Dahl et al., Baltimore, United States. In Semin Hematol, 2011
Recent advances in identifying the genetic abnormalities underlying DBA have demonstrated involvement of genes encoding both large (RPL) and small (RPS) ribosomal subunit proteins, including mutations of RPL5, RPL11, RPL35A, RPS7, RPS10, RPS17, RPS19, RPS24, and RPS26 in 50% to 60% of affected patients.
The RP-Mdm2-p53 pathway and tumorigenesis.
Zhang et al., Chapel Hill, United States. In Oncotarget, 2011
We generated mice carrying a single cysteine-to-phenylalanine substitution in the central zinc finger of Mdm2 (Mdm2C305F) that disrupts Mdm2's binding to RPL11 and RPL5.
Molecular pathogenesis in Diamond-Blackfan anemia.
Terui et al., Hirosaki, Japan. In Int J Hematol, 2010
Mutations in RPL5 and RPL11 are at a high risk for developing malformation.
An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.
Zhang et al., Chapel Hill, United States. In Cancer Cell, 2010
To study the physiological significance of the RP-Mdm2 interaction, we generated mice carrying a cancer-associated cysteine-to-phenylalanine substitution in the zinc finger of Mdm2 that disrupted its binding to RPL5 and RPL11.
Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.
Thomas et al., In Nat Cell Biol, 2009
The cell selectively upregulates the translation of mRNAs with a polypyrimidine tract at their 5'-transcriptional start site (5'-TOP mRNAs), including that encoding rpL11, on impairment of 40S ribosome biogenesis.
Regulation of HDM2 activity by the ribosomal protein L11.
Vousden et al., Frederick, United States. In Cancer Cell, 2003
In this report, we show that the ribosomal protein L11 can interact with HDM2 and inhibit HDM2 function, thus leading to the stabilization and activation of p53.
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