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Ribophorin II

ribophorin II, RPN2, Swp1p, SWP1, SEN3
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: estrogen sulfotransferase, ACID, CAN, STEP, CD45
Papers on ribophorin II
Physiological and genomic characterisation of Saccharomyces cerevisiae hybrids with improved fermentation performance and mannoprotein release capacity.
New
Querol et al., Paterna, Spain. In Int J Food Microbiol, Aug 2015
The hybrid shared not only a similar copy number of genes SPR1, SWP1, MNN10 and YPS7 related to cell wall integrity with parental Sc1, but also a similar copy number of some glycolytic genes with parental Sc2, such as GPM1 and HXK1, as well as the genes involved in hexose transport, such as HXT9, HXT11 and HXT12.
The expression and clinical significance of ribophorin II (RPN2) in human breast cancer.
New
Ochiya et al., Tokyo, Japan. In Pathol Int, Jun 2015
Ribophorin II (RPN2), part of the N-oligosaccharyltransferase complex, is highly expressed in breast cancer stem cells and is associated with tumor metastasis through interaction with mutant p53.
Role of ribophorin II in the response to anticancer drugs in gastric cancer cell lines.
New
Chuang et al., T'ai-chung-shih, Taiwan. In Oncol Lett, Apr 2015
Ribophorin II (RPN2) has been demonstrated to be a prognostic marker of human cancer, including breast and pancreatic cancers.
Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.
New
Ochiya et al., Tokyo, Japan. In Oncotarget, Mar 2015
Previously, we demonstrated that ribophorin II (RPN2), which is part of the N-oligosaccharyl transferase complex, regulates docetaxel sensitivity and tumor lethal phenotypes in breast cancer.
Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer.
Bi et al., Wuhan, China. In Cell Biosci, 2014
This led to the identification of eight candidate genes including RPN2, HMGB1, AARS, IGFBP3, STAT1, HYOU1, NQO1 and PEA15 that were associated with the progressive phenotype.
First characterization in China of Encephalitozoon cuniculi in the blue fox (Alopex lagopus).
Zhang et al., Harbin, China. In J Eukaryot Microbiol, 2014
Furthermore, phylogenetic analysis of the PTP1 gene verifies classification of this new strain (termed LN-1) with other genotype III E. cuniculi strains, though the PTP3 and SWP1 sequences diverge from the reference strain.
Evaluation of spore wall protein 1 as an alternative antigen for the diagnosis of Encephalitozoon cuniculi infection of farmed foxes using an enzyme-linked immunosorbent assay.
Jia et al., Harbin, China. In Vet Parasitol, 2014
The sequence encoding SWP1 was cloned from the genome of Encephalitozoon cuniculi.
Sequences type analysis of Candida albicans isolates from Iranian human immunodeficiency virus infected patients with oral candidiasis.
Hajiabdolbaghi et al., Tabrīz, Iran. In Acta Med Iran, 2013
After diagnostic test and DNA extraction C. albicans isolates were typed using the original MLST scheme explained previously include of six loci: ACC1, VPS13, GLN4, ADP1, RPN2, and SYA1.
VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.
Alexandru et al., Dundee, United Kingdom. In Bmc Biol, 2013
Our efforts to determine the identity of the ubiquitinated targets common to VAPB and FAF1 led to the identification of RPN2, a subunit of an oligosaccharyl-transferase located at the endoplasmic reticulum, which may be regulated by ubiquitin-mediated degradation.
RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.
Ochiya et al., Tokyo, Japan. In Mol Cancer, 2013
Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is responsible for drug resistance in breast cancer cells.
RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis.
Ochiya et al., Tokyo, Japan. In Mol Ther Nucleic Acids, 2013
We previously demonstrated that silencing of ribophorin II (RPN2), which is part of the N-oligosaccharyl transferase complex, efficiently induced apoptosis and reduced resistance to docetaxel in human breast cancer cells.
Comparative analysis of nutritional quality of five different cultivars of sweet potatoes (Ipomea batatas (L) Lam) in Sri Lanka.
Bamunuarachchi et al., Sri Jayewardenepura Kotte, Sri Lanka. In Food Sci Nutr, 2013
Higher percentage of resistant starch from total starch was found in Wariyapola red (swp1) cultivar resulting in lower digestion level while higher levels of digestion was evident in cultivars with lower levels of resistant starch with high level of total starch.
Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.
GeneRIF
Glickman et al., Haifa, Israel. In J Biol Chem, 2012
Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.
Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.
GeneRIF
Walters et al., Minneapolis, United States. In Mol Cell, 2010
Rpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding.
Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.
GeneRIF
Shaul et al., Israel. In J Biol Chem, 2009
Data show that the decay of metabolically labeled p53 follows biphasic kinetics, while 20 S proteasome executes the first phase by default, and the second phase requires the 26 S proteasome.
S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function.
GeneRIF
Abraham et al., Birmingham, United States. In J Biol Chem, 2009
S-glutathionylation of Rpn2 is a contributory mechanism for H2O2-induced inhibition of 26 S proteasomal function
Electron microscopic evidence in support of alpha-solenoid models of proteasomal subunits Rpn1 and Rpn2.
GeneRIF
Steven et al., Bethesda, United States. In J Mol Biol, 2009
Comparison of the full-length Rpn1 and Rpn2 with the truncated proteins showed molecules similar in size and shape, indicating that their terminal regions are flexible and thus smeared to invisibility in the averaged images.
RPN2 gene confers docetaxel resistance in breast cancer.
Impact
GeneRIF
Ochiya et al., Tokyo, Japan. In Nat Med, 2008
RPN2 gene confers docetaxel resistance in breast cancer.
Studies on oligosaccharyl transferase in yeast.
Review
Lennarz, Stony Brook, United States. In Acta Biochim Pol, 2006
In yeast, five of these proteins are encoded by essential genes, Swp1p, Wbp1p, Ost2p, Ost1p and Stt3p.
An evolving view of the eukaryotic oligosaccharyltransferase.
Review
Gilmore et al., Worcester, United States. In Glycobiology, 2006
The yeast and vertebrate OST are surprisingly complex hetero-oligomeric proteins consisting of seven or eight subunits (Ost1p, Ost2p, Ost3p/Ost6p, Ost4p, Ost5p, Stt3p, Wbp1p, and Swp1p in yeast; ribophorin I, DAD1, N33/IAP, OST4, STT3A/STT3B, Ost48, and ribophorin II in mammals).
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