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Drosha, ribonuclease type III

Ribonuclease III, Drosha
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008] (from NCBI)
Papers on Ribonuclease III
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.
GeneRIF
Cáceres et al., Edinburgh, United Kingdom. In Nat Struct Mol Biol, 2012
DGCR8-mediated cleavage of snoRNAs was independent of Drosha, suggesting the involvement of DGCR8 in cellular complexes with other endonucleases. Binding of DGCR8 to cassette exons is a new mechanism for regulation of alternatively spliced isoforms.
The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis.
GeneRIF
Yan et al., Reno, United States. In J Biol Chem, 2012
DROSHA is essential mainly for the canonical miRNA production, and DROSHA-mediated miRNA production is essential for normal spermatogenesis and male fertility.
Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.
GeneRIF
Taylor et al., Freiburg, Germany. In Nat Neurosci, 2012
Drosha is required for maintenance of neural stem cell self-renewal.
Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV.
GeneRIF
Tang et al., Chongqing, China. In Antiviral Res, 2012
Gene silencing of hepatitis B virus X protein by RNA interference significantly restored the expression of Drosha.
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.
GeneRIF
Diederichs et al., Heidelberg, Germany. In Neoplasia, 2012
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells
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