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Drosha, ribonuclease type III

Ribonuclease III, Drosha
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Dicer, miR, CAN, Gy-1, prolactin receptor
Papers on Ribonuclease III
Expression of DROSHA in the Uterus of Mice in Early Pregnancy and Its Potential Significance During Embryo Implantation.
Review
New
Liu et al., Chongqing, China. In Reprod Sci, Feb 2016
DROSHA is the microRNA-processing enzyme and is required for the maturation of microRNAs.
Structure of Human DROSHA.
New
Impact
Woo et al., Seoul, South Korea. In Cell, Feb 2016
MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA.
Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets.
New
Weyrich et al., Salt Lake City, United States. In Blood, Feb 2016
Combined Pf4-cre mediated deletion of Drosha and Dicer1 did not significantly exacerbate phenotypes observed in single Dicer1 knockout mice.
MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
New
Impact
Wang et al., Durham, United States. In Cancer Cell, Feb 2016
Interestingly, biogenesis of miR-215 and several miRNAs is accelerated post-transcriptionally by hypoxia-inducible factors (HIFs) through HIF-Drosha interaction.
Characterization of ribonuclease III from Brucella.
New
Liu et al., Wuhan, China. In Gene, Feb 2016
UNASSIGNED: Bacterial ribonuclease III (RNase III) is a highly conserved endonuclease, which plays pivotal roles in RNA maturation and decay pathways by cleaving double-stranded structure of RNAs.
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.
New
Sood et al., Houston, United States. In Oncogene, Feb 2016
Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer and resulting in increased tumor growth and metastasis.
Design of Effective Primary MicroRNA Mimics With Different Basal Stem Conformations.
New
Weinberg et al., Johannesburg, South Africa. In Mol Ther Nucleic Acids, Dec 2015
Cleavage of the pri-miRNA to a precursor miRNA (pre-miRNA) by Drosha-DGCR8 typically occurs adjacent to a basal stem of ~11 bp.
Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.
New
Impact
Chong et al., Australia. In Nat Immunol, Nov 2015
To investigate if the microRNA (miRNA) pathway is required for dendritic cell (DC) development, we assessed the effect of ablating Drosha and Dicer, the two enzymes central to miRNA biogenesis.
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
New
Impact
Anastasiadis et al., Jacksonville, United States. In Nat Cell Biol, Sep 2015
Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at the apical zonula adherens (ZA), defined by the p120 partner PLEKHA7 and a non-nuclear subset of the core microprocessor components DROSHA and DGCR8, and one growth promoting at basolateral areas of cell-cell contact containing tyrosine-phosphorylated p120 and active Src.
Swiss army knives: non-canonical functions of nuclear Drosha and Dicer.
Review
New
Impact
Gullerova et al., Oxford, United Kingdom. In Nat Rev Mol Cell Biol, Jul 2015
The RNase III enzymes Drosha and Dicer are essential for the production of small non-coding RNAs (ncRNAs).
Functional Anatomy of the Human Microprocessor.
New
Impact
Woo et al., Seoul, South Korea. In Cell, Jul 2015
MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of functional miRNAs.
Signaling-mediated regulation of MicroRNA processing.
Review
New
Hung et al., Houston, United States. In Cancer Res, Apr 2015
Canonical miRNA biogenesis consists of a two-step processing, from primary transcripts (pri-miRNA) to precursor miRNAs (pre-miRNA) mediated by Drosha in the nucleus and from pre-miRNAs to mature miRNAs mediated by Dicer in the cytoplasm.
Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis.
Review
Zettl et al., Rostock, Germany. In Mutat Res Rev Mutat Res, 2015
This SNP is suspected to affect the recognition of the primary microRNA hairpin by Drosha and its cofactor DGCR8.
Benefits of Metformin Use for Cholangiocarcinoma.
Kaewpitoon et al., Nakhon Ratchasima, Thailand. In Asian Pac J Cancer Prev, 2014
Furthermore, metformin inhibited CCA tumor growth via the regulation of Drosha-mediated expression of multiple carcinogenic miRNAs.
TRAIL mediated signaling in pancreatic cancer.
Review
Farooqi et al., Santa Maria, Brazil. In Asian Pac J Cancer Prev, 2013
It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7.
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.
GeneRIF
Cáceres et al., Edinburgh, United Kingdom. In Nat Struct Mol Biol, 2012
DGCR8-mediated cleavage of snoRNAs was independent of Drosha, suggesting the involvement of DGCR8 in cellular complexes with other endonucleases. Binding of DGCR8 to cassette exons is a new mechanism for regulation of alternatively spliced isoforms.
The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis.
GeneRIF
Yan et al., Reno, United States. In J Biol Chem, 2012
DROSHA is essential mainly for the canonical miRNA production, and DROSHA-mediated miRNA production is essential for normal spermatogenesis and male fertility.
Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.
GeneRIF
Taylor et al., Freiburg, Germany. In Nat Neurosci, 2012
Drosha is required for maintenance of neural stem cell self-renewal.
Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV.
GeneRIF
Tang et al., Chongqing, China. In Antiviral Res, 2012
Gene silencing of hepatitis B virus X protein by RNA interference significantly restored the expression of Drosha.
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.
GeneRIF
Diederichs et al., Heidelberg, Germany. In Neoplasia, 2012
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells
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