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The ribokinase encoded by this gene belongs to the pfkB family of carbohydrate kinases. It phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, Phosphofructokinase-1, HAD, RBS
Papers on ribokinase
The structural and functional characterization of mammalian ADP-dependent glucokinase.
Sutherland-Smith et al., New Zealand. In J Biol Chem, Dec 2015
We have determined structures of the eukaryotic ADPGK revealing a ribokinase-like tertiary fold similar to archaeal orthologues but with significant differences in some secondary structural elements.
Crystal Structure and Product Analysis of an Archaeal myo-Inositol Kinase Reveal Substrate Recognition Mode and 3-OH Phosphorylation.
Miki et al., Kyoto, Japan. In Biochemistry, Jul 2015
Only two myo-inositol kinases have been identified so far, the TK2285 protein and Lpa3 from Zea mays, both of which belong to the ribokinase family.
Role of monovalent and divalent metal cations in human ribokinase catalysis and regulation.
Guixé et al., Santiago, Chile. In Biometals, Apr 2015
Human ribokinase (RK) is a member of the ribokinase family, and is the first enzyme responsible for D-ribose metabolism, since D-ribose must first be converted into D-ribose-5-phosphate to be further metabolized and incorporated into ATP or other high energy phosphorylated compounds.
Comparative genomics and proteomics of 13 Porphyromonas gingivalis strains.
Olsen et al., Cambridge, United States. In J Oral Microbiol, 2014
Functions unique to individual genomes include: a tetracycline resistance protein TetQ, DNA metabolism gene YcfH, and DNA repair gene exonuclease SbcC (only in SJD2); very-short-patch mismatch repair endonuclease and a phage packaging terminase similar to Bacteroides phage B124-14 (in W4087); an internalin similar to a Listeria surface virulence protein (W83); a Type I restriction-modification system (F0569); an iron acquisition/heme transport protein (F0566); colicin I receptor and carbamoylputrescine amidase (W50); L-serine dehydratase (TDC60); and spermidine synthase and ribokinase (JCVISC001).
Crystallization and preliminary X-ray analysis of a ribokinase from Vibrio cholerae O395.
Sen et al., Calcutta, India. In Acta Crystallogr Sect F Struct Biol Commun, 2014
To provide further insight into the catalytic mechanism, the rbsK gene from Vibrio cholerae O395 encoding ribokinase was cloned and the protein was overexpressed in Escherichia coli BL21 (DE3) and purified using Ni(2+)-NTA affinity chromatography.
Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver.
Witte et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2014
DFA mimics ribose in vivo and accumulates in cells following phosphorylation by ribokinase and further metabolism by transketolase.
Bioretrosynthetic construction of a didanosine biosynthetic pathway.
Bachmann et al., Nashville, United States. In Nat Chem Biol, 2014
A subsequent retrograde pathway extension, via ribokinase engineering, resulted in a didanosine pathway with a 9,500-fold change in nucleoside production selectivity and 50-fold increase in didanosine production.
A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage.
Sieber et al., Garching bei München, Germany. In J Am Chem Soc, 2014
A closer inspection of related enzymes reveals that Cys 110 is conserved and thus serves as a characteristic mechanistic feature for a dual-function ribokinase subfamily herein termed CC-PLKs.
Review of the enzymatic machinery of Halothermothrix orenii with special reference to industrial applications.
Pletschke et al., Grahamstown, South Africa. In Enzyme Microb Technol, 2014
The present review focuses on the purified and characterized enzymes from H. orenii including amylases, β-glucosidase, fructokinase, and ribokinase--along with uncharacterized but industrially important enzymes encoded by the genes identified in the genome such as β-galactosidases, mannosidases, pullulanases, chitinases, α-L-arabinofuranosidases and other glycosyl hydrolases of commercial interest.
The chemoenzymatic synthesis of clofarabine and related 2'-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases.
Mikhailopulo et al., Moscow, Russia. In Beilstein J Org Chem, 2013
The following recombinant E. coli enzymes catalyze the sequential conversion of 2-deoxy-2-fluoro-D-arabinose into the phosphate 12a: ribokinase (2-deoxy-2-fluoro-D-arabinofuranose-5-phosphate), phosphopentomutase (PPN; no 1,6-diphosphates of D-hexoses as co-factors required) (12a), and finally PNP.
NAD(P)H-hydrate dehydratase- a metabolic repair enzyme and its role in Bacillus subtilis stress adaptation.
Licha et al., Praha, Czech Republic. In Plos One, 2013
Previously, we characterized the Bacillus subtilis168 osmosensitive mutant, defective in the yxkO gene (encoding a putative ribokinase), which was recently assigned in vitro as an ADP/ATP-dependent NAD(P)H-hydrate dehydratase and was demonstrated to belong to the SigB operon.
A ribokinase family conserved monovalent cation binding site enhances the MgATP-induced inhibition in E. coli phosphofructokinase-2.
Babul et al., Santiago, Chile. In Biophys J, 2013
Phosphofructokinase-2 (Pfk-2) from Escherichia coli is homologous to ribokinase, but unlike other ribokinase family members, presents an additional site for the nucleotide that negatively regulates its enzymatic activity.
Crystal structure, SAXS and kinetic mechanism of hyperthermophilic ADP-dependent glucokinase from Thermococcus litoralis reveal a conserved mechanism for catalysis.
Guixé et al., Santiago, Chile. In Plos One, 2012
ADP-dependent glucokinases represent a unique family of kinases that belong to the ribokinase superfamily, being present mainly in hyperthermophilic archaea.
Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei.
Barrett et al., Glasgow, United Kingdom. In Plos Comput Biol, 2012
One example of the first type of solution would be the presence of a glycosomal ribokinase to regenerate ATP from ribose 5-phosphate and ADP.
The ADP-dependent sugar kinase family: kinetic and evolutionary aspects.
Merino et al., Santiago, Chile. In Iubmb Life, 2009
Although initially they were believed to represent a new protein family, they can be classified as members of the ribokinase superfamily, which also include several ATP-dependent kinases.
Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase.
Gupta et al., Hamilton, Canada. In Febs Lett, 2007
Identification and characterization of human ribokinase.
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