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Ras homolog gene family, member U

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: Rhodopsin, Cdc42, RhoA, ACID, Rac1
Papers on RHOU
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion.
Wells et al., London, United Kingdom. In J Cell Biol, Dec 2015
Rather, reduced expression of PAK4 leads to a concomitant loss of RhoU expression.
The Rho GTPase Family Genes in Bivalvia Genomes: Sequence, Evolution and Expression Analysis.
Bao et al., Qingdao, China. In Plos One, 2014
RESULTS: In this study, we systematically identified and characterized a total set (Rho, Rac, Mig, Cdc42, Tc10, Rnd, RhoU, RhoBTB and Miro) of thirty Rho GTPase genes in three bivalve species, including nine in the Yesso scallop Patinopecten yessoensis, nine in the Zhikong scallop Chlamys farreri, and twelve in the Pacific oyster Crassostrea gigas.
Associations between single nucleotide polymorphisms and carcass traits in Nellore cattle using high-density panels.
Albuquerque et al., Jaboticabal, Brazil. In Genet Mol Res, 2014
For HCW, associations with SNPs were found on chromosomes 13, 14, and 28, in addition to genome regions that were directly related to this trait, such as the EFCAB8 and VSTM2L genes, and to bone development (RHOU).
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity.
Reiner et al., Houston, United States. In Plos One, 2014
Expression of the human Rho family small GTPase Wrch/RhoU is regulated by Wnt signaling, and Wrch and its paralog Chp/RhoV are both implicated in oncogenic transformation and regulation of cytoskeletal dynamics.
Inhibition of osteoclast bone resorption activity through osteoprotegerin-induced damage of the sealing zone.
Liu et al., Yangzhou, China. In Int J Mol Med, 2014
Treatment with OPG resulted in a significant decrease in the expression of Arhgef8/Net1 and DOCK5 Rho guanine nucleotide exchange factors (RhoGEFs), 10 of 18 RhoGTPases (RhoA, RhoB, cdc42v1, cdc42v2, RhoU/Wrch1, RhoF/Rif, Rac2, RhoG, Rnd1 and RhoBTB1), ROCK1 and ROCK2.
New roles of filopodia and podosomes in the differentiation and fusion process of osteoclasts.
Liu et al., Yangzhou, China. In Genet Mol Res, 2013
In addition, cdc42v1, RhoU, and RhoF regulate the formation of 3 types of filopodia during various stages of differentiation, while Rac1, Rac2, and filament A may be associated with cell selectivity during the fusion process.
Wnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation.
Tse et al., Jinan, China. In Bmc Cancer, 2013
Several molecules in the non-canonical Wnt/Ca2+ pathway were detected in bone marrow samples from AML patients, and the expression of FZD4, FZD5, Wnt5a and RHOU were significantly reduced in newly diagnosed AML samples compared with normal controls.
MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.
Schaeren-Wiemers et al., Basel, Switzerland. In Asn Neuro, 2013
A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics.
Exploratory investigation of genetic associations with basal cell carcinoma risk: genome-wide association study in Jeju Island, Korea.
Lee et al., Cheju, South Korea. In Asian Pac J Cancer Prev, 2013
Consistent with previous GWAS and replication studies in Caucasian populations, PADI6, RHOU and SLC45A2 were identified as having null associations with BCC (P > 0.05), likely due to the smaller sample size.
Functional networks of nucleocytoplasmic transport-related genes differentiate ischemic and dilated cardiomyopathies. A new therapeutic opportunity.
Rivera et al., Valencia, Spain. In Plos One, 2013
Furthermore, the two pathologies shared 6 altered genes: XPO1, ARL4, NFKB2, FHL3, RANBP2, and RHOU showing an identical trend in expression in both ICM and DCM.
Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm.
Tam et al., Westmead, Australia. In Development, 2011
Rhou activity maintains the epithelial architecture of the endoderm progenitors, and its downregulation accompanies the transition of the columnar epithelium in the embryonic foregut to a multilayered cell sheet during organ formation.
GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.
Billadeau et al., In Mol Biol Cell, 2011
data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
Aspenström et al., Stockholm, Sweden. In Biochem Biophys Res Commun, 2011
A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor.
Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.
Cox et al., Chapel Hill, United States. In Mol Cell Biol, 2010
Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src.
The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration.
Blangy et al., Montpellier, France. In Int J Biochem Cell Biol, 2009
As an essential actor of osteoclast differentiation, the atypical RhoGTPase Wrch1/RhoU could be an interesting target for the development of novel antiresorptive drugs.
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2008
The 1p36 locus contains the candidate genes PADI4, PADI6, RCC2 and ARHGEF10L, and the gene nearest to the 1q42 locus is the ras-homolog RHOU.
Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases.
Pacholsky et al., Uppsala, Sweden. In Exp Cell Res, 2007
This review article will focus on the critical aspects of the atypical Rho GTPases, RhoH, Wrch-1, Chp and RhoBTB.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.
Ridley, London, United Kingdom. In Trends Cell Biol, 2006
However, recent research indicates that several other members of the Rho family, including Rif, RhoD, TC10 and Wrch1, and also related Rho-of-plants proteins (ROPs) in plants, stimulate actin polymerization and affect plasma membrane protrusion and/or vesicular traffic.
Biochemical analyses of the Wrch atypical Rho family GTPases.
Der et al., Chapel Hill, United States. In Methods Enzymol, 2005
Wrch-1 (Wnt-regulated Cdc42 homolog-1) and the closely related Chp (Cdc42 homologous protein)/Wrch-2 protein comprise a distinct branch of the mammalian Rho GTPase family.
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