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Ras homolog gene family, member U

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011] (from NCBI)
Papers on RHOU
Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm.
Tam et al., Westmead, Australia. In Development, 2011
Rhou activity maintains the epithelial architecture of the endoderm progenitors, and its downregulation accompanies the transition of the columnar epithelium in the embryonic foregut to a multilayered cell sheet during organ formation.
GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.
Billadeau et al., In Mol Biol Cell, 2011
data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
Aspenström et al., Stockholm, Sweden. In Biochem Biophys Res Commun, 2011
A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor.
Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.
Cox et al., Chapel Hill, United States. In Mol Cell Biol, 2010
Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src.
The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration.
Blangy et al., Montpellier, France. In Int J Biochem Cell Biol, 2009
As an essential actor of osteoclast differentiation, the atypical RhoGTPase Wrch1/RhoU could be an interesting target for the development of novel antiresorptive drugs.
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